SOC & VL at week 4

[AnotherJourney]

Just curious...would like to hear from those who have done SOC of Peg & Riba (not a CT) and what was your beginning VL and your 4 week VL

[Marcia2202]

Base line 1,300,000
4 weeks   80

[jdwithhcv]

Baseline was 6,000,000
4 week was UND

[justme53]

Baseline 848,000

4 week     38,600

[AnotherJourney]

Opps and another important thing... what is your Genotype?

[meakea]

Genotype 1b

Baseline VL:   30,100

4 wk VL:  UND

[kitkat14]

baseline 9,450,000

4 weeks   24

geno 1B

[justme53]

Genotype 1a  cirrhosis

[charm27]

Gentype  1A
My VL jumped from 8 million to 75 million b4 tx.

4 week PCR= 330
7 Week- UND.

Stage 2 Grade 2- mild activity

[Tippyclubb]

Of those who where not UND at week 4 when did you become UND?

[justme53]

Still waiting......I won't get retested until 12 weeks. Now at week 8. March 23rd is the red letter date.

[CMcH]

starting VL 345.000 4 week und <60 per sensitivity of test. 12 week UND <5.
I am now at 40/48 1a grade 1/1.
I did not get tested before 4 weeks and I think that is fairly standard.
It would have been nice every 2 but UND at 4 wks upgrades your SVR odds to 90%
I have read about some studies now that show low starting VL and UND at 4 wks have been able to reduce TX to 24 weeks.
It is tempting for me because of all these crummy side effects but I would never forgive myself if I stopped early and was not SVR. I did drop my Riba does at 24 weeks due to anemia problems even with rescue drugs.

[Tippyclubb]

I have read about some studies now that show low starting VL and UND at 4 wks have been able to reduce TX to 24 weeks.

----------------------------------------------------------

I thought being able to quit at week 24 was for those on PI's.  If your UND at week 4 with SOC you can stop at 24?  I never heard of this before.

[kitkat14]

I've also read about stopping treatment after 24 weeks if you reach UND at 4 weeks.  I believe they have even changed the protecol in parts of Europe as a result.

I was at a viral load of 24 at 4 weeks so I am sticking out the 48 weeks, as tempting as 24 weeks shorter treatment sounds.

k

[zazza]

Genotype 1a

Baseline: 120,000 IU/ml (bDNA test)

Week 4: 2900 IU/ml (Taqman test)

Week 12: detectable but not quantifiable <15 IU/ml (Taqman test)

Week 15: UND

Did 72 weeks

SVR

[chuckles333]

genome 2b
base 538,000
4 week UND
@ week 8 now 12 week VL in 4 weeks. will post

[jankar]

1b
starting VL 245,000
4 week <15 Taqman Test
12 week UND Taqman Test
Grade 0 Stage 0
stopped treatment at 27 weeks 8 April 2009
Next PCR  8 October 2009
No riba reduction during treatment
AST and ALT normal from Week 12

[eureka254]

husband's stats:
geno 1, baseline VL 17.2 million
4wk VL  9,310
8wk VL  71
12wk VL detectable <50
13wk VL UND <5

[eureka254]

PS with added Alinia off-label, stage 4 cirrhosis