SVR living liver donor to HCV neg recipient

"Living donor liver transplantation from a donor previously treated with interferon for hepatitis C virus: a case report.
Hidaka M, Takatsuki M, Soyama A, Miyaaki H, Ichikawa T, Nakao K, Kanematsu T, Eguchi S.
Abstract

ABSTRACT:
INTRODUCTION:

Selecting a marginal donor in liver transplantation (LT) remains controversial but is necessary because of the small number of available donors.
CASE PRESENTATION:

A 46-year-old Japanese woman was a candidate to donate her liver to her brother, who had decompensated liver cirrhosis of unknown origin. Eight years before the donation, she had a mild liver dysfunction that was diagnosed as a hepatitis C virus (HCV) infection (serotype 2). She had received anti-viral therapy with interferon -2b three times weekly for 24 weeks and had a sustained viral response (SVR). A biopsy of her liver before the donation showed normal findings without any active hepatitis, and her serum was negative for HCV-RNA. Only 67 patients have undergone LT from a cadaveric donor in Japan. The family in this case decided to have living donor LT. A careful selection for the liver graft donation was made; however, since she was the only candidate, we approved her as a living donor. She was discharged nine days after the liver donation. Her liver function recovered immediately. A computed tomography scan showed sufficient liver regeneration one year later. Her brother also had good liver function after LT and had no HCV infection 48 months after surgery and no de novo malignancy. Neither of the siblings has developed an HCV infection.
CONCLUSIONS:

A patient with SVR status after interferon therapy might be considered a candidate for living donor LT but only if there are no other possibilities of LT for the recipient. A careful follow-up of the donor after donation is needed. The recipient also must have a very close follow-up because it is difficult to predict what might happen to the graft with post-transplant immunosuppression.

http://www.ncbi.nlm.nih.gov/pubmed/21722402

[desrt]

Very cool. I guess we assume she was part of the 10-15% who show no sign of occult after SVR/self-clearance. The bx and serum tests would be the only tests necessary since the triple blood marker tests

http://www.ncbi.nlm.nih.gov/pubmed/20648609

also check for occult in other parts of the body and wouldn't be relevant.

[desrt]

Very cool. I guess we assume she was part of the 10-15% who show no sign of occult after SVR/self-clearance. The bx and serum tests would be the only tests necessary since the triple blood marker tests

http://www.ncbi.nlm.nih.gov/pubmed/20648609

also check for occult in other parts of the body and wouldn't be relevant.

[mikesimon]

Since his sister cleared 8 years previously it's possible that she may have been absolutely clean (no occult/persistent HCV) and, if she was, I'd assume the recipient (her brother) was as well. I am always interested in the occult stuff but as a practical matter I doubt it's a big deal for SVRs.

Mike