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Starting clinical trial
I will be taking either:

sofosbuvir and gs 5885 for 12 weeks or

sofosbuvir and gs 5885 and ribavirin for 12 weks  or

sofosbuvir and gs 5885 for 8 weeks

I have no prior tx, am genotype 1a, have had hepc for over 35 years

any ideas of which above would be best...? what is the expectation for SVR

thanks in advance
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1815939 tn?1377995399
Welcome to the forum.

Here is a thread all about the drugs you will be taking. If you read through the entire thread maybe you will get some of the answers to your questions. I will also look for some other information and post it if I can find it. In the meantime, here is the thread. Just click on it and I think you will find a lot of information:

http://www.medhelp.org/posts/Hepatitis-C/Starting-Sofosbuvir-GS-5885/show/1875802
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1815939 tn?1377995399
Here is a link to a report about the drugs you will be taking. The SVR rates are included. Just copy and past it into your browser:

http://seekingalpha.com/news-article/6421611-gilead-reports-interim-data-from-phase-2-lonestar-study
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Your chances are excellent being treatment naive. I  finished up the gilead 12 week study with GS5885 (ledipasvir)/sofosbuvir/riba 8 weeks ago. I finally went UND on this Study trial. This is my 4th attempt with the first 3 Tx attempts (with interferon) being failures. Please take advantage of this opportunity.
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Thanks for encouragement. I have psoriasis and depression hx so interferon tx was never an option for me. I had this for over 37 years.... so im very thankful for this chance.
john
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I have also just started this study - but here in the UK it's 12 or 24 wks w or without Riba. I got the GS5885 for 12 wks with Riba. Happy to compare notes. where are you based and which arm did you get? I too am 1a treatment naive; Hep C 30+ yrs. having a few nausea probs but figuring out what to eat for the best.
good luck
Raina M
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sorry, I meant sofosbuvir and 5885 of course
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I'll find out when i get first dose end of may...

I would like the 12 weeks without riba.....but its a roll of the dice... best of luck to us
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1815939 tn?1377995399
Keep us posted on how things go with your trial. Here's hoping your treatment will be smooth and successful.
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Best of luck with tx.  You have an excellent chance here.  Keep us posted and let us know how you are doing.
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