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Statins and Hep C
After clearing the virus Geno 2b in (09) and having good enzymes levels now ( AST 34, ALT 24 ) my Dr wants to increase my simvastatin from 10 mg per day to 80 mg  since I have ischemic heart disease. I'm concerned about such a high dose of statins effecting my liver and I'm concerned about my heart condition. Anyone have any input for me ?  
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446474 tn?1446351282
I don't exactly understand your concern. You no longer have the hepatitis C virus which was damaging your liver. Did you have advanced liver disease before you cleared the virus and still have extensive damage? What was the stage of your liver disease according to biopsy either before or after your treatment? Or are you concerned about anything that could cause liver damage in general?

From the Mayo Clinic website:
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http://www.mayoclinic.com/health/statins/CL00010

'Potentially serious side effects

    Liver damage. Occasionally, statin use causes an increase in liver enzymes. If the increase is only mild, you can continue to take the drug. Rarely, if the increase is severe, you may need to stop taking it. Certain other cholesterol-lowering drugs, such as gemfibrozil (Lopid) and niacin (Niacor, Niaspan), increase the risk of liver problems even more in people who take statins.

    Although liver problems are rare, your doctor will likely order a liver enzyme test before or shortly after you begin to take a statin. You shouldn't need any additional liver enzyme tests unless you begin to have signs or symptoms of trouble with your liver. Contact your doctor immediately if you have unusual fatigue or weakness, loss of appetite, pain in your upper abdomen, dark-colored urine, or yellowing of your skin or eyes.'
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Since liver damage is rare with statins, you shouldn't have anything to worry about unless you still have extensive damage to your liver caused by the hepatitis C.

Good luck.

Hector



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