Aa
TYLENOL OR ADVIL?
I was looking for the post of which is best tylenol or Advil and could not find it. Can someone that has it send it to me:) Thanks
Thanks to all for the info. I took advil when needed for years and this year i was told by the hepatologist to take Tylenol to avoid kidney complications in the future. I have read several articles in the net and they are all diferent. I never really take pain meds but since I am looking into Harvoni and headaches are a side I want to be ready.
I was told by the transplant team here to take 1- 500 Mg Tylenol no more than 3x a day I also have cirrhosis also but I really don't want to do more damage so I try not to take any at all but if I have to, I take as I was told good luck
Thank you for the information about aspirin. It was very interesting
Fred When I had HCV I was told to take no more than 2,000 mg a day of tylenol.
Last year I ruptured a disc, the pain was unbearable, my hepatologist said that I could take Advil since I no longer had the HCV attacking my liver.
I still keep the dose low and try to do without.
Fred When I had HCV I was told to take no more than 2,000 mg a day of tylenol.
Last year I ruptured a disc, the pain was unbearable, my hepatologist said that I could take Advil since I no longer had the HCV attacking my liver.
I still keep the dose low and try to do without.
My Hep doc told me I could use either Tylenol or Advil....in moderation and below daily recommended amount of course.
http://health.clevelandclinic.org/2013/09/acetaminophen-vs-ibuprofen-which-works-better/
http://health.clevelandclinic.org/2013/09/acetaminophen-vs-ibuprofen-which-works-better/
http://hepatitiscnewdrugs.blogspot.com/2014/11/aasld-aspirin-might-protect-against.html
AASLD - Aspirin Might Protect Against Liver Fibrosis
0
Tuesday, November 11, 2014
Posted by HCV New Drugs
FILE UNDER AASLD 2014, HCV NEWS, LIVER FIBROSIS
Medscape Medical News from: The Liver Meeting 2014: American Association for the Study of Liver Diseases (AASLD)
Good Old Aspirin Might Protect Against Liver Fibrosis
Neil Osterweil
November 10, 2014
BOSTON — Will wonder drugs never cease? Aspirin, already touted for its cardiovascular and anti-inflammatory prowess, seems to be flexing its muscles against liver fibrosis, particularly in people at risk for chronic liver disease, according to new research.
"Clinical equipoise is emerging that may justify prospective randomized trials of aspirin and, potentially, other antiplatelet drugs such as antifibrotic agents," Gordon Jiang, MD, a gastroenterology fellow at the Beth Israel Deaconess Medical Center in Boston, and colleagues state in a scientific poster here at The Liver Meeting 2014.
In a population-based cross-sectional study of more than 14,000 adults, there was "a consistent association between aspirin use and less liver fibrosis," Dr. Jiang and colleagues report.
The team drew on the National Health and Nutrition Examination Survey (NHANES) III to look at the association between aspirin, ibuprofen, and liver fibrosis. Fibrosis was measured with four validated noninvasive indices: Fibrosis-4, the nonalcoholic fatty liver disease fibrosis score, the aspartate aminotransferase/platelet ratio index, and the Forns Index.
To see if the association between aspirin and fibrosis protection is stronger in patients most at risk for fibrosis, they did additional analyses in patients with viral hepatitis, heavy drinkers, and patients with fatty liver disease.
On the four measures, the use of aspirin was consistently associated with lower stages of liver fibrosis. In contrast, there was virtually no link between ibuprofen use and liver fibrosis.
Similarly, in an analysis of patients with and without chronic liver disease (hepatitis B or C infection, more than 5 alcoholic drinks per day, or suspected nonalcoholic steatohepatitis), aspirin but not ibuprofen was consistently associated with lower stages of fibrosis.
For patients with or at risk for liver disease, compared with those without risk factors, there was about a 5-fold increase in the negative coefficient for the interaction between aspirin use and liver fibrosis. This suggests that the protective effect of aspirin is much larger in patients with chronic liver disease, said researcher Yury Popov, MD, PhD, assistant professor of medicine at the Beth Israel Deaconess Medical Center.
The researchers acknowledge that the study was limited by the observational design, and by that fact that the NHANES III data were limited to 1 month of drug use, "whereas the protection against liver fibrosis likely requires long-term use."
They speculate that the antiplatelet activity of aspirin, rather than its anti-inflammatory properties, likely account for its positive effects on fibrosis.
"Our observations support emerging experimental and clinical evidence for a pathologic link between platelet activation and liver fibrosis," they write.
In a separate study, also presented here, another group of researchers report that "platelets drive liver fibrosis through the direct activation of hepatic stellate cells in chronically injured liver."
"We also found that aspirin in the long term, at the low dose — the antiplatelet dose — is reducing — well actually, preventing — fibrosis in the mouse model," Dr. Popov, who was involved in both studies, told Medscape Medical News.
More potent antiplatelet agents — such as clopidogrel (Plavix), prasugrel (Effient), and others currently in the pipeline — could have an even stronger effect against fibrosis, said Athan Kuliopulos, MD, PhD, professor of medicine at the Tufts University Sackler School of Biomedical Sciences in Boston, who was not involved with the study.
"And this is just liver fibrosis," he told Medscape Medical News. "What does it mean for outcome?"
He said that if, as he and his colleagues theorize, platelet activation or action is a primary cause of fibrosis, it might be possible to "bypass the platelet entirely," and target the factor Xa protease.
Dr. Jiang has disclosed no relevant financial relationships. Dr. Popov reports consulting for and receiving research grants from Gilead Sciences. Dr. Kuliopulos is the CEO of Oasis Pharmaceuticals.
The Liver Meeting 2014: American Association for the Study of Liver Diseases (AASLD). Abstract 449, presented November 8, 2014; abstract 778, presented November 9, 2014.
AASLD - Aspirin Might Protect Against Liver Fibrosis
0
Tuesday, November 11, 2014
Posted by HCV New Drugs
FILE UNDER AASLD 2014, HCV NEWS, LIVER FIBROSIS
Medscape Medical News from: The Liver Meeting 2014: American Association for the Study of Liver Diseases (AASLD)
Good Old Aspirin Might Protect Against Liver Fibrosis
Neil Osterweil
November 10, 2014
BOSTON — Will wonder drugs never cease? Aspirin, already touted for its cardiovascular and anti-inflammatory prowess, seems to be flexing its muscles against liver fibrosis, particularly in people at risk for chronic liver disease, according to new research.
"Clinical equipoise is emerging that may justify prospective randomized trials of aspirin and, potentially, other antiplatelet drugs such as antifibrotic agents," Gordon Jiang, MD, a gastroenterology fellow at the Beth Israel Deaconess Medical Center in Boston, and colleagues state in a scientific poster here at The Liver Meeting 2014.
In a population-based cross-sectional study of more than 14,000 adults, there was "a consistent association between aspirin use and less liver fibrosis," Dr. Jiang and colleagues report.
The team drew on the National Health and Nutrition Examination Survey (NHANES) III to look at the association between aspirin, ibuprofen, and liver fibrosis. Fibrosis was measured with four validated noninvasive indices: Fibrosis-4, the nonalcoholic fatty liver disease fibrosis score, the aspartate aminotransferase/platelet ratio index, and the Forns Index.
To see if the association between aspirin and fibrosis protection is stronger in patients most at risk for fibrosis, they did additional analyses in patients with viral hepatitis, heavy drinkers, and patients with fatty liver disease.
On the four measures, the use of aspirin was consistently associated with lower stages of liver fibrosis. In contrast, there was virtually no link between ibuprofen use and liver fibrosis.
Similarly, in an analysis of patients with and without chronic liver disease (hepatitis B or C infection, more than 5 alcoholic drinks per day, or suspected nonalcoholic steatohepatitis), aspirin but not ibuprofen was consistently associated with lower stages of fibrosis.
For patients with or at risk for liver disease, compared with those without risk factors, there was about a 5-fold increase in the negative coefficient for the interaction between aspirin use and liver fibrosis. This suggests that the protective effect of aspirin is much larger in patients with chronic liver disease, said researcher Yury Popov, MD, PhD, assistant professor of medicine at the Beth Israel Deaconess Medical Center.
The researchers acknowledge that the study was limited by the observational design, and by that fact that the NHANES III data were limited to 1 month of drug use, "whereas the protection against liver fibrosis likely requires long-term use."
They speculate that the antiplatelet activity of aspirin, rather than its anti-inflammatory properties, likely account for its positive effects on fibrosis.
"Our observations support emerging experimental and clinical evidence for a pathologic link between platelet activation and liver fibrosis," they write.
In a separate study, also presented here, another group of researchers report that "platelets drive liver fibrosis through the direct activation of hepatic stellate cells in chronically injured liver."
"We also found that aspirin in the long term, at the low dose — the antiplatelet dose — is reducing — well actually, preventing — fibrosis in the mouse model," Dr. Popov, who was involved in both studies, told Medscape Medical News.
More potent antiplatelet agents — such as clopidogrel (Plavix), prasugrel (Effient), and others currently in the pipeline — could have an even stronger effect against fibrosis, said Athan Kuliopulos, MD, PhD, professor of medicine at the Tufts University Sackler School of Biomedical Sciences in Boston, who was not involved with the study.
"And this is just liver fibrosis," he told Medscape Medical News. "What does it mean for outcome?"
He said that if, as he and his colleagues theorize, platelet activation or action is a primary cause of fibrosis, it might be possible to "bypass the platelet entirely," and target the factor Xa protease.
Dr. Jiang has disclosed no relevant financial relationships. Dr. Popov reports consulting for and receiving research grants from Gilead Sciences. Dr. Kuliopulos is the CEO of Oasis Pharmaceuticals.
The Liver Meeting 2014: American Association for the Study of Liver Diseases (AASLD). Abstract 449, presented November 8, 2014; abstract 778, presented November 9, 2014.
I take Acetaminophen - you pay extra for the Tylenol brand name but you can buy generic and it's the same deal. It comes in 325 mg pills
2 will usually work so that adds up to 650 mg
This may sound hippy dippy but I had been dealing with chronic pain caused by neuropathy - caused by Hep C - and the best solution that is working for me now is meditation
You can start off slowly, just concentrate on the breath. There are many exercises that you can download for free (5 min, 10 min)
The pain was preventing me from sleeping but the meditation or mindful attention has remedied that
Good luck - Advil used to be my wonder drug for headache, muscle ache and insomnia but it is the Worst thing (besides drinking alcohol) that you can take for your liver
2 will usually work so that adds up to 650 mg
This may sound hippy dippy but I had been dealing with chronic pain caused by neuropathy - caused by Hep C - and the best solution that is working for me now is meditation
You can start off slowly, just concentrate on the breath. There are many exercises that you can download for free (5 min, 10 min)
The pain was preventing me from sleeping but the meditation or mindful attention has remedied that
Good luck - Advil used to be my wonder drug for headache, muscle ache and insomnia but it is the Worst thing (besides drinking alcohol) that you can take for your liver
If you have cirrhosis, both are bad.
I take pain pills without the Tylenol, but when it comes to pain from inflammation I take 500 mg of Naproxen. I don't take more than two of these in a week. My hepatologist and rheumatologist both advise this for pain from neuropathy and arthritis.
However, it all depends and is very individual.
I take pain pills without the Tylenol, but when it comes to pain from inflammation I take 500 mg of Naproxen. I don't take more than two of these in a week. My hepatologist and rheumatologist both advise this for pain from neuropathy and arthritis.
However, it all depends and is very individual.
Transplant team/hepatologist said Tylenol only, no more than 2000 mg daily, only if necessary. No Advil.
Tylenol or Advil
My understanding is Tylenol in order to avoid bleeding problems but only limited amount of Tylenol if you have Hep C.
My understanding is Tylenol in order to avoid bleeding problems but only limited amount of Tylenol if you have Hep C.
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