Pegetron redipen use

how long after the powder is mixed can the pen still be used?

[hrsepwrguy]

2.6 Preparation and Administration
PegIntron REDIPEN
PegIntron REDIPEN consists of a dual-chamber glass cartridge with sterile, lyophilized peginterferon alfa-2b in the active chamber and Sterile
Water for Injection USP in the diluent chamber. The PegIntron in the glass cartridge should appear as a white to off-white tablet-shaped solid that is
whole or in pieces, or powder.
To reconstitute the lyophilized peginterferon alfa-2b in the REDIPEN:
• Hold the REDIPEN upright (dose button down) and press the 2 halves of the pen together until there is an audible click.
• Gently invert the pen to mix the solution. DO NOT SHAKE. The reconstituted solution has a concentration of either 50 mcg per 0.5 mL,
80 mcg per 0.5 mL, 120 mcg per 0.5 mL, or 150 mcg per 0.5 mL for a single subcutaneous injection.
• Visually inspect the solution for particulate matter and discoloration prior to administration. The reconstituted solution should be clear and
colorless. Do not use the solution if it is discolored or not clear, or if particulates are present.
Keeping the pen upright, attach the supplied needle and select the appropriate PegIntron dose by pulling back on the dosing button until the dark
bands are visible and turning the button until the dark band is aligned with the correct dose. The prepared PegIntron solution is to be injected
subcutaneously.
The PegIntron REDIPEN is a single-use pen and does not contain a preservative. The reconstituted solution should be used immediately and
cannot be stored for more than 24 hours at 2°-8°C [see How Supplied/Storage and Handling (16)]. DO NOT REUSE THE REDIPEN. The sterility of any
remaining product can no longer be guaranteed. DISCARD THE UNUSED PORTION. Pooling of unused portions of some medications has been linked
to bacterial contamination and morbidity.


http://www.spfiles.com/pipeg-intron.pdf