Aa
A
A
Close
Avatar universal
Viral-Breakthrough
Has anyone ever had this happen while on tx? I started tx 9 months ago, vl was steady decline. I started at 636,000 (type 1a). At month 7 it was 2. It 8th month went back up to 245. Now dr says I havve to do another year!!!!! any advice?
Cancel
7 Answers
Page 1 of 1
Avatar universal
Immediately get re-tested to make sure it's not a false positive. Many will not consider this a viral breakthrough unless you have two consecutive positives within a few days of each other. In addition -- but not instead of -- ask your doctor to have the lab re-run the test using the same blood sample. Often they keep some extra blood for a week or so.

You only mention two tests -- month 7 and month 8. What about earlier viral load tests? Were you tested at weeks 4, 12, 24, etc? If so, what were the values and exactly what viral load tests are you using? Also, do you know what stage liver damage you are?

-- Jim
Comment
Cancel
Avatar universal
Comment
Comment
Submit Comment
Avatar universal
Also, when you say your viral load at month 7 was "2" -- I assume you mean you were non-detectible at month 7 using a test that has a sensitivity of 2 IU/ml. The only one I'm aware of that sensitive are two tests by LabCorp. Are you using LabCorp and do you know the name of the test you took.
Comment
Cancel
Avatar universal
Comment
Comment
Submit Comment
Avatar universal
Yes, but for me it was a breakthrough in the millions.  It has been observed that there can be variations in VL measurements.  I was told that the best time to have a PCR draw is just prior to your next injection (i.e. day of or day before) and try to keep each draw consistent (i.e. same day, same time) as possible throughout tx.
Comment
Cancel
Avatar universal
Comment
Comment
Submit Comment
Avatar universal
Yes, at first, when I went from 1.8 million to 2.4 million, I was allowed to continue until I had returned to full dose of the meds, then I was given 12 wks on full dose.  After 12 wks, when I went from 2.4 million to 4.4 million, I was pulled from tx since VL was continuing to climb.  I believe that being at 100,000 U of Procrit a wk to fight the anemia also played into the decision.

Because of the VL breakthrough and the high dosage of rescue meds there is no further option, other than transplantation, currently available until new meds arrive.
Comment
Cancel
Avatar universal
Comment
Comment
Submit Comment
Avatar universal
Was your breakthrough while you were on tx? if so what did the doctor say you should do?
Comment
Cancel
Avatar universal
Comment
Comment
Submit Comment
Avatar universal
We discussed this with you about a week ago right?
The 615 test?
Now the doctor says you have to do another year.
You are in month 9.
Please confirm that the doctor means that you simply continue for another year.
You need to have another sensitive pcr in about a week.
If that is positive to any degree there is no point in just ploughing on.
Omce breakthrough has occurred the virus is back in control of the game.It has developed a resistance to the therapy,and longer therapy will probably not ,in my opinion ,bring you an SVR.
At the very least you should change interferons.
Are you taking Pegasys?
You should condider switching to Pegintron which has a slightly different action and hits harder.The dose is variable too, and perhaps four weeks of .05ml could get you where you want to be.
You can discuss my suggestion with your doctor-but don't tell him it came from an internet chat board or he won't take you seriously.
Comment
Cancel
Avatar universal
Comment
Comment
Submit Comment
179856 tn?1333550962
I'm sorry you got these results.  If I was you - before I had a giant panic attack, I'd get retested to make SURE those damn cooties were floating about or NOT.

Comment
Cancel
179856 tn?1333550962
Comment
Comment
Submit Comment
Your Answer
Avatar universal
Answer
Know how to answer? Tap here to leave your answer...
Answer
Submit Answer
A
A
Recent Activity
4705307 tn?1447973922
Blank
timothy141 Amassing and amazing, to se... Comment
10 hrs ago
317787 tn?1463415842
Blank
Dee1956 commented on MH Community Mgr's status
13 hrs ago
707563 tn?1455827280
Blank
Emily_MHModerator uploaded new photos
13 hrs ago
Blank
Weight Tracker
Track your weight over time
Start Tracking Now
Top Hepatitis Answerers
317787 tn?1463415842
Blank
DC
683231 tn?1438659664
Blank
Auburn, WA
1815939 tn?1377995399
Blank
Avatar universal
Blank
446474 tn?1446351282
Blank
San Francisco, CA
163305 tn?1333672171
Blank
Rural Mural, CA
Hepatitis C Community Resources
RSS Expert Activity
233488 tn?1310696703
Blank
Marathon Running Done Over Many Yea...
05/15 by John C Hagan III, MD, FACS, FAAOBlank
233488 tn?1310696703
Blank
New Article on Multifocal IOL vs &q...
05/15 by John C Hagan III, MD, FACS, FAAOBlank
748543 tn?1463449675
Blank
TMJ/TMJ The Connection Between Teet...
01/15 by Hamidreza Nassery , DMD, FICOI, FAGD, FICCMOBlank
Top Hepatitis Answerers
317787 tn?1463415842
Blank
DC
683231 tn?1438659664
Blank
Auburn, WA
1815939 tn?1377995399
Blank
Avatar universal
Blank
446474 tn?1446351282
Blank
San Francisco, CA
163305 tn?1333672171
Blank
Rural Mural, CA