Viral Breakthrough

[slideman]

Now that triple tx has been underway for a while, has anybody heard of any viral breakthrough issues? That happend to me my first tx. Just wondering. Its a real bummer to have that after being und, and doing tx for months just to find out it failed while you were going through all the sides for nothing.

[tiredturkey19564]

Just did my 20th dart. I will have my 24th week VL done right after XMAS. I'm a previous non responder, VL at 4 weeks 1 million. I'm on VIC, 12 wks undected. I wasn't even thinking of break thur. Has anyone finished? My doc has 14 of us, and only 1 nonresponder, all of us on vic.

[rockymoe]

Yes I got the plocebo the first time and then did the rollover. I also got the rash real bad si if I had not broke thru I would have been pulled due to the rash, A top liverman in Boston told me to wait till Bocep was approved and to do that so that is what I am doing. I go to a clinic that all they deal with is HVC and HIV so I think I am in good hands.

[somuchmore2]

These post give me much encouragement to push through the on-going peg/riba so thank you. I'll get a new RNA read before Thanksgiving and if still und my mental outlook will be excellent.

It is truly a blessing to think this HCV could be und after completion of this third treatment. My status of disease place me has a hard case to cure: geno 1a, il28 tt, stage iv liver, twice non-responder to treatment.

[sandysf]

rocky, if you were on a trial are  you 100% sure you actually got the Tela?  I find it unusual that a doc would treat you with another PI.  

[rockymoe]

I broke thru at 6 weeks on Telaprevir trial. I'm now on VIC

[willbb]

Slideman &somuchmore :

The odds of breakthrough on the P.I"s  seems rare and as hrsep  mentioned there was the one member and I believe l possibly one other(howeverI may be mistaken on that)

In the Tela (advance trial) for naives
Jasmine correctly stated that 7 %  either had to stop because of the futility rule(ie not being <1000at week 4 or week12,or still having virus at week 24 ) or having a breathrough at some point during tx. I don"t believe there was a breakdown of the two

In the Tela (realize ) trial  for prev. tx. experinced

1% of prev. relapsers
15% or prev. partials
and 50% of prev. nulls

had  to either stop because of futility rule  or breakthough....again I don't think there was a breakdown..

Again ..seems like breakthroughs are uncommon
Will

http://www.fda.gov/ForConsumers/ByAudience/ForPatientAdvocates/ucm256328.htm


I only

[slideman]

That sounds like good odds!! I know its very soon yet to really get a lot of results. But it dosent look like there have been too many on here anyway.

[hrsepwrguy]

Do you remember the member cctex, I believe she had a breakthough, but she stopped posting shortly after reporting it, that is the only breakthough of people on tri tx that I can remember since I have been this site.

[JasmineT]

No stats to share.  Did ask this question of my doc last week.  She said that the only patients she has so far on triple that have had a breakthrough so far were not taking their meds.  She gave an example of one that had started treatment, knowing she had already booked a cruise for 3 months in, then stopped taking her pills for a few days to pack and enjoy the cruise.  I don't think she has anyone that finished completely yet.

Would be interesting to know if others have more details.  I believe the stats I have seen show about 7% for my geno and my status/response but it varies.

[sandysf]

I will bump you up here on this post,  I have not heard of anyone on this forum having a breakthrough yet,  but if you look at INC/Vitrelis study data the breakthrough % are in there I believe.

[somuchmore2]

I have same question.

Current und after Incivek, but wondering when and how to watch for breakthrough........

Hope your post gets traction.