Aa
A
A
Close
806995 tn?1265826776
Will suppressing IR slow down liver fibrosis?
My glucose level are on the high side (6.5, 5.2, 6.1 mmol/l at -1, 1, and 4 weeks of TX respectively). Hence, I suspect I'm insulin resistent. I'm genotype 1 and have also HIV. At 4 weeks I only had a 0.23 log drop in VL. I may well be a non-responder, and perhaps it is related to a possible IR.

In November 2008 the results of a double blind test was published, where IR geno 1 HCV where treated with additional Metformin to suppress the IR. It worked, but mainly for women and fat people. However, I'm neither.

http://www.natap.org/2008/AASLD/AASLD_41.htm

Nevertheless, I'm wondering, would taking something like Metformin perhaps slow down my liver fibrosis? I want to wait for the new meds to arrive in two years time, but perhaps the increasing fibrosis will catch up with me. I hope that if I turn out to be IR, suppressing it will give some relief in this respect.


Cancel
3 Answers
Page 1 of 1
Avatar universal
http://news.yahoo.com/s/hsn/20100610/hl_hsn/olddrugsmayhavenewuseagainsthepatitisc

You can do some research and download the study in PDF format.
Comment
Cancel
Comment
Avatar universal
Comment
Comment
Comment
Post Comment
Avatar universal
IR is a predictor of SVR.  HCV slowly damages the mitochondria through a process of oxidative stress. Aerobic exercise helps produce more mitochondria and a high-protein diet boosts the benefit of exercise, which decreases insulin resistance.
Being insulin resistant impairs your ability to achieve a sustained response to Chemotherapy drugs peginterferon and ribavirin... Adding Metformin before and during Hep C treatment increases your odds of clearing...
IR can be the cause of steatosis & fibrosis in genotype 1 patients.  So, yes taking Metformin could slow down fibrosis.  
How do you reduce Insulin Resistance & manage blood sugar?
1. Take Vitamin K- It is found in brussel sprouts, brocolli, & dark leafy greens.
2. High intensity exercise- Lift weights & ride your bike.
3. Eat high fiber foods- fortified cereals
4. Consume Citrus Peel Extract
5. Take Alpha Lipoic Acid supplements- Also Flaxseed is a good food source as well
6. Low glycemic index diet
7. Eat Chromium
8. Resistance Training
9. Yoga
10. Use Turemic when you cook
11. Deep restorative sleep
12. Low grain, NO SUGAR diet
13. Supplements- Gymnema sylvestre, bitter melon, fenugreek, banaba, & cinnamon
14. Vanadium
15. Omega 3-fatty acids, fish oils
Comment
Cancel
Comment
Avatar universal
Comment
Comment
Comment
Post Comment
Avatar universal
agreed that the '08 metformin study did not make a strong case for adding metformin in all patients, however you might also want to  look at a recent Khattab'10 study that looked at  adding pioglitazone in geno 4s with HOMA1 gt 2.

http://www.ncbi.nlm.nih.gov/pubmed/19919569

They measured across-the-board improvement in SVR rates 60% vs 39% significant at 0.04. Geno 4s seem to be particularly susceptible to IR-related effects so this may not generalize. Your glucose levels seem pretty high - did your Dr. confirm a diagnosis of diabetes? The combination of IR  HIV and  HCV is not a good one as both IR and HIV have been associated with rapid progression.  Anything you can do to control/improve the glucose levels seems worth pursuing. Cory's list is an excellent start and talking to your Dr. about adding metformin/pioglitazone seems prudent.
Comment
Cancel
Comment
Avatar universal
Comment
Comment
Comment
Post Comment
Your Answer
Avatar universal
Answer
Do you know how to answer? Tap here to leave your answer...
Answer
Answer
Post Answer
A
A
Recent Activity
189897 tn?1441130118
Blank
Sandman2 commented on Anxiety disorder - am...
8 hrs ago
317787 tn?1473362051
Blank
Dee1956 DA DA DA!!! 105 and a half... Comment
14 hrs ago
Avatar universal
Blank
prayer33 ... Comment
Sep 25
Blank
Weight Tracker
Track your weight over time
Start Tracking Now
Top Hepatitis Answerers
317787 tn?1473362051
Blank
DC
163305 tn?1333672171
Blank
Rural Mural, CA
446474 tn?1446351282
Blank
San Francisco, CA
Avatar universal
Blank
1747881 tn?1358189534
Blank
Greeley, CO
2059648 tn?1439770265
Blank
Hepatitis C Community Resources
RSS Expert Activity
233488 tn?1310696703
Blank
Marathon Running Done Over Many Yea...
05/15 by John C Hagan III, MD, FACS, FAAOBlank
233488 tn?1310696703
Blank
New Article on Multifocal IOL vs &q...
05/15 by John C Hagan III, MD, FACS, FAAOBlank
748543 tn?1463449675
Blank
TMJ/TMJ The Connection Between Teet...
01/15 by Hamidreza Nassery , DMD, FICOI, FAGD, FICCMOBlank
Top Hepatitis Answerers
317787 tn?1473362051
Blank
DC
163305 tn?1333672171
Blank
Rural Mural, CA
446474 tn?1446351282
Blank
San Francisco, CA
Avatar universal
Blank
1747881 tn?1358189534
Blank
Greeley, CO
2059648 tn?1439770265
Blank