You don't need 20 grms af fat for telepravir

Many times I questioned the clinic nurse And the treating Doctor and they both said it just needs to be taken,with a tall gglass full cream milk or a couple of tablespoons of full cream yougurt,so what has antyone else been told they have to strickly take 20gms of fat.a sI was told that is not the case.

[Jillko59]

I believe it is very important to follow the instructions. I took 2 TBS of macadamia nut oil instead of the food fat. It worked for me!  

[hrsepwrguy]

Effects of Food on Oral Absorption  

The systemic exposure (AUC) to telaprevir was increased by 237% when telaprevir was administered with a standard fat meal (containing 533 kcal and 21 g fat) compared to when telaprevir was administered under fasting conditions. In addition, the type of meal significantly affects exposure to telaprevir. Relative to fasting, when telaprevir was administered with a low-fat meal (249 kcal, 3.6 g fat) and a high-fat meal (928 kcal, 56 g fat), the systemic exposure (AUC) to telaprevir was increased by approximately 117% and 330%, respectively. Doses of INCIVEK were administered within 30 minutes of completing a meal or snack containing approximately 20 grams of fat in the Phase 3 trials. Therefore, INCIVEK should always be taken with food (not low fat)

How should I take INCIVEK?  

Take INCIVEK exactly as your healthcare provider tells you. Your healthcare provider will tell you how much INCIVEK to take and when to take it.  

Take INCIVEK 3 times a day. Each dose should be taken 7 to 9 hours apart.  Eat a meal or snack that contains about 20 grams of fat, within 30 minutes before you take each dose of INCIVEK. Talk to your healthcare provider about examples of foods that you can eat that contain about 20 grams of fat. Always take INCIVEK with food.

http://pi.vrtx.com/files/uspi_telaprevir.pdf

The info above is straight out of the incivek/telaprevir prescribing information sheet, maybe you should show that to the docs

[uncledudeness]

I'm on week 10 and my NP was insistent that i take the 20 grams of fat and to space it out every 8 hours. i'm sure i am not consuming all 20 grams with each pill cuz i just might go postal. i've already punched my stupid smart phone 20 times when the alarm goes off every frikkkkin 8 hours of my life.
when i'm done with the incivek i am gonna fast for a week.

i would also like to find the idiotjerkdopedweabdrooler that came up with the packaging for incivek and shrink wrap him/her in the same wrapper. i also punched the stupid package too. riba rage alert.....

[uncledudeness]

,,,,i meant to say "each dose of incivek" .... not pill.....correction

i think i'm gonna punch the incivek box right now too.....POW that felt better.

[Advocate1955]

My husband received very clear instructions regarding 20 g of fat with each dose of Incivek.  We were told it was crucial in order to assure the best absorption possible of Incivek.
Advocate1955

[Jillko59]

I believe it is very important to follow the instructions. I took 2 TBS of macadamia nut oil instead of the food fat. It worked for me!  

[Ironpony]

A much as we hate these fats, why question it when it is very clearly stated in the Incivek/prescribing information that hrspwguy provided. There are many new members starting Incivek and it would be a shame for them to read this and think the fats are not needed...when they they are crucial in order to assure the best absorption possible of Incivek. (which I was told just as Advocate was how important it is to take with these PI's)

Aside from absorption, my side effects were bad enough if I went too low on the fats or ate too small of an amount... too little fat = erupting volcano!!! (trying not be too graphic here. :))

[orphanedhawk]

Maybe the milk and cream has a much higher fat content down under ?
Here in North America, everyone is being told to take it with the 20grams of fat
.
hrpwr's reply shows the manufacturer's suggestions. They did the trials and testing, and I'd follow their advice.

[HectorSF]

hrsepwrguy said it all.
"The info above is straight out of the incivek/telaprevir prescribing information sheet, maybe you should show that to the docs."

Doesn't get any self evident and definitive than that!
As we used to say say in the IT world...when in doubt read the manual!

Maybe the doctor should learn how to prescribe Incivek correctly before treating people with it? What else doesn't he/she know about treating with Incivek?

Hector

[Ilove2shop72]

My dr says eat 20 grams of fat before taking and that is what I do. I am into my third week of treatment and doing great.  I am doing triple treatment (Incivek).  I went for 2 wk check up and my blood counts were good and ALT and AST were almost back to normal. Before treatment in the 300's.  I feel great except for extreme anal itching.  OMG. Dr says after 12 weeks are done it will get better. I hope so!  Follow 20 gr of fat rule and you should do great. It is tough but will be so worth it.  Good luck to you.

[copyman]

Like I have posted here many times I took my pills with a glass of "whole" milk.

Not saying it is right for everyone but it worked for me.

[hrsepwrguy]

WHY RISK IT ??????

When the prescribing instructions clearly state take with 20 grams of fat.

You took a risk and got by with it but please stop encouraging people to not follow prescribing information, it is reckless and irresponsible

[can-do-man]

In the trial I was in one person become SVR with only a few weeks of treatment..... So should that person be telling everybody to follow what he did because he got lucky???

Do you really think that one day these researchers just decided to add 20 grams of fat with a meal or a snack??? Maybe they were bored but I kinda doubt it............

[herrokitty]

are you mad?! I almost need more than 20g to not feel the sides as much. also, why pay $20,000 for pills that are absorbed into your body with fat, and not take it as prescribed by the manufacturer?

[Idyllic]

Have you have treated before?  Ideally your treatment decisions are based on a combination of the level of confidence you have in your doctor, independent research & the prescription information - err...and maybe comparing notes with others.

I encourage you to learn the facts and the study data before you make deviate from them.  According to the link below the PIs were only just approved in Australia. I would ask how many patients your doctor has treated with Telaprevir and what he is basing his assumptions on.

https://www.mja.com.au/journal/2012/196/10/changing-therapeutic-landscape-hepatitis-c

I am not trying to freak you out or anything since there is no way we can know everything walking into treatment.  As time goes by you are going to want the peace of mind this is all going to work and knowing you did everything you could to clear the virus.

Best of luck to you

[charlie2247]

Try avacado, trail mix, peanutbutter and Ritz crakers Just get in to munching. A little medical M will help

[uncledudeness]

i couldn't agree with Hrsepwrguy any more. i too think it is irresponsible to mislead members of this forum when it clearly states that 20 grams of fat is the prescribed dosage. i don't understand why someone would intentionally disregard the recommendations when it comes to such an important requirement.

i truly hope that no one reads this thread and thinks that taking incivek with a glass of milk is the way to go...........................IT IS NOT....

[flcyclist]

The prescribing information is based on years of research through clinical trials done by highly qualified doctors.  If your treatment team is able to present you data or studies to validate their claims, then please post them to allow us to learn.  Otherwise, this sound like very poor advice coming from an ill informed doctor that could potentially compromise your (and others) end result in tx.  

You have to ask yourself, is this a risk you're willing to take and wonder if tx fails, could it be due to not following the prescribing protocol?  If so, good luck.  And if your doctor provides any information to support his advice, please post an update.

[BoceprevirGal]

  "Many times I questioned the clinic nurse And the treating Doctor and they both said.."~  the thing about your statement is this:   Your Doctor and your Nurse arent the ones trying to rid themselves of this nasty, and sneaky virus. If you didn't achieve SVR (aka, you're cured) because you didnt eat the 20 calories of fat, to aid with absorption of Incivek, then these two people who gave this (faulty) advice, wouldn't be the ones who's life has been affected (for the worse) by this mis-imfo.
   Whole cream milk IS a good way to get fat calories though, and most likely two large glasses of cream (Half-and Half) or Heavy Cream would be 20 grams of fat, you just have to measure it, good luck :)

[frijole]

If you haven't started and this is such a big issue, choose Victrelis instead.  There are no high fat requirements.  You must eat something, but just a snack and it doesn't have to be high fat --- but then you might change your b----h to the fact that you have to take it for the duration of the treatment, just not 12 weeks.  

How can you choose not to have a 237% advantage?

[BoceprevirGal]

  Okay, I googled, and an 8 ounce cup of milk almost has 8 grams of fat in it, so it would be 3 8 oz cups of whole milk, or 3 of those very small containers of whole milk, it's very "doable".
  I Treated with the Victrelis, but increased my fat uptake a bit anyhow, and I did gain 10 lbs during my Treatment, but I had very little nausea, because the food in my stomach rly seemed to help. I was a peanut-butter fan also, the nice oily stuff...you can do it!

[hrsepwrguy]

"Therefore, INCIVEK should always be taken with FOOD"

"Always take INCIVEK with FOOD. "

http://pi.vrtx.com/files/uspi_telaprevir.pdf

5.3 Food Effect To achieve optimal exposure, telaprevir should be taken with FOOD.

http://www.fda.gov/downloads/AdvisoryCommittees/CommitteesMeetingMaterials/Drugs/AntiviralDrugsAdvisoryCommittee/UCM252562

[can-do-man]

Maybe Keith is not being clear enough here folks..... FOOD, FOOD, FOOD.
Google that, FOOD!!!

[jules2551]

Food is any substance[1] consumed to provide nutritional support for the body. It is usually of plant or animal origin, and contains essential nutrients, such as carbohydrates, fats, proteins, vitamins, or minerals. The substance is ingested by an organism and assimilated by the organism's cells in an effort to produce energy, maintain life, or stimulate growth

[hrsepwrguy]

food  (fuːd)

nourishment in more or less solid form as opposed to liquid form: food and drink

http://dictionary.reference.com/browse/food

milk
 
an opaque white or bluish-white liquid

this liquid as secreted by cows, goats, or certain other animals

any liquid resembling this, as the liquid within a coconut

http://dictionary.reference.com/browse/milk

[jules2551]

http://www.incivek.com/how-to-take-incivek

How to Take INCIVEK
Take INCIVEK exactly how your healthcare provider tells you. Your healthcare provider will tell you how much INCIVEK to take and when to take it.

    Take 2 INCIVEK pills (a dose) 3 times a day
    Eat a meal or snack that contains about 20 grams of fat, within 30 minutes before you take each dose of INCIVEK
    Each dose should be taken 7 to 9 hours apart. Pick the same time each day to make it easier to remember
    INCIVEK must be taken with peginterferon alfa and ribavirin


Always take INCIVEK with food
If you take INCIVEK on an empty stomach, you may not get enough medicine in your blood to clear the virus. That's why it's important to eat a meal or snack that contains fat, within 30 minutes of taking each dose of INCIVEK.

Examples of foods that contain about 20 grams of fat that could be eaten with INCIVEK include*:

    Bagel with cream cheese
    1/2 cup nuts
    3 tablespoons peanut butter
    1 cup ice cream
    2 ounces American or Cheddar cheese
    2 ounces potato chips
    1/2 cup trail mix


Of course, don't eat any foods that you are allergic to. Also, keep in mind any dietary restrictions you may have.

*The food you eat with INCIVEK should NOT be low-fat.

[BoceprevirGal]

I just wanted to add, that while our bodies are busy, fighting a virus, we need to pay extra good attention to our nutrition (food)~
   It's like when we were kids, fighting the flu...chicken soup :)  The fat that floats to the top of the soup has always been an old Jewish cold/flu remedy~

[hrsepwrguy]

The science behind 20 grams of fat with food, it is not a myth, it comes from years of research.

5.3 Food Effect
To achieve optimal exposure, telaprevir should be taken with food. In a Phase 1 study, when compared with administration following a standard normal caloric meal (21 g fat, 533 kcal), exposures (AUC) decreased by an average of 73% when telaprevir was taken in the fasted state, by 39% following a low-calorie low-fat meal (3.6 g fat, 249 kcal), and by 26% following a low-calorie high-protein meal (9 g fat, 260 kcal). The exposure to telaprevir was increased by 20% when taken following a high-fat caloric meal (56 g fat, 928 kcal) compared with an intake following a standard normal caloric meal.  In Phase 2/3 studies, subjects were advised to consume a regular meal or snack (high fat was not required) within 30 minutes prior to dosing with telaprevir. Based on its prescribing information, RBV is also to be dosed with food. Since RBV is administered twice a day and has a long half-life, it was administered with 2 of the 3 daily telaprevir doses in the Phase 2/ 3 studies.

(cont)

[hrsepwrguy]

5.4 Rationale for Dose Selection As a consequence of its high replicative rate and its error-prone polymerase, HCV exists as a quasispecies. In most subjects, the quasispecies consists predominantly of wild-type virus and minority populations of viral variants with varying levels of resistance to direct-acting antiviral agents, including HCV protease inhibitors such as telaprevir. These variants may have lower level (< 25-fold increase in IC50) or higher level telaprevir resistance. The HCV variants usually exist at a low frequency before the start of treatment because they are less fit (have lower replicative capacity) than wild-type virus.  Two main goals of antiviral therapy applied to the development of telaprevir were (1) to achieve a high enough exposure to inhibit replication of wild-type and lower level resistant variants within an acceptable safety margin, and (2) to maintain this dose for a duration needed to eliminate wild-type and lower level resistant variants in combination with Peg- IFN/RBV treatment. The primary role of telaprevir in a T/PR regimen is to eradicate wild- type and lower level resistant variants, leaving the complementary role of PR to eradicate higher level resistant variants and any remaining lower level resistant variants. Susceptibility of HCV to telaprevir in both treatment-naive subjects and in subjects who have previously failed treatment with Peg-IFN/RBV therapy is expected to be the same.

(cont)

[hrsepwrguy]

The antiviral activity of different dosages of telaprevir, administered as a suspension formulation, was evaluated in subjects with genotype 1 CHC (Study 101). The antiviral response was evaluated after administration of telaprevir monotherapy administered for 14 days at 450 mg q8h, 750 mg q8h, or 1250 mg q12h (Figure 5A). The greatest reduction in HCV RNA was observed with the 750 mg q8h regimen, which corresponded to the highest exposure to telaprevir. Because no clinically relevant differences were observed in the safety profile of the 3 dose regimens, the 750 mg q8h regimen was further explored in 2 subsequent short-term studies using a tablet formulation with about 1.5- to 2-fold improved exposure to telaprevir (Studies 102 and 103). In these studies, telaprevir 750 mg q8h coadministered with Peg-IFN or Peg-IFN/RBV resulted in further increase in telaprevir exposures and greater HCV RNA reduction compared with telaprevir monotherapy (Figure 5B), as well as suppression of telaprevir-resistant HCV variants. Because the telaprevir 750 mg q8h dose was generally well tolerated and not associated with any SAEs or discontinuations due to AEs, and the short-term efficacy was favorable (all 12 subjects achieved undetectable HCV RNA at Week 4 in Study 102), this regimen was selected for further clinical development, and no further dose-ranging studies were performed.

(cont)

[hrsepwrguy]

Exposure-response analyses, including clinical utility analyses28,29, conducted on data from the Phase 2/3 development programs confirmed that the 750 mg q8h dose and the regimen of telaprevir in combination with Peg-IFN/RBV results in telaprevir exposures that provided a good balance between efficacy and safety.  The clinical utility index (CUI) represents a composite of the exposure-response relationships for both safety and efficacy endpoints by defining the probability of clinical success as the difference between the probability of clinical efficacy and the probability of clinical safety over a range of drug exposures. The CUI from Study 108 represents a composite of the probability of achieving a RVR, preventing viral breakthrough (no VBT), and incurring a Grade 2 or greater hemoglobin decrease (Hgb abnormalities), as a function of model- predicted telaprevir exposure (Figure 6). During the construction of the CUI, the probability of RVR and no VBT are weighted by the percentage of subjects who meet these endpoints and go on to achieve SVR (81% for RVR and 77% for no VBT). The probability of the Hgb abnormalities is weighted by the percentage of subjects that meet this endpoint and fail to achieve SVR (24%). This weighting scheme was implemented to objectively scale the individual endpoint probability curves by their relative importance on the probability of clinical success

(cont)

[hrsepwrguy]

The distribution of telaprevir exposures (plotted as the population PK model-predicted average plasma concentrations), are included with the 5th and the 95th percentiles marked as dotted vertical lines. The resulting plot shows a relatively flat CUI indicating that the exposure range of telaprevir obtained from the 750 mg q8h dose in combination with Peg- IFN/RBV results in a good balance between efficacy and safety (Figure 6) The exposure-response relationship for subjects with prior treatment failure from Study 106 showed that the clinical utility index weighted by SVR is relatively flat between the 5th and the 95th percentiles of telaprevir exposure (Figure 7). Furthermore, Phase 3 studies have confirmed that this dose of telaprevir used in combination with Peg-IFN/RBV therapy provides superior SVR rates over those seen with Peg-IFN/RBV therapy alone.

To see the charts follow the link

http://www.fda.gov/downloads/AdvisoryCommittees/CommitteesMeetingMaterials/Drugs/AntiviralDrugsAdvisoryCommittee/UCM252562

[flcyclist]

In your follow up post which disappeared you stated that you grilled your doctor and nurse for at least an hour and they adamantly stated that there’s no need for the 20 gm of fat and they’ve treated many patients over many years.   Unless your treatment team has been directly involved with Incivek trials prior to its release in May 2011, this doesn’t allow much time (1.5 yrs) for any doctor to accumulate data on diet and rates of SVR.    If they were involved in trials and shared their data with you to support this advice, it may bring some credibility to their adamant advice.  If they haven’t been involved in trials, this short interval doesn’t allow enough time to recommend off label advice which could recklessly jeopardize anyone’s success in treatment.   If you failed tx, you would look back and always wonder if this could have impacted the result.  

If you feel comfortable in following this advice, then that’s your call.  But to post this as an encouragement for others to follow this off label advice is wrong and reckless.  This would be akin to saying you’ve never been involved in a car wreck resulting in serious injuries, so why bother putting on the seat belt.  Maybe not the best analogy, but if you want to take a risk, then don’t encourage others to follow.  This is by no means an attempt to attack you in any way - just to correct bad advice.   Good luck to you.  

Take a few minutes to read the good information that hrsepwrguy has kindly provided.

[Diana66]

Guys, not to pour gas on the fire but here is an extract from the Data sheet here in New Zealand:
Telaprevir is orally available, most likely absorbed in the small intestine, with no evidence for absorption in the colon. Maximum plasma concentrations after a single dose of telaprevir are generally achieved after 4 – 5 hours. In vitro studies performed with human Caco-2 cells indicated that telaprevir is a substrate of P-glycoprotein (P-gp).
The exposure to telaprevir was increased by 20% when taken following a high-fat caloric meal (56 g fat, 928 kcal) compared to an intake following a standard normal caloric meal (21 g fat, 533 kcal). When compared to administration following a standard normal caloric meal, exposure (AUC) decreased by 73% when telaprevir was taken on an empty stomach, by 26% following a low-calorie high-protein meal (9 g fat, 260 kcal), and by 39% following a low-calorie low-fat meal (3.6 g fat, 249 kcal). Therefore, telaprevir should be taken with food.

Here is the link: http://www.medsafe.govt.nz/profs/datasheet/i/incivotab.pdf

Which really only shows what I have been told by Jansen's office: that needing to take 20gr of fat is news to them. I am not saying that this might not be the case, I am only saying that the same company gives a very different advice in Autralia and New Zealand. And if this is the case they should put their act together.

From the paragraph above it seems that I need 21grs for 100% availability, 56grs to have a 20% increase

Hence the 237% increase presented in US is certainly a different way to presents results. We all  love statistics and how easy is to manipulate results.

The same paragraph also says that if only 9gr are taken (your one glass of milk and whatever else, exposure will decrease 26%. Is that enough? Maybe!!!! I guess it really depends on how big the person is. You cannot tell me that the same amount is needed for a 50kg person and a 120kg person

[hrsepwrguy]

I'm not going to beat the dead horse, I have produced the science behind the dosage rational, presented to the FDA for telaprevir approval, take it as you wish.

"Is that enough? Maybe!!!!"

Maybe not !!!! WHY TAKE THE RISK, you only get one shot with the PI's and if you fail YOU are the one who still has HEP C

[Diana66]

Talking about how to take it, have you seen the latest that taking it twice per day (1,125mg ) instead of 3 times per day is in fact better?

I guess Incivek will update their site shortly. I only wonder if we will need the 30grms of fat with the 3 tablets?

http://hepatitiscresearchandnewsupdates.blogspot.co.nz/2012/10/twice-daily-incivo-telaprevir-in.html#.UH212m_MjjA

[hrsepwrguy]

October 31, 2009
More than 80% of Hepatitis C Patients Treated in Study C208 Achieved an SVR with Telaprevir-Based Regimens

    83% SVR achieved with twice-daily regimen of telaprevir dosed with PEGASYS and ribavirin
    Results highlight the use of response-guided therapy in managing treatment outcomes
    Similar safety and tolerability observed between telaprevir-based regimens dosed either twice daily or three times daily

BOSTON, Oct 31, 2009 (BUSINESS WIRE) -- More than 80 percent of hepatitis C patients in each arm of the Phase 2 Study C208 achieved a sustained viral response (SVR) with a telaprevir-based regimen according to results of an intent-to-treat (ITT) analysis announced today by Vertex Pharmaceuticals Incorporated (Nasdaq: VRTX). The data from Study C208 will be presented in an oral presidential plenary session at the 60th Annual Meeting of the American Association for the Study of Liver Diseases (AASLD), which began yesterday in Boston. Telaprevir is a hepatitis C virus (HCV) protease inhibitor being developed by Vertex Pharmaceuticals Incorporated in collaboration with Tibotec and Mitsubishi Tanabe Pharma.

(cont)

[hrsepwrguy]

Study C208 explored telaprevir-based regimens dosed either every 12 hours (q12h; twice daily) or every eight hours (q8h; three times daily) combined with either peg-IFN-alfa-2a (PEGASYS(R)) or peg-IFN-alfa-2b (PEGINTRON(R)) and ribavirin (RBV), for 12 weeks followed by an additional 12 weeks of peg-IFN and RBV in a response-guided trial design that included 161 treatment-naïve patients (intent-to-treat analysis) with genotype 1 hepatitis C virus (HCV) infection. Across the four arms, SVR rates were 82 and 83 percent in patients treated with the every 12 hour telaprevir-based regimen (PEGINTRON and PEGASYS, respectively) and 81 and 85 percent in patients treated with the every 8 hour regimen (PEGINTRON and PEGASYS, respectively). For the majority of patients, these SVR rates were obtained with a 24-week telaprevir-based regimen.

"With high SVR rates and similar safety outcomes between the twice-daily and three-times-daily treatment groups, the results from this exploratory study support the future evaluation of telaprevir-based regimens dosed twice daily," said Professor Patrick Marcellin, M.D., from Beaujon Hospital in Clichy, France. "These results also highlight the potential future role for response-guided therapy with the goal of improving treatment outcomes and potentially shortening the duration of therapy for the majority of patients."

Study C208 Results                         RVR* SVR**
TVR (q12h/peg-IFN alfa-2a/RBV) (n=40)  83% (n=33)        83% (n=33)
TVR (q12h/peg-IFN alfa-2b/RBV) (n=39)  67% (n=26)     82% (n=32)
TVR (q8h/peg-IFN alfa-2a/RBV) (n=40)    80% (n=32)     85% (n=34)
TVR (q8h/peg-IFN alfa-2b/RBV) (n=42)    69% (n=29)     81% (n=34)

* Rapid Viral Response: Undetectable HCV RNA at week 4

** Sustained Viral Response: Undetectable HCV RNA 24 weeks after the end of treatment

alfa-2a: PEGASYS

alfa-2b: PEGINTRON

(cont) at the following link

http://investors.vrtx.com/releasedetail.cfm?ReleaseID=420611

[Diana66]

Yep, this one is from 2012, not sure why they needed to repeat it (and they do have different results as well, lower than the ones you have posted and probably morea realistic. Still, 74% is good :)

Janssen Research & Development Infectious Diseases - Diagnostics BVBA (Janssen) will present results from the OPTIMIZE Phase 3 trial for INCIVO® (telaprevir), during a late-breaking poster presentation at the 63rd annual meeting of the American Association for the Study of Liver Diseases (AASLD) in Boston (http://www.aasld.org/lm2012). The study, which was completed in September, investigates the efficacy and safety of the twice-daily dosing (BID) of telaprevir versus dosing every eight hours (q8h) in people chronically infected with genotype-1 hepatitis C virus (HCV) who had not been previously treated.[1]


The results demonstrated that BID dosing of telaprevir 1,125mg in combination with peginterferon alfa and ribavirin (PR), achieved similar cure rates, also known as sustained virological response (SVR12) to q8h dosing of telaprevir 750mg (74.3% versus 72.8%), thereby meeting its primary objective of non-inferiority versus q8h dosing.[1] The safety and tolerability of telaprevir was comparable across dosing arms and consistent with previous studies. The most common adverse events experienced were fatigue, pruritus, anemia, nausea and rash.[

[copyman]

FYI, Me taking the pills with whole milk was not that I took a "risk" or just got lucky. This came from a leading Hepatologist in Boston. I wasn't able to keep the pills down with fat. Taking with milk was an "alternative" that worked.

I'm not suggesting for anyone to take with just milk. But rather then not taking them at all you can drink milk instead.

Actually with this resilient virus I will take some luck as well :-)

[hrsepwrguy]

I guess anything is worth a shot, but if you fail with these drugs, you can't just go back and follow the instructions :) So my advice to all is to follow the instructions.

Have a great day

[willbb]

Wow....40 posts  on what to take Inci with ?

  Possibly try 20 grams of fat for best results. (as per instuctions) as HPG has said...


Will

[hrsepwrguy]

Straight out of janssens incivo booklet

http://www.medhelp.org/user_photos/show/308364?personal_page_id=2257209

http://www.hepcnomads.co.uk/Incivo/Diet_and_Lifestyle_Booklet_incivo.pdf

[BoceprevirGal]

  Just to cover all bases, I ate like a pig.  I always had a yogurt, everytime I took my meds, and a sandwhich, and a glass of milk. Then I would take a walk. I found eating and walking helped to combat any weird, nauseous or dizzy feelings, I was having.
  

[uncledudeness]

yes you do need 20 grams of fat with Incivek....................i'm glad we settled that.....just sayin

[quayle]

I did not say that not to eat fat with it btumy Dr.heptologist,Who has treated thousands and thousandss over ten years,has perscribed thousands of scripts for five years talks with the reps who visit the clinic said it not,nessesary to take 20grms evrytime you take telepravir it just that you take a reasonable amount,so You'll excuse me if I take his word over yours sorry

[quayle]

I know well to take it with food but 15grms of fat is fine I'm not takin any pills during treatment on an empty stomach.

[BoceprevirGal]

  I think all should be fine then, a glass of milk, and a handful of peanuts, would cover it. Nuts and avocados have good fat in them.
  Good luck with your Treatment, and I'll be here, to lend you support/encouragement.
  Have you started yet, and if not, make sure to get a loud alarm, and set it to go off every 8 hrs, for your Incivek dose. I used my cell phone, with a rly annoying jingle. Once my Treatment was over, I couldn't figure out how to get the alarm to stop going off (my husband set it for me) and so I stopped paying my ph bill onthat phone, lol)
  The virus is tricky, so you cant miss even a dose~ good luck

[quayle]

Thanks BoceoravirGal,
                       That's what the doctor and Nurse said to me Just have a tall
glass of full cream milk,or an Avacado they just said when you eat wbefore taking it make sure you have some food woth full fat,not skim or low fat,she said two rich creamy biscuits would do,But I eat too much already so I don't see any problem.