WBC count was 1.5 and went to 23 after four shots of Neupogen

[hcvJames]

I was pulled from tx for the third time in 5 mths due to low WBC and ANC. Last time, 4 shots ago, I took 4 shots of Neupogen in a little over a week of a two week hiatus. The WBC went from 1.5 b4 Neup to 23 after!

Or so they claim, I'm skeptical until I pinpoint the particular CBC and get a copy.

Does this sound possible?
Given I'm under full dose peg and co-peg, pulled from tx 3x's now for low WBC, what in the world could possibly be the down side to having 23k WBC under Neupogen??? (eventually figure out a maintenance dose and boogie till you puke.)

btw as of 05/03/10 :
- WBC was 1.5, ANC (25+8)*1.5=490
  AND
- still UND! to the limits of the test, at least.
RNA by PCR <43 iu/ml
Log of HCV RNA <1.6
lost track of what that last means except around 1 is ideal?
mention square root, logarithmic, etc., to me, eyes glaze, head falls forward into the pudding, and warm mush seeps from the ears

Thanks for any feedback.

[hcvJames]

If I understand your question correctly. Nope, the neupogen doesn't stop until treatment stops. It's the interferon and riba that's lowering your wbc and neup doesn't last long, 2 or 3 days generally, then your wbc falls like a rock again. I took one a week, I could have easily taken two but ... it, well, didn't work out that way. All the best.

[limedee]

i have been on neupogen for months 1st 3 shots in 3 days + now 1 a week but wbc not holding for a week any more dr said maybe 2 x a week when do do stop is ther an end to th neutropenia???? i got this from 20 weeks of i.v ????

[newleaf09]

I did keep records of my ANC after a Neulasta shot.  Neulasta is same thing as neupogen, just a whole lot more expensive and is pegylated to keep it in the system longer.  My ANC went from 1.32 to 13.38 after the first single shot.  The next time it was .640 to 12.  It's pretty amazing.  You probably did not need 4 shots, but now they know how you respond to neupogen and they can tailor it a little better for you.  Believe the labwork.

[orphanedhawk]

I wish my memory wasn't so faulty but I do recall my heptalogist telling me neupogen would cause my wbc to rise but only temporarily. That's why I had to keep taking the stuff which I personally hated. But you're right that each person needs the dosage tailored to fit.
He also believed it was more important to watch my absolute neutrophil count than the wbc.

Don't worry about the mush, as long as you keep your sense of humor.
OH