Question about olysio/sovaldi

[saltavar]

I was still positive after tx with olysio and sovaldi at 8 weeks so they stopped the treatment. It came close at week 2.
Is there a risk that I may now be resistant to ant future treatments? This is my first go at it. 50 years with hcv. They believe I have cirrhosis but it hasn't been confirmed by biopsy. Ultr showed "suggestive" of cirrhosis. In 2010 the biopsy sample was small and they called it still stage 1, confirming a 1999 biopsy at stage 1. Geno 1a. I feel like a lab rat. Maybe I'll go back to my supplement protocol and wait a while before tx again. I don't know right now. I just found out this failure yesterday. Got a lot on my plate right now.

What are tags and how do they work?


Bob

[saltavar]

They did the q80 test before my tx and it was sensitive to it. So that wasn't the reason mine failed.

[bluemetal]

Failed tx on Sov/Olys is not a bar to future tx on Sov/Led. And even if it becomes a controversial issue amongst scientists and hepatologists, do we have any choice? Its to my understanding that the Sov/Led combo coming out in 1-2 months is designed specifically for gt1a cirrhotic and non cirrhotic tx naieve AND tx experianced. Tx experianced would, I presume, include those who failed the Sov/Olys horror train ride. Olysio and Ledisprvir, albeit both protease inhibitors have one distinct difference in that Ledisprvir is effective against the Q80K mutant gene which is present in approx half of all gt1a's. This, I bleive is why so many sides and failures. Add age, other med conditions , etc, and zap--you have a drug actually doing more harm than good. Again, I point out that although I strongly belive the Sov/Led will be effective for most gt1a's it comes with a price other than thousands of dollars-- tax on the liver. Tx experianced will endure better than tx naieve because thier livers are battle-hardned and will become even more battered. All-in-all it beats a transplant . I base this on a combination of study and experiance.  This is my personal opinion. A doctor or hepatologist should be consulted for a professional assessment because each case is different.

[saltavar]

I will add to my original post  that the test only showed positive or negative at week 8. The week 2 test was very close to negative. why would they shut it down on a positive/ negative test? Maybe it just took longer for me?