Pharmasset Announces Final SVR Data from PROTON trial

http://hcvadvocate.blogspot.com/

"-- 24 out of 24 subjects with HCV genotype 2 or 3 achieved an SVR after 12 weeks of treatment with PSI-7977 400mg QD and pegylated interferon and ribavirin"

"Pharmasset, Inc. (Nasdaq: VRUS) announced today the final sustained virologic response (SVR) results from its phase 2b PROTON study with PSI-7977 dosed once daily in combination with peginterferon alfa 2a and ribavirin (Peg-IFN/RBV) in subjects with hepatitis C virus (HCV) genotype 2 or 3 who have not been treated previously. Twenty four out of twenty four subjects (100%) who completed treatment achieved an SVR, defined as HCV RNA below the limit of detection (<15 IU/ml) 24 weeks after the completion of treatment. No subject exhibited breakthrough on treatment or relapse after treatment."

[Mari5116]

Thanks for the post, awesome.  Treatment seems to be getting better all the time. I'm to begin an all oral trial in the fall which includes PSI-7977.  I hope is does as well for GT1.

[spectda]

Great information. Glad to see the geno 2,3s getting some attention. Hopefully they will be studying the relapsers and non-responders soon.

[onewonders]

Where is the clinical all oral trial that you are participating in being conducted?  Is there a contact person?  Even if it turns out that I can't participate due to distance, I would love to talk to a contact person who can connect me with a clinical trial near me.  Thanks.

BTW, what is your genotype and what other drug(s) are being used in the trial?  Thanks a million.  And best of luck.  I hope with all my heart that you are cured very quickly, with no relapse and with no or minimal side effects.  Such a cure is a dream come true for all of us.  Thanks for blazing the  trail.

[hrsepwrguy]

here is the web page on that clincal trial, it will show you all study locations and contact info

http://clinicaltrials.gov/ct2/show/NCT01329978?term=hepatitis+c+AND+colorado&recr=Open&rank=25


hope that helps
Keith