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Hepatitis C (Expert Forum)
Relapsed, from Roche R1626/Prodrug
Answered by
Douglas Dieterich, MD - Internal Medicine, Gastroenterology
The Mount Sinai Medical Center
New York - NY
Questions posted in the Hepatitis C Forum are answered by medical professionals from The Mount Sinai Medical Center.
Relapsed, from Roche R1626/Prodrug
by Dee1956, Jan 30, 2009 12:29PM
Hello, I am a 52 year old 140 lb female. I am a Geno Type 1A with Grade 2 Stage 4 . When I started treatment on 2/1/08 my viral load was 12M, within 8 weeks of the triple combo I was undetectable. I took 180iu of peg (reduced to 135 after 4 weeks), 1000 Riba and 1000mg of R1626 (16weeks) I continued to be undetectable until I had to stop treatment due to dangerously low lymphocytes and CD3/CD4 on Nov 26 2008; after having done 43 of 48 weeks. On Jan 2nd the blood work showed I relapsed and my viral load was 4M. I would like to know how long I should wait to retreat. How should I retreat? I wonder if I had been able to take the full dose of the Peg if I would have had a better chance. The Prodrug affected me so badly that they had to reduce the Peg. I have not taken the R1626 since June of 08, it is now Jan 09 and my immune system is still affected
I would appreciate any advice or information you can share. My doctor said that it would be a waste of time to try 48 weeks of SOC since I took that however I really didn't 135iu is not 180 and 43 is not 48. I have been told that because I am stage 4 I will need to treat more aggressively or maybe longer. I am very confused and afraid.
Thank you
Dorene
I would appreciate any advice or information you can share. My doctor said that it would be a waste of time to try 48 weeks of SOC since I took that however I really didn't 135iu is not 180 and 43 is not 48. I have been told that because I am stage 4 I will need to treat more aggressively or maybe longer. I am very confused and afraid.
Thank you
Dorene
Doctor's Answer
by Douglas Dieterich, MD, Feb 02, 2009 06:32AM
, Feb 02, 2009 06:32AMTo: Dee
I would wait as well with this one. This drug has had some bone marrow effects and they seem to last a long time. You may be able to qualify for a protease trial or one of the two proteases when they get approved in 2011. Certainly rushing to treat now would be a mistake. Take some time off and cure your liver, your marrow and your soul. then we can deal with this next year.
DTD
DTD
Study doc not helpful. Thank you so very much!
Dee