Aa
another crazy idea
im getting close to a decision on this so eventually ill quit bugging yall about it. this new idea is really out of the box. if it starts a riot, its not my fault.
dont try this at home. as an imprisoned hep warrior i certainly cant be held responsible for having rational and logical thoughs can i?
male age 48 1a
peg 120 rib 1000 slated for 48, must stretch to 72, this is my first round
stage 3/4 begining cirrhosis
tx well tolerated, no rescue needed
vl 1,630,000 iu pre
vl 1280 iu 9 weeks over 3 log
vl 80 iu 18 weeks less than 2 log
vl UND 22 weeks (a projection, not realized yet)
what if i go to week 36 and stop all meds. i then check viral loads every week for around 4 weeks. if i stay at UND, i take this aa a good sign and finish the other 36 months. otherwise, if the viremia comes right back, i was probably barking up an empty tree anyway. i do need yalls input on this. this may be a stupid stunt that sabotages all the work i have done. although no one can argue that my performance is not what i wanted it to be, i am doubly vexed to have stare down another 52 weeks. if i dont get svr out of this round my liver needed to restabilze anyway and this part of the game is successful for me if i quit soon. another 52 weeks of 30% - 50% chance (my nonscientific guess at odds) is not so appealling.
dont try this at home. as an imprisoned hep warrior i certainly cant be held responsible for having rational and logical thoughs can i?
male age 48 1a
peg 120 rib 1000 slated for 48, must stretch to 72, this is my first round
stage 3/4 begining cirrhosis
tx well tolerated, no rescue needed
vl 1,630,000 iu pre
vl 1280 iu 9 weeks over 3 log
vl 80 iu 18 weeks less than 2 log
vl UND 22 weeks (a projection, not realized yet)
what if i go to week 36 and stop all meds. i then check viral loads every week for around 4 weeks. if i stay at UND, i take this aa a good sign and finish the other 36 months. otherwise, if the viremia comes right back, i was probably barking up an empty tree anyway. i do need yalls input on this. this may be a stupid stunt that sabotages all the work i have done. although no one can argue that my performance is not what i wanted it to be, i am doubly vexed to have stare down another 52 weeks. if i dont get svr out of this round my liver needed to restabilze anyway and this part of the game is successful for me if i quit soon. another 52 weeks of 30% - 50% chance (my nonscientific guess at odds) is not so appealling.
It's so crazy that you might as well stop at week 22 when you get UND.
Remember - big giant tremendous difference between UND and SVR.
You is crazy!
Remember - big giant tremendous difference between UND and SVR.
You is crazy!
Cruel: what if i go to week 36 and stop all meds. i then check viral loads every week for around 4 weeks. if i stay at UND, i take this aa a good sign and finish the other 36 months. otherwise, if the viremia comes right back, i was probably barking up an empty tree anyway.
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Unfortunatly, it doesn't work that way in most cases. If you stay UND for 4 weeks after treatment then you're probably SVR and no need to do more. Conversly, if the virus comes back, all it tells you is what most doctors would. And that is that 36 weeks of treatment isn't enough for a geno 1 who is still detectible at week 12. 36 weeks of treatment given your slow viral response, as well as your advanced liver damage, is a very big risk that I personally would not take. What you might do, however, is discuss with your doc boosting up the drugs a bit to give you a better chance of better non-detectible by week 24.
All the best,
-- Jim
-------------------------------
Unfortunatly, it doesn't work that way in most cases. If you stay UND for 4 weeks after treatment then you're probably SVR and no need to do more. Conversly, if the virus comes back, all it tells you is what most doctors would. And that is that 36 weeks of treatment isn't enough for a geno 1 who is still detectible at week 12. 36 weeks of treatment given your slow viral response, as well as your advanced liver damage, is a very big risk that I personally would not take. What you might do, however, is discuss with your doc boosting up the drugs a bit to give you a better chance of better non-detectible by week 24.
All the best,
-- Jim
I vote on the bad idea side. That's a lot of work down the drain if it doesn't work plus you say you are doing well on tx so why risk it? Im in a similar damage situation and from what I've read it's even riskier with more damage to do that. I can understand completing therapy and then doing weekly PCR's if you are planning on restarting if it fails, but I wouldn't do it during the course of therapy with that damage level. You never know though, there is no exact science at work here, you could SVR in spite of stopping sooner rather than later.
Trust me, relapse is a bummer you want to avoid. Plus you could end up doing tx a whole lot longer because of trying that if you relapse.
Trust me, relapse is a bummer you want to avoid. Plus you could end up doing tx a whole lot longer because of trying that if you relapse.
Sounds like a bad idea to me.
One thing I've learned from the past three years of research is that the virus looks for weaknesses to get around. Many people here will say hit it HARD upfront, get UND and if a geno 1 stay the course for a longer tx duration.
I went 32 weeks from 3M VL to like 9,600. I kept telling my bone-head doc to up the INF or change it but by letting the virus press against the medicines it found a way around and broke through. My VL raised while on SOC drugs.
What I'm saying is you may just teach your virus some new tricks and become resistant....then what? Kill it in it's tracks, now.
One thing I've learned from the past three years of research is that the virus looks for weaknesses to get around. Many people here will say hit it HARD upfront, get UND and if a geno 1 stay the course for a longer tx duration.
I went 32 weeks from 3M VL to like 9,600. I kept telling my bone-head doc to up the INF or change it but by letting the virus press against the medicines it found a way around and broke through. My VL raised while on SOC drugs.
What I'm saying is you may just teach your virus some new tricks and become resistant....then what? Kill it in it's tracks, now.
Sounds like a bad idea to me.
One thing I've learned from the past three years of research is that the virus looks for weaknesses to get around. Many people here will say hit it HARD upfront, get UND and if a geno 1 stay the course for a longer tx duration.
I went 32 weeks from 3M VL to like 9,600. I kept telling my bone-head doc to up the INF or change it but by letting the virus press against the medicines it found a way around and broke through. My VL raised while on SOC drugs.
What I'm saying is you may just teach your virus some new tricks and become resistant....then what? Kill it in it's tracks, now.
One thing I've learned from the past three years of research is that the virus looks for weaknesses to get around. Many people here will say hit it HARD upfront, get UND and if a geno 1 stay the course for a longer tx duration.
I went 32 weeks from 3M VL to like 9,600. I kept telling my bone-head doc to up the INF or change it but by letting the virus press against the medicines it found a way around and broke through. My VL raised while on SOC drugs.
What I'm saying is you may just teach your virus some new tricks and become resistant....then what? Kill it in it's tracks, now.
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