Question about IL28B test

[EyesofBlue55]

Seeing that I have the CC alleye,what is the probability that someone else in the family has the cc also???They have diagnosed my brother with hep c also( probability of contaminated gamma globulin shot in the early 1980's).He  has not had the IL28B test.Actually doesnt want to know.Was just wondering if genetic makkers would be the same since were brother and sister??? cindy

[Aaron57]

Telaprevir/ Inciveck response's relative to IL28B allele

According to this data, it shows apx. 33% of folks have the lucky CC allele .. my mistake above .. the data for the Advance trial are here .. PR (Peg/Riba) compared to Tela responses by allele's ...

TT allele with Tela/Inciveck achieved the avg. apx 75% success ... with PR Tx .. 23%  ..

Imo IL28B is a non issue with Inciveck Tx ... if with PR Tx, a different story ...

http://hepatitiscnewdrugs.blogspot.com/2011/05/telaprevir-based-hcv-treatment-benefits.html

[EyesofBlue55]

Thx all.My brother will be txing with triple therapy soon.We had just gotten into the conversation about the il28 gene.Just kinda wondering what the odds were that he was a CC also.He said it didnt matter what he had-he was gonna kick some viral *** !!! We would be txing together had it not been for my bumb arm that I have to fix first.Tx slows the healing process thats why I cant do it together Im guessing.First things first...cindy

[Aaron57]

It does sure ... but only to a certain extent Will , If her brother/anyone checks and has the CC allele , Inf/Riba only would seem in order, 15% of people have this lucky gene  ..

The IL28B tests are available now, but he doesn't want to know ..

What I should have wrote is that IL28B should not be much of a consideration if a patient is considering the triple therapy as the success rates far exceed those of Inf/Riba for all allele's .. especially for CT & TT allele's ...  

[willbb]

The IL28b allele issue does not have an impact on treatment success if the patient is using the new triple therapy - PI's ..

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Is there not data that shows that  whatever the IL28B  alelle.... it does have an impact with Inciveck?
Will

[Aaron57]

Is your brother considering Inf/Riba SOC Tx only ... or the new triple therapy with a PI ?

The IL28b allele issue does not have an impact on treatment success if the patient is using the new triple therapy - PI's ..

The same goes for IR .. insulin resistance ... which lowers the chance of success in G1 by 20% in SOC treatment ... not so for the PI's ... they both are non issues for the PI's ...

There is quite a bit of data published on this subject in EASL , Clinical Care Options , PubMed websites, and, many others ...  the data is taken from all the clinical trail results for the PI's ..

If considering Inf/Riba only ... both IL28b and IR should be tested ... before starting Tx, along with all the other pre treatment testing required in order to make an informed decision .

Guessing is not a real good way to choose Tx options, we now have these tests available ! ! .. imo

[desrt]

If both parents are CT, you could have siblings who are CC and TT.

[EyesofBlue55]

Correction-he will be either a CC or CT I believe.with the 50% if one parent has the CT...and the other is CC

[EyesofBlue55]

According to this you get one copy of the genome-one from each parent.So I believe my brother will be the same if we have the same parents.Correst me if wrong cindy
    
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The site is close to the gene for a special kind of interferon, known as interferon-lambda-3, and may help control the gene’s activity. Some people have the DNA unit T at this site, and others have C. Since a person inherits two copies of the genome, one from each parent, individuals may have T’s on both copies, C’s on both, or one T and one C.



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What Are Alleles?

Alleles are corresponding pairs of genes located at specific positions in the chromosomes. Together, alleles determine the genotype of their host organism.
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For example, the alleles for eye color are found on chromosomes 15 and 19, and depending on which alleles someone has, he or she may have blue, brown, green, gray, or hazel eyes, and sometimes a mixture of these traits is present.
Source

What Are "C" and "T" Alleles ?

As mentioned above a person inherits two copies of each gene; one from each parent to make up each allele. The IL28B rs12979860 SNP has two alleles or variations which are regonized as "C" and "T".
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Then What Is C/C or "CC" ?
In Hepatitis C patients who have the C/C pattern simply means that they have two copies of the "C" allele.
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Then What Is T/T or "TT" ?
The same is true in Hepatitis C Patients who have the T/T pattern or two "T" alleles .
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What Does This Mean To The Hepatitis C Patient?
Hepatitis C Patients With The C/C pattern or two "C" alleles have the best response to HCV therapy.
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As for the T/T pattern or two "T" alleles they have the least response to therapy.
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What If A Person Has The C/T pattern?
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The C/T pattern would mean the person has one copy of each allele. These people would fall somewhere in between.
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Summarize All Of This Please
TT - Poorest response to Hepatitis C treatment
CC - Best response to Hepatitis C treatment.
CT- Somewhere in between TT and CC alleles.
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[SusieS2010]

i'm just guessing here but don't you get one allele from your mother and one from you father? so siblings should test the same on the IL28b test.
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Only if both parents are pure for cc will the siblings be the same. If dad is cc and mom ct, the offspring have a 50% chance of being a cc or a ct. That is, if it is inherited as a simple dominant recessive.

[EyesofBlue55]

IDK and cant find any info on it cindy

[coeric]

i'm just guessing here but don't you get one allele from your mother and one from you father? so siblings should test the same on the IL28b test.