Most patients relapse within the first month so that is the best indicator of SVR that we had.
The only data we have from a similar trial is from LONESTAR.
NOTE: treatment is for shorter duration then your trial.
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Trial: LONESTAR, NCT01726517, GS-US-337-0118; sofosbuvir/ledipasvir with and without ribavirin; phase II.
"Participants: n=100 (planned); aged 18 years and older; HCV infection; genotype 1; chronic; treatment naïve or experienced.
Schedule: Randomised to:
Treatment naïve participants sofosbuvir/ledipasvir, oral, 400mg/90mg once daily for 8 or 12 wks; or sofosbuvir/ledipasvir, oral, 400mg/90mg once daily, with ribavirin, 500mg or 600mg twice daily for 8 wks;
Treatment experienced participants sofosbuvir/ledipasvir, oral, 400mg/90mg once daily for 12 wks; or sofosbuvir/ledipasvir, oral, 400mg/90mg once daily, with ribavirin, 500mg or 600mg twice daily for 12 wks.
Follow-up: Active treatment period up to 12 wks; 3 yrs follow-up.
Primary outcome/s: SVR; safety and tolerability.
Secondary outcome/s: Viral resistance to study drug; viral dynamics; pharmacokinetics.
Key results: For treatment naïve participants: sofosbuvir/ledipasvir 8wks, 12wks and sofosbuvir/ledipasvir with ribavirin respectively, 95% achieved SVR8(a) , 100% achieved SVR4(b), 100% achieved SVR8; for treatment experienced participants: for sofosbuvir/ledipasvir and sofosbuvir/ledispavir with ribavirin respectively, 95% achieved SVR4, 95% achieved SVR4.
(a) Sustained virologic response 8 weeks after completing therapy.
(b) Sustained virologic response 4 weeks after completing therapy.
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Trial: ION-2, NCT01768286, GS-US-337-0109; sofosbuvir/ledipasvir with and without ribavirin; phase III.
Sponsor: Gilead Sciences.
Design: Randomised.
Participants: n=400 (planned); aged 18 years and older; HCV infection; genotype 1; chronic; treatment experienced including patients who have previous failed NS3/4A protease inhibitor plus peginterferon/ribavirin regimen.
Schedule: Randomised to sofosbuvir/ledipasvir, oral, 400mg/90mg once daily for 12 or 24 wks; or sofusbuvir/ledipasvir, oral, 400mg/90mg once daily, with ribavirin, 500mg or 600mg twice daily for 12 or 24 wks.
Follow-up: Active treatment period up to 24 wks; 3 yrs follow-up.
Primary outcome/s: SVR; safety and tolerability.
Secondary outcome/s: Kinetics of circulating HCV RNA; viral resistance to study drug; pharmacokinetics.
Expected reporting date: Q4 2014.
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You should have very good odds for cure.
Best of luck to you!
Hector
I just had my 12-week-post-end-of-treatment blood draw two days ago. I was in the ION-2 12-week without ribavirin group. When the research clinic calls me within the next couple of weeks to ask me to schedule my 24-week-post blood draw, or when they call saying "there was a problem with your labs and we need to repeat your blood draw", I'll be sure to post.
My anxiety level is a lot less now than it was 6 weeks ago. I was able to convince my family physician to order me up a viral load test, good down to 2IU/ml, at 6-weeks post treatment. Those results showed that I was undetected at EOT+6. That was quite the relief for me because I didn't go undetectable until treatment week 6, I only treated for 12 weeks, I only took the SOF/LDV without RBV, and I was a 3X treatment failure, one of which included a protease inhibitor. However, because of all of that, I do still have some anxiety about this EOT+12 test.
But in your case, you, having gone undetectable at week 2 of treatment, getting 24 weeks of SOF/LDV plus RBV, I'd say are now free to go about a normal life. Don't sweat it. Relax. Enjoy your life.
I just read your post and I just wanted to comment because it is the same for me to a T...I too received a bad blood transfusion at birth being born at 30 weeks I am now 27 and have slightly elevated enzymes just now and not treated yet and am looking to get into a interferon trial as I have 2 young kids and the easier the better! I hope SVR for you and everyone else for that matter. It makes me hopeful to hear you say u still did a bit of excercise as I am on the go all day pretty much with 2 young kids. Sleep well for me lack there of hoping that will get better with baby getting older! Congrats on completing treatment! All the best