Hepatitis C Community
Qualitative detection limit for Labcorp test 550400
About This Community:

This forum is for questions about medical issues and research aspects of Hepatitis C such as, questions about being newly diagnosed, questions about current treatments, information and participation in discussions about research studies and clinical trials related to Hepatitis. If you would like to communicate with other people who have been touched by Hepatitis, please visit our new Hepatitis Social/Living with Hepatitis forum

Font Size:
A
A
A
Background:
Blank
Blank
Blank
Blank Blank

Qualitative detection limit for Labcorp test 550400

Hello,

Does anybody here know what the lower detection limit is for labcorp qualitative test #550400 is?
Thanks!
Pete
10 Comments Post a Comment
Blank
Avatar f tn
I would call labcorp and ask them, they are pretty good in customer service. Or ask the lab technician. this post http://www.medhelp.org/posts/Hepatitis-C/1-year-post-test/show/1161397  might assist a bit.  If you get  a negative, that is all you need to know> GL!
Blank
Avatar m tn
OK thanks. I emailed them and asked. I was hoping maybe someone on here has had that test done before and knew the detection limits.
Blank
Avatar m tn
Well I heard back from the technical consultant and this is their reply. Maybe this will be helpful to others for future reference

"Lower detection limit for the HCV PCR qual is 50 copies"
Blank
1669790 tn?1333666195
Your information agrees with the following:

Qualitative HCV RNA tests include the qualitative RT-PCR, of which the Amplicor™ HCV 2.0 (Roche, USA) is an FDA- and CE-approved RT-PCR system for qualitative HCV RNA testing that allows detection of HCV RNA concentrations down to 50 IU/ml of all HCV genotypes (Nolte 2001).

http://www.flyingpublisher.com/0011_03.php
Blank
Avatar m tn
Thanks flycyclist. Interesting that they would offer that test when their regular RT-PCR Quantitative test has an ability to detect HCV genotype 1 down to 7.1 IU/mL and for genotype 2 it is 15.3 IU/mL.

Reason I'm curious is because it appears that I have cleared the virus sponateously. I was diagnosed 4.5 years ago and had multiple antibody tests, and a viral load test as recently as 2.5 yrs ago to confirm it. went to doc to get genotype testing and the test couldn't be done because it has a cut-off of 600 IU/mL. Then got the taqman RT-PCR quantitative and it said "not detected".  Went back in and am waiting results on the above referenced qualitative.  If this comes back negative I'm going to ask doc to do the NGI quantasure with a sensitivity down to 2 IU/mL. At that point I guess I am free and clear right?  Doctor has never seen this before so he doesn't know what to do.
Blank
1669790 tn?1333666195
It could be the difference in cost between the qualitative and quantitative tests.
I understand your desire to use the most sensitive PCR available just to make sure.  Labcorp's RT-PCR Quantitative limit of detection is 7.1 IU/mL for HCV genotype 1, and the quantifiable range of the assay is 25 IU/mL.  I believe Quest's limit of detection is the same, but their quantifiable range is 43 IU/ml.  

Is it worth the cost and additional waiting period for the NGI quatasure test?  If you did have HCV, I'd suspect the viral load to be higher than 7.1 IU/mL.  But again, I understand your approach.  
Blank
Avatar m tn
Well for me the cost isn't a consideration. I get free labs through them as an employee. I just want to be as absolutely sure as possible. I have read the study about patients with very low viremia, so yes I am a little(a lot) paranoid, and just want to be absolutely sure and close the chapter on this once and for all.  Frankly I'm still in a state of shock over the fact that from all appearances I don't have it anymore.
Blank
Avatar m tn
Just an update. It seems like the lab performed the wrong test. From what I could tell over phone, an antibody follow-up test was ordered. Of course I tested positive, but the s/co was 6.5. Now I've gone back and had the NGI quantasure test done. Am waiting results on that. Will post when I get labs back.
Blank
Avatar m tn
Just an update. Got my ngi quantasure test back and i'm undetectable. Looks like I spontaneously cleared the HCV. Thank God what a miracle. I'm in a state of shock.
Blank
Avatar f tn
Good info and congrats!
Blank
Post a Comment
To
Recent Activity
Avatar universal
Blank
PaintingLife joined this community
Welcome them!
23 hrs ago
707563 tn?1455827280
Blank
317787 tn?1463415842
Blank
Dee1956 commented on Belle313's status
May 24
Blank
Weight Tracker
Track your weight over time
Start Tracking Now
Top Hepatitis Answerers
Avatar m tn
Blank
can-do-man
IN
683231 tn?1438659664
Blank
flyinlynn
Auburn, WA
446474 tn?1446351282
Blank
HectorSF
San Francisco, CA
163305 tn?1333672171
Blank
orphanedhawk
Rural Mural, CA
1815939 tn?1377995399
Blank
pooh55811
317787 tn?1463415842
Blank
Dee1956
DC
Hepatitis C Community Resources
RSS Expert Activity
233488 tn?1310696703
Blank
Marathon Running Done Over Many Yea...
05/15 by John C Hagan III, MD, FACS, FAAOBlank
233488 tn?1310696703
Blank
New Article on Multifocal IOL vs &q...
05/15 by John C Hagan III, MD, FACS, FAAOBlank
748543 tn?1463449675
Blank
TMJ/TMJ The Connection Between Teet...
01/15 by Hamidreza Nassery , DMD, FICOI, FAGD, FICCMOBlank
Top Hepatitis Answerers
Avatar m tn
Blank
can-do-man
IN
683231 tn?1438659664
Blank
flyinlynn
Auburn, WA
446474 tn?1446351282
Blank
HectorSF
San Francisco, CA
163305 tn?1333672171
Blank
orphanedhawk
Rural Mural, CA
1815939 tn?1377995399
Blank
pooh55811
317787 tn?1463415842
Blank
Dee1956
DC