Sounds like you're ready for a shot of procrit! (pending hgb ct, of course)
OK, I'm back from the beach. That is the study I'm in. I'm in the arm that gets just Peg and Riba for 12 weeks. I'm waiting on my result to see if I cross over or not. I'll be calling them tomorrow because I've taken a real turn for the worse with the sides. Almost passed out doing yard work, and can hardly get up the steps. And I think I'm depressed as well. Ask away if you have any questions, I've got my paperwork handy by the sick bed!
Ok it's totally up to you when and how you tx but it's more likely that they would give you more of the PI than you need.
fret
i'm in the arm 3 week 3 of this trial. Went from over 6mil vl pre tx to 34 in the first week!!!
bill
thanks everyone pls keep this thread alive, ya i am thinking of participating, but its only phase 2, i might wait for the phase 3... im afraid of under dosing with the PI and maybe the phase 3 trial will resolve that question... as willy said i do not want to worry about potential resistance issues
That sounds like the trial I'm in. I'm at the beach until late Sunday, so I can't confirm by reading my documentation. I don't trust my brain right now to say it is without double (or triple) checking. I've had a rough couple weeks and haven't been very active on the forum. I'm waiting on the result of my 12 week to see what the next step is. Very likely cross-over arm to the study drug, along with Ritonavir (that one I'm sure of). I'll watch this thread and post back with more info when I get back home.
http://clinicaltrials.gov/ct2/show/NCT00797745?term=SCH+900518&rank=1
looks like a good trial.
I would expect it to be better than boceprevir or they wouldn't be advancing it. Looks very promising but I don't think they got off the charts response per last EASL. A few months ago it was 15X stronger than any PI. Now it seems to be 10X stronger than boceprevir. That is still a good thing. To be fair there are many new compounds continually raising the bar. Whatever is "top gun" this week may become second fiddle by fall AASLD. Ten times more potent than boceprevir would be formidible. It will remain to be seen how the tolerability/ toxicology aspects are. It could be both more potent and more toxic. That's what trials are for.....finding out. ; )
Looks good and promising to me. I like the structure of their arms far more than w/Vertex. Standard for vertex is 1 control, 2 or 3 investigational arms. (chances of getting SOC is 1 in 3 or 4)
This trial has one control and 6 investigational arms; 1 chance in 7 of getting placebo (SOC).
Keep i mind that these also are dosing strength arms and therfore one *could* get a less than optimal dose of the new PI. IF you treat with PI's you want to CURE or there could be potential resistance issues.
best,
Willy
There's someone in here that is currently in that trial, although I don’t remember his name. It looks very promising, and they’re also combining it with an HIV protease inhibitor ‘ritonavir’. I think this is the drug Schering-Plough touts as “10 times more powerful than Boceprevir” in their press release. The trial info is available in clinicaltrialsdotcom, I believe. Are you considering participating?
Bill