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Phosphatase level

by jamesz, Sep 13, 2007 11:30PM
Am 69 now. Up to 8 months ago felt & looked like 45. No problems. Then got all the exact symptoms of RA (Rheumatoid Arthritis). Horrible. Medium smoker 40 yrs. Don't inhale much.
Drink coffee all day 30-40 yrs - but all this just nerves and coffee v diluted at 1 tsp per liter.

Recently went for blood test. My Alkaline Phosphatase level is v. high (750). All other indicators (about 65) are ok except low iron and blood platelette count and no immunity to any type of Hepatitis (living in Malaysia, mostly, 40 yrs, where Hepatitis v common.  RA factor negative. All organs ok. Never any serious diseases in all my life.

Consulting blood test Dr. not sure. Says hi level Phosphatase could be due to bone problem,
possible metastases developing at Prostrate, Kidney or Liver. Says I must see specialist which
v expensive.

Any prognosis / comments on my condition?

Jamesz
Member Comments (1)

by CockSparrow, Sep 14, 2007 07:27AM
The following links may help you understand the causes of high ALP.

http://www.labtestsonline.org/understanding/analytes/alp/test.html
http://www.labcorp.com/datasets/labcorp/html/chapter/mono/pr014700.htm

From the Labcorp link. There are many many causes, some of which arent nice.
Causes of high alkaline phosphatase include bone growth, healing fracture, acromegaly, osteogenic sarcoma, liver or bone metastases, leukemia, myelofibrosis, and rarely myeloma.
Alkaline phosphatase is used as a tumor marker.

Hypervitaminosis D may cause elevations in alkaline phosphatase.

In Paget disease of bone there is often isolated elevation of serum alkaline phosphatase. Some of the highest levels of serum ALP are seen in Paget disease.

Cirrhosis, especially in primary biliary cirrhosis, in which fivefold or more increases are seen.

Used alone, alkaline phosphatase may be misleading, so dont read too much into it.
Your Dr is right, you probably do need to see a specialist.

All the Best
CS
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