Just returned from my Prove 1 48 weeks post-tx follow-up, which was the FINAL step in the trial. I'm now officially finished.
The staff were excited to tell me that they were starting Phase 3 in a month or so. The final trial design is, or is very close, to FDA approval. They anticipate enrolling the initial cohort of naive subjects in January, to be followed by a second cohort of non-responders a little after that. No details on the specifics of trial design except that all non-control arms will be triple therapy. There will be no non-Riba arms, which should be good news for prospective subjects.
Anyone who wants to get into the Phase 3 trials should be contacting their local clinics now. Given the much larger Phase 3 cohort, its likely that there were be more clinics involved that was the case with Prove 1 and 2, but the clinics that participated in these earlier trials are the best place to start. If your local clinic is fully booked, its likely that they will know of other clinics who are running Phase 3 groups, given that they have al been to initial conferences on Phase 3 already.
Full disclosure: I was a geno 1B with a VL of 24,000,000 and Stage3 liver histology, enrolled in the 12+12 arm of Prove1. UND around day15, and SVR at 36 weeks post-tx. I'll soon know the 48 weeks post-tx, but there's no reason to suspect its not still SVR. I'm fully recovered from the rigors of the tx, and feeling better than I've felt in many, many years. I wish the same for all of you potential Phase 3 lab rats :-)