Watch Out

The interaction caused by grapefruit compounds lasts for up to 24 hours and its effect is the greatest when the juice is ingested with the drug or up to 4 hours before the drug. [10]

It is demonstrated for the first time that lemon juice significantly inhibits by 60 ± 3% the CYP3A4-mediated oxidation


http://cat.inist.fr/?aModele=afficheN&cpsidt=1067148

[Rockerforlife]

Grapefruit juice impairs the body's normal breakdown of several drugs, allowing them to build up to potentially excessive levels in the blood. 2 Saquinavir mesylate as well as other protease inhibitors may be affected


http://www.empowher.com/media/reference/protease-inhibitors

[Rockerforlife]

People taking any protease inhibitor should either avoid taking vitamin C, or have their protease inhibitor levels checked whenever they start (or stop) taking vitamin C.

[all_is_well]

Rocker:
How did you make it with your work issue?

To All:
Does ti mean we are not supposed to take grapefruit during tx?

Could this be the reason why I didn't get UND at week 12? Every day since wk 7 of my tx I started to put the juice of 1 grapefruit into my morning smoothie.

Like I said I am 1b, day 1 was VL 13,500,000; wk5 = 5,400 and wk12 <15, but still detectable????

[Rockerforlife]

Grapefruit juice is not known to contradict to SOC drugs ...its the PI`s that may be cause for concern..if it was me...id stop the grapefruit and lemon juice to be on the safe side....BTW....some drug reactions with grafefruit and antidepreeants are toxic too....stop the grapefruit to be safe

[Tippyclubb]

It was explained to me that grapefruit may cause a allergic reaction with the PI's.  They did not mention lemons and I put lemon or lime in my water daily.  Now I'm not suppose to be doing that?  OOh **** one more thing to worry about!  Lol !

[GreatBird]

There are a number of medications that one should not have with grapefruit. Other citrus are probably okay:

>>Oranges, lemons and limes are less likely to interact with medications. However, tangelos, related to the grapefruit, and Seville oranges affect the same enzyme as grapefruit juice. Seville oranges are often used to make orange marmalade, and so be mindful when selecting this spread for your toast.<<

From:
http://drugs.about.com/od/medicationabcs/a/gjuice_drugs.htm

[Rockerforlife]

It is demonstrated for the first time that lemon juice significantly inhibits by 60 ± 3% the CYP3A4-mediated oxidation