UNDETECTABLE!

I'm on the Sofosbuvir/GS-5885/Ribaviran study for 12 weeks.  My one week viral load test just came back today ~~ undetectable!

[Eki1]

Oh, and I failed triple therapy last spring.  I want to thank this group for all the great information, support, and help.  THANKS SO MUCH!

There are about seven posters who are stellar, and I'm afraid to name them for fear of leaving one off....but I'm grateful for all the time and energy you put into making this a great community.

[pooh55811]

This is wonderful news, Eki, and I am hoping this time you will attain SVR. Sending positive thoughts and energy and wishes your way.   : )

[gsx1250fa]

Congrats. I am on the same study and went UND at week 4. My 1st and 2nd week blood draw were <25. No 3rd week draw. 4th week draw UND. First time I have achieved UND  in 4 treatment attempts.

[UKgirl55]

WOW...one week!!!! Unbelievable. I'm in week 13. UD @ week 2. Had my 12 week UD report yesterday :-)

You must be over the moon!!!!

[hepcat60]

Glad to hear.  I got the same news last week from week 2 labs.   Hang in there this is good news.

[HectorSF]

Nice job! You are on your way. Remember to take all doses and you have a great chance of SVR.

Sofosbuvir works like a charm doesn't it.

I'm a previous genotype 1b null-responder with cirrhosis to peg-INF + Ribavirin

'An Open-Label Study to Explore the Clinical Efficacy of GS 7977 With Ribavirin Administered Pre-Transplant in Preventing Hepatitis C Virus (HCV) Recurrence Post-Transplant'
Conditions: Hepatitis C;   Hepatocellular Carcinoma
Intervention: Drug: GS-7977+RBV

Had a viral load of 692,000 day 1
One week - 581
Two week - <25 UND     4.44 log drop
I am now on week 24 of treatment.

Cheers!
Hector

[racky2012]

Its always nice to see an undetectable post it is a real good feeling when you get that news good luck with the rest of your treatment

Best of luck to you

[balagan51]

'm not in the Gilead trial, (congrats to all doing well with it)
was just trying to get some thoughts on viral loads,. I don't know if my numbers are good or not
I'm in another study, but thats irrelevent.
When I was screened my Vl was 8.9 million
After one week it was 200.

Would one of guys more experienced with this stuff care to give me their thoughts on this number. Is this good?

All my enzemes returned to normal for the first time since being diagnosed  in 1996 too,

exercise fatigue and brain fog (min.)

Thanks so much

GT 1A Cirrhotic CT. failed IFN/RIBO prior

Mike

[Eki1]

Hi Mike,

Well, you're looking at a logarithmic drop, not really a straight number drop.  Yes, I'd say that your numbers are good for one week.  You have more than a 4 log drop, so that's very good.

Your next test result, and the one after at four weeks will be very interesting.  The virus replicates very quickly...and it doesn't check itself to see if it has a perfect copy.  That means that it gets all sorts of defective replicas, but every once in awhile it gets lucky and replicates one that's resistant to your meds.

At least, that's how my GI/Hepatologist explained it to me.

Ike

[balagan51]

Thanks Eki1
I should be getting my two week kabs thrusday.
Then i dont get tested again till week 4
On IFN my numbers doubled in 3 months!
I havent seen mormal enzemes till last week either
You are right on, Undectable is the only number that coundts!
Again, thank yo for taking the time to explain. i really appreciate it
I havent allowed myself to get too worked up ovre it
  I'm cautiously optimistic.


Mike

[chrisy64]

Beautiful news!  Every victory is cause for celebration for all of us!!!  

[ceanothus]

Eki, I'm so happy to hear your great news, wow, UND in one week! Congratulations! That's amazing, and also really nice to know just in case I'm not SVR. I have just a few more weeks before that critical 24 weeks post-EOT test. It will probably be good, but I can't let myself count on it yet, not after all my previous failures. Do continue to give us news of how it's going.

[balagan51]

week 2  
Viral Load >25
Enzymes all WNL

cautiously optimistic.....

[Eki1]

VERY GOOD SIGN!  

Not perfect...but definitely on the right track!

Oh, and some labs interchange 25.  I'm no expert, but I've never seen that before.