Aa
A
A
Close
Avatar universal
SGOT and SGPT
I used to have a high cholesterol and i have been taking Vytorin for the last 22 days and now my cholesterol is back to normal. However my SGOT increases to 56 and SGPT 100. Is Vytorin causes SGOT and SGPT to increase? Also, i have taken Anti hepatitis 2x. Does this have possibility to increase the SGOT and SGPT?
Cancel
3 Answers
3 Answers
Page 1 of 1
766573 tn?1365170066
You might want to discuss this with your doctor. The prescribing info on the Merck site says

It is recommended that liver function tests be performed before the initiation of treatment with Vytorin.
http://www.merck.com/product/usa/pi_circulars/v/vytorin/vytorin_pi.pdf

EMedTV has an article that explains some statins are associated with high liver enzymes. It says increases in liver enzymes occur in 1.7 percent of people taking Vytorin. This increase appears to be more prevalent in people who are taking higher doses.

It goes on to explain other causes of high liver enzymes. The bottom line is the person best to determine this is one who is familiar with your medical history as well as your labs prior to starting the medication.

Here is the link:
http://cholesterol.emedtv.com/vytorin/vytorin-and-liver-problems.html
_____________________________

Do you mean you wonder if testing for hepatitis C antibody would cause your liver enzymes to increase? Drawing the blood? Were your Antibody tests negative (or nonreactive)?
Comment
Cancel
766573 tn?1365170066
Comment
Comment
Submit Comment
1747881 tn?1358189534
Vytorin

Warnings and Precautions

Liver Enzymes

In three placebo-controlled, 12-week trials, the incidence of consecutive elevations (≥3 X ULN) in serum transaminases was 1.7% overall for patients treated with Vytorin and appeared to be dose-related with an incidence of 2.6% for patients treated with Vytorin 10/80. In controlled long-term (48-week) extensions, which included both newly-treated and previously-treated patients, the incidence of consecutive elevations (≥3 X ULN) in serum transaminases was 1.8% overall and 3.6% for patients treated with Vytorin 10/80. These elevations in transaminases were generally asymptomatic, not associated with cholestasis, and returned to baseline after discontinuation of therapy or with continued treatment.

​In SHARP, 9270 patients with chronic kidney disease were allocated to receive Vytorin 10/20 mg daily (n=4650), or placebo (n=4620). During a median follow-up period of 4.9 years, the incidence of consecutive elevations of transaminases (>3 × ULN) was 0.7% for Vytorin and 0.6% for placebo.

It is recommended that liver function tests be performed before the initiation of treatment with Vytorin, and thereafter when clinically indicated. There have been rare postmarketing reports of fatal and non-fatal hepatic failure in patients taking statins, including simvastatin. If serious liver injury with clinical symptoms and/or hyperbilirubinemia or jaundice occurs during treatment with Vytorin, promptly interrupt therapy. If an alternate etiology is not found do not restart Vytorin. Note that ALT may emanate from muscle, therefore ALT rising with CK may indicate myopathy [see Warnings and Precautions (5.1)].

Vytorin should be used with caution in patients who consume substantial quantities of alcohol and/or have a past history of liver disease. Active liver diseases or unexplained persistent transaminase elevations are contraindications to the use of Vytorin.

http://www.drugs.com/pro/vytorin.html#i4i_section_id_3a5570a3-3e19-49a8-be68-29643102eaa6
Comment
Cancel
1747881 tn?1358189534
Comment
Comment
Submit Comment
Avatar universal
Thank you for your explaination. Now i have stopped taking vytorin beccause my cholestrol has lowered to 135. What i meant was, i have take 2x out of 3x anti hepatitis jab. However when i tested, the result was negative which is non-reactive. Why is that so? Do i need to have taken 3x before it is reactive?
Comment
Cancel
Avatar universal
Comment
Comment
Submit Comment
Your Answer
Avatar universal
Answer
Know how to answer? Tap here to leave your answer...
Answer
Submit Answer
A
A
Recent Activity
317787 tn?1460223707
Blank
Dee1956 commented on VICourageous's status
6 hrs ago
Avatar universal
Blank
Vendetta2016 commented on Is It the Common Cold...
16 hrs ago
1415174 tn?1453246703
Blank
mkh9 commented on Londres70's status
Apr 30
Blank
Weight Tracker
Track your weight over time
Start Tracking Now
Top Hepatitis Answerers
1815939 tn?1377995399
Blank
pooh55811
Avatar m tn
Blank
can-do-man
IN
317787 tn?1460223707
Blank
Dee1956
DC
683231 tn?1438659664
Blank
flyinlynn
Auburn, WA
163305 tn?1333672171
Blank
orphanedhawk
Rural Mural, CA
446474 tn?1446351282
Blank
HectorSF
San Francisco, CA
Hepatitis C Community Resources
Top Hepatitis Answerers
1815939 tn?1377995399
Blank
pooh55811
Avatar m tn
Blank
can-do-man
IN
317787 tn?1460223707
Blank
Dee1956
DC
683231 tn?1438659664
Blank
flyinlynn
Auburn, WA
163305 tn?1333672171
Blank
orphanedhawk
Rural Mural, CA
446474 tn?1446351282
Blank
HectorSF
San Francisco, CA