Data sets are not available from the two trials, Sofosbuvir/Ledipasvir + or - Ribavirin. ION-1 was only for treatment naive. ION-2 just started in January in treatment experienced patients.
Very few patients are not undetectable by week 4 at the latest assuming adequate dosing . Most are undetectable by weeks 2-3.
There are no "breakthroughs" with Sofosbuvir as with interferon based treatments. Sofosbuvir has high barrier to viral resistance. No S282T resistance mutations have been detected. So patients don't fail during treatment.
So the vast majority people that fail treatment do so AFTER stopping treatment.
The treatment terminology used is based on interferon treatment and does not apply to Sofosbuvir based treatments without peg-interferon.
Being undetectable since week two is an excellent response!
Keep staying compliant by not missing any doses and you should have an excellent chance of SRV.
Look for complete data set from your trial at the following...
* The EASL Meeting this April 24-28 (If data is available then)
* The AASLD meeting in November 1-5 of this year.
* HCV New Drug Research - http://hepatitiscnewdrugs.blogspot.com/
At my last bolod draw (4-5-2013) the doc said 2 out of 100 (in my group) had relapsed. Both had not reached UND by week 4 when on the 12 week study, but had achieved UND by the 12 th week. I am not sure when they tested positive after Tx. probably on the 2 week draw.
i assume they were on the combo pill (sofosbuvir/GS-5885) +- riba?
know anything more? i guess not..wonder if that info is out on the net yet (besides what you've reported)
from all the reading i have done, and confirmed by my study nurse, is that UND by week 4 is more than a benchmark, but an indicator of high chance of success (so far at least) and only 12 week of Tx is necessary, not 24
your a young guy Eki...you've got a lot ahead of you..i am 57 and have lived with this for 3 or 4 decades, depending how and when i contracted HCV..if it were not for good family genes, i doubt i would have survived this long.
it will be icing on the cake if this works. good luck to us all!
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