Pharmacokinetics of Ribavirin - absorption factor with high-fat meals, etc.

Came across this article
Came across this article that highlights how ribavirin is absorbed into the body - we talk about taking our riba with a high-fat meal, I was interested to note the actual findings on it and wanted to share this. This article covers other things but this was of particular note to me.

http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1804105

"A complex absorption function was developed to prevent any potential misspecification of the absorption process affecting estimation of the distribution and elimination parameters [15]. A high-fat meal increased relative bioavailability by a factor of 1.46, consistent with the value obtained from a previous noncompartmental analysis (Roche, data on file). Other than a different Ka value for the standard meal, none of the remaining parameters associated with absorption was found to differ from those in the fasting state, suggesting that a standard meal has little or no effect on ribavirin absorption. The variability in relative bioavailability was similar between and within individuals."