Hepatitis C Community
What is Occult hep c
About This Community:

This forum is for questions about medical issues and research aspects of Hepatitis C such as, questions about being newly diagnosed, questions about current treatments, information and participation in discussions about research studies and clinical trials related to Hepatitis. If you would like to communicate with other people who have been touched by Hepatitis, please visit our new Hepatitis Social/Living with Hepatitis forum

Font Size:
A
A
A
Background:
Blank
Blank
Blank
Blank Blank

What is Occult hep c

   I have heard the term before on this forum. What exactly is Occult hep c ???

Bobby
Related Discussions
2 Comments Post a Comment
Blank
Avatar m tn
The term "occult" used here means "hidden", and in the sense used here it is describing any Hep C that remains below current blood test detectability levels (i.e. - "hidden").

If you go over to the Health Page here at MedHelp that is dedicated to Occult Hep C, the following two papers should give you a pretty good definition and overview:


"Occult Hepatitis C virus persistence: identification and characteristics.[PDF]  (2/06)"

and

"Occult hepatitis C virus infection: A new form of hepatitis C.  (11/06)"


TnHepGuy
Blank
Avatar f tn
This answered most of the questions: http://www.wjgnet.com/1007-9327/12/6922.asp

Occult hepatitis C virus infection: A new form of hepatitis
Abstract

Occult hepatitis C virus (HCV) infection is a new recently characterized entity. This occult infection can be present in two different clinical situations: in anti-HCV negative, serum HCV-RNA negative patients with abnormal liver function tests and in anti-HCV positive subjects with normal values of liver enzymes and without serum HCV-RNA. This review describes recent studies of occult HCV infection in both kinds of patients.

CHRONIC VERSUS OCCULT HEPATITIS C

Once occult HCV infection is identified, one important question is if the clinical characteristics of this infection differ from those usually found in chronic hepatitis C. Trying to answer this question, the biochemical, virological and histological features of a group of 68 patients with occult HCV infection were compared with those of a group of 69 patients with histologically proven chronic hepatitis C[14]. Groups were matched with respect to gender, age and known time duration of the disease. Triglycerides and cholesterol values were significantly higher in occult HCV infection, while alanine aminotransferase, gammaglobulin, alpha-fetoprotein and iron levels were significantly higher in patients with chronic hepatitis C. The number of patients who had necroinflammatory activity and fibrosis in the liver biopsy was significantly higher in the group with chronic hepatitis C than in the group with occult HCV infection, but no difference was found in the percentage of patients with liver steatosis between both groups. Finally, as could be expected, the percentage of HCV-infected hepatocytes (determined by in situ hybridization) was significantly lower in patients with occult HCV. Thus, it was concluded that occult HCV infection is a milder disease, with less liver damage than chronic hepatitis C. Nevertheless, as patients with occult hepatitis C may present dyslipidemic disorders, studies on the natural history of occult HCV infection should be performed to prove the role of occult HCV as the cause for liver injury in these patients.



Blank
Post a Comment
To
Recent Activity
874521 tn?1424120397
Blank
opus88 commented on READY
3 hrs ago
406584 tn?1399591666
Blank
10356 commented on READY
8 hrs ago
684676 tn?1458487571
Blank
onthefence commented on READY
8 hrs ago
Blank
Weight Tracker
Track your weight over time
Start Tracking Now
Top Hepatitis Answerers
317787 tn?1460223707
Blank
Dee1956
DC
446474 tn?1446351282
Blank
HectorSF
San Francisco, CA
Avatar m tn
Blank
can-do-man
IN
683231 tn?1438659664
Blank
flyinlynn
Auburn, WA
1815939 tn?1377995399
Blank
pooh55811
163305 tn?1333672171
Blank
orphanedhawk
Rural Mural, CA
Hepatitis C Community Resources
Top Hepatitis Answerers
317787 tn?1460223707
Blank
Dee1956
DC
446474 tn?1446351282
Blank
HectorSF
San Francisco, CA
Avatar m tn
Blank
can-do-man
IN
683231 tn?1438659664
Blank
flyinlynn
Auburn, WA
1815939 tn?1377995399
Blank
pooh55811
163305 tn?1333672171
Blank
orphanedhawk
Rural Mural, CA