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Marijuana Increases Risk of Hepatitis C-Related Liver Damage
02/03/2008
BETHESDA, Md. – Patients with chronic hepatitis C virus (HCV) infection should not use marijuana (cannabis) daily, according to a study published in Clinical Gastroenterology and Hepatology, the official journal of the American Gastroenterological Association (AGA) Institute. Researchers found that HCV patients who used cannabis daily were at significantly higher risk of moderate to severe liver fibrosis, or tissue scarring. Additionally, patients with moderate to heavy alcohol use combined with regular cannabis use experienced an even greater risk of liver fibrosis. The recommendation to avoid cannabis is especially important in patients who are coinfected with HCV/HIV, since the progression of fibrosis is already greater in these patients.
"Hepatitis C is a major public health concern and the number of patients developing complications of chronic disease is on the rise," according to Norah Terrault, MD, MPH, from the University of California, San Francisco, and lead investigator of the study. "It is essential that we identify risk factors that can be modified to prevent and/or lessen the progression of HCV to fibrosis, cirrhosis and even liver cancer. These complications of chronic HCV infection will significantly contribute to the overall burden of liver disease in the U.S. and will continue to increase in the next decade."
This is the first study that evaluates the relationship between alcohol and cannabis use in patients with HCV and those coinfected with HCV/HIV. It is of great importance to disease management that physicians understand the factors influencing HCV disease severity, especially those that are potentially modifiable. The use and abuse of both alcohol and marijuana together is not an uncommon behavior. Also, individuals who are moderate and heavy users of alcohol may use cannabis as a substitute to reduce their alcohol intake, especially after receiving a diagnosis like HCV, which affects their liver.
Researchers found a significant association between daily versus non-daily cannabis use and moderate to severe fibrosis when reviewing this factor alone. Other factors contributing to increased fibrosis included age at enrollment, lifetime duration of alcohol use, lifetime duration of moderate to heavy alcohol use and necroinflammatory score (stage of fibrosis). In reviewing combined factors, there was a strong (nearly seven-fold higher risk) and independent relationship between daily cannabis use and moderate to severe fibrosis. Gender, race, body mass index, HCV viral load and genotype, HIV coinfection, source of HCV infection, and biopsy length were not significantly associated with moderate to severe fibrosis.
Of the 328 patients screened for the study, 204 patients were included in the analysis. The baseline characteristics of those included in the study were similar to those excluded with the exception of daily cannabis use (13.7 percent of those studied used cannabis daily versus 6.45 percent of those not included). Patients who used cannabis daily had a significantly lower body mass index than non-daily users (25.2 versus 26.4), were more likely to be using medically prescribed cannabis (57.1 percent versus 8.79 percent), and more likely to have HIV coinfection (39.3 percent versus 18.2 percent).
The prevalence of cannabis use amongst adults in the U.S. is estimated to be almost 4 percent. Regular use has increased in certain population subgroups, including those aged 18 to 29.
Source: American Gastroenterological Association
i am a former user myself and have not abused any drugs for 15 years. i am a recovering addict and choose not to use anymore. thats me i cant speak for anyone else. i look at it this way the drugs we put into our bodies to tx hepc are dangerous to our bodies and if pot makes it more easier for someone to get thru then more power to that person. the drugs we use to kill the hepc virus are a regulated drug just as marijuana is as is morphine, codene, as is various other drugs, and all are used for some type of tx.
for me i chose not to do anything that would cause my tx to fail. i asked my doc about pot and he said for me to get the best results from tx would be not to do anything that could jepordize my chances of killing the hepc virus. to each person his own and his alone for no one lives there life thru anyone else but themselves. you will not be judged by me and i am sure by any in this group. i pray you make it thru this journey with strength and for a total recovery.
Nothing that had the slightest chance of making my liver 'unhappy' passed my lips. I won't even take Tylenol.
David
God Bless
I know of some who have used it and others who haven't and some have achieved SVR while others didn't.
My heptalogist said if it helped with the side effects of tx, it was okay with him. He is a reknown researcher and wouldn't okay it if he thought it'd affect my tx negatively. He did say to use as little as needed.
I'm with you.
so for starters, if you quit something that causes 10 times more fibrosis, why would you want to then start including something that causes SEVEN times more fibrosis??
not much of a trade off.
now, if you were in end stage disease, and needed morphine for the pain, at some point all would agree, to heck with the fibrosis the patient has to be made comfortable enough not to expire in total agony...
but we are not there yet by a long shot.
so truth to be told, if I was your doctor, and I'm going to just shoot from the hip here, you would be far less likely to get me to advocate for you when it came to a liver transplant.
In fact for some the sriteria is NO recreational drug use to even be considered.
It sounds like you know enough about the disease to know the next phase is transplant....so since only half the people who need a liver will get one...which side of the equation do you want to be on.
It is true our age and other health conditions play a part in who will get a liver, and who won't...but truth is...there just are not enough livers to go around.
Do you think any doctor able to reason would choose to give a new liver to someone who had been hastening their own demise by continuing to use alcohol or pot knowing it's effect on their disease?? I do not think many would.
nuf said?????
Perhaps your statement should be prefaced with, this is your opinion only. And you've been asked in the past to supply any supporting evidence or study data of this statement, and have so far failed to do so (although there has been a study suggesting a relationship between pot and fibrosis-you are apparently the only one who quotes statistics) ..so basically, IMO your statement carrys no weight. But the invitation is still open...pro
enough, we've been through this a hundred times before, and if anyone is interested they can use the medhelp search feature..
patty1957
" I'm the one that's gotta die, when it's time for me to die, so let me live my life the way I want to"
Jimi Hendrix
Member Comments are provided by individuals and reflect their personal opinions only.
MH, (little grey box, upper left)
Doctors (who have actually been to medical school) do not take this position vis a vis marijuana. I have found it very helpful during tx (used as needed for sx) and previously during cancer chemo. If it gets you through the treatment and you cannot tolerate it otherwise, its a real godsend.
Good luck.
jd
If you were stage 1 or 2 I'd say don't sweat an occassional smoke but at stage 4? You gotta be crazy to think about it.
Sorry, I know that's not the answer you are hoping for but treatment is long and hard and to do it for nothing? Shoot - go for the SVR and forget everything else.
From the National Institute on Drug Abuse http://www.****.html
here's a snippet....
Effects on the Brain
The short-term effects of marijuana can include problems with memory and learning; distorted perception; difficulty in thinking and problem solving; loss of coordination; and increased heart rate.
Effects on the Heart
One study has indicated that an abuser's risk of heart attack more than quadruples in the first hour after smoking marijuana. The researchers suggest that such an effect might occur from marijuana's effects on blood pressure and heart rate and reduced oxygen-carrying capacity of blood.
Effects on the Lungs
Marijuana abuse also has the potential to promote cancer of the lungs and other parts of the respiratory tract because it contains irritants and carcinogens. In fact, marijuana smoke contains 50 to 70 percent more carcinogenic hydrocarbons than does tobacco smoke. It also induces high levels of an enzyme that converts certain hydrocarbons into their carcinogenic form—levels that may accelerate the changes that ultimately produce malignant cells.
mmmmmm... sign me up!
If you don't like that source, try any of the 300 plus thousand sites you get when googling adverse effects marijuana.
I'm not being judgemental here. I smoked pot off and on for 20+ years and the only thing I got was high. The only thing it "relieved" for me was the sting of reality. It relieved me of a whole lot of memories as well. Oh yeah, and cash. I probably aquired HCV while loaded.
It is a personal choice patti57. Nobody here knows if it is, or is not, going to do you harm.
What many here WILL ask you though is, why take the chance?
Here are a couple snipetts (between the lines) from a site touting the BENEFITS of mj use.
http://www.****.com
Cancer
Smoking marijuana has the potential to cause both bronchitis and cancer of the lungs, throat, and neck, but this is generally no different than inhaling any other burnt carbon-containing matter since they all increase the number of lesions (and therefore possible infections) in your airways.
Because smoked marijuana contains a variety of combustion compounds, it can damage the lungs and possibly the immune system. Several health committees recommended the development of an inhalation device that delivers pure THC -- the active ingredient in marijuana -- to the lungs. Such a device has not yet been created.
Smoking marijuana is effective in lowering pressure inside the eyeballs of some patients with glaucoma. A word of caution, however: the drug also drops blood pressure, and this could compromise blood flow to the optic nerve and damage vision.
(Before starting tx, I had to get the OK from an Opthamologist, showing that my retinas were strong enough for interferon.)
You can find any answer you want on this subject, and in the end you'll do as you wish.
I wish you the very best of health.
David
if you asked after I had left a post, and moved on, my apology.
second, glad folks read my posts, but did you check out Clipped Wings post above mine? See that was really pretty!!!!!!!
why would I have provided the study when someone above me just had?
so to recap >>>>>In reviewing combined factors, there was a strong (nearly seven-fold higher risk) and independent relationship between daily cannabis use and moderate to severe fibrosis. ........see study above.
and David then added another below, thank you David.
the case now rests.
sorry if this issue bothers some, but search pub med for fibrosis and marijuana HCV and see what you get. If you could prove otherwise....why didn't you?
OK, this is much I will grant you, the amount of excess fibrosis formed by the biochemical changes to the liver in the presence of cannibanol or alcohol are effected by the concentrations, and whether every study checked every concentration I do not know.
For instance, was alcohol damage calibrated and measured for grain alcohol, and did that differ from other sources?
Bottom line is the "averages" quoted in the study are a pretty good indicator that in the presence of the HCV virus anyone consumming those items will be making a signifigant contribution to their own liver failure that those not so inclined are being spared.
So unless those saying I'm wrong would like to find some research that contradicts what's just been said and the research in this thread, .......
I'll turn it arund and say the burden of proof that I'm wrong is on you all to prove.
meanwhile if Patti listens to me, she will suffer no ill effects, but if you are wrong....well serve her up with fava beans!!
so, sorry Patti if I didn't say it sweet enough....but I'm trying to save you from the misery and pain that comes with a failing liver....and it ain't pretty,
so hopefully strong words work best here.
my best to you all....maryB
the difference is, some fat in the diet will not keep one off a transplant list.
In our town, can not speak for elsewhere, any use of canibanol will keep you off of a transplant list. Most here know that there is difficulty even getting onto treatment drugs if known to be using.....and screens are run on those who are suspected of having issues BECAUSE the tx ITSELF can and DOES sometimes itself damage the liver and can push people into autoimmune hep to go with their hep c.
anyone encouraging others to smoke anything is doing that person no favors.
Insanity is defined as doing the same things over and over again expecting different results!
i hope you dont use while getting tx. but it is your decision.
here in kansas city a man who had a liver transplant was just arrested for his fourth dui.
i guess his defense will be is they gave him a liver so i guess that means it is ok to drink i can just get another one! ( INSANITY ).
I'll turn it arund and say the burden of proof that I'm wrong is on you all to prove...â€
~~~~~~~~~~~~
You are attempting to employ at least two forms of fallacious argument:
Argumentum ad ignorantiam
Argumentum ad ignorantiam means "argument from ignorance." If a writer is trying to argue that something must be or might be real simply because there is no evidence to the contrary, then the writer is using argumentum ad ignorantiam. This fallacy asserts the truthfulness of a proposition simply on the basis that there is no evidence to the contrary:
"Of course UFOs are real. Nobody can prove otherwise."
"Ghosts and other psychic phenomena might very well be real. No one yet has shown any proof that there is no after-life."--
And,
Shifting the burden of proof
Writers always have the burden of proof for validating any assertion or proposition they make. Shifting the burden of proof, a special case of argumentum ad ignorantiam, means putting the burden of proof on the anyone who denies or questions the assertion being made. Like argumentum ad ignorantiam, this fallacy rests on the assumption that something is true unless proven otherwise.
http****
Bill
http://papyr.com/hypertextbooks/comp1/logic.htm
how does me not posting it TWICE prove me ignorant?
if you read this study, in this thread, you will see that apart from the influence of age, NASH or other mitigating conditions the conclusion was fibrosis, OR SCAR tissue to be abslutely clear, formed at a rate seven times faster in the presense of the active agents in cannabis.
after you read the piece maybe you should write the researchers and question their method and report back to us how they culd be so wrong. Or site some article from High Times Magazine, heck if I know.
Me I'll stick with the science,
this and other studies have been posted in here before....I can't help it if people are too busy rolling one to read through a thread without knee jerk reactions.
my choice, and the ne I recommend t those who want to live is not to take things that are knwn to further harm their liver. You all can make up your own minds. We are all entitled to make that choice and some of do choose ignorance, yu are oh so right there.
here AGAIN in that study
by ClippedWings
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ClippedWings
, Mar 08, 2008 07:26PM
To: Patti
You'll find much debate on this issue here and elsewhere. My doctors have all told me that maijuana is bad for the liver and will increase inflamation (inflammation). Not all docs agree. Plenty of folks on this site will tell you that they wouldn't have made it through treatment without a little pot to help ease side effects. I also have cirrhosis and I would recommend that you read up on cirrhosis- it's a real potential killer. You need to do everything in your power to try to retain all the life you can out of your liver and not engage in any activity that would add stress to your already severely damaged organ. Whatever you decide, best of luck to you. Here is a recent study I found:
Marijuana Increases Risk of Hepatitis C-Related Liver Damage
02/03/2008
BETHESDA, Md. – Patients with chronic hepatitis C virus (HCV) infection should not use marijuana (cannabis) daily, according to a study published in Clinical Gastroenterology and Hepatology, the official journal of the American Gastroenterological Association (AGA) Institute. Researchers found that HCV patients who used cannabis daily were at significantly higher risk of moderate to severe liver fibrosis, or tissue scarring. Additionally, patients with moderate to heavy alcohol use combined with regular cannabis use experienced an even greater risk of liver fibrosis. The recommendation to avoid cannabis is especially important in patients who are coinfected with HCV/HIV, since the progression of fibrosis is already greater in these patients.
"Hepatitis C is a major public health concern and the number of patients developing complications of chronic disease is on the rise," according to Norah Terrault, MD, MPH, from the University of California, San Francisco, and lead investigator of the study. "It is essential that we identify risk factors that can be modified to prevent and/or lessen the progression of HCV to fibrosis, cirrhosis and even liver cancer. These complications of chronic HCV infection will significantly contribute to the overall burden of liver disease in the U.S. and will continue to increase in the next decade."
This is the first study that evaluates the relationship between alcohol and cannabis use in patients with HCV and those coinfected with HCV/HIV. It is of great importance to disease management that physicians understand the factors influencing HCV disease severity, especially those that are potentially modifiable. The use and abuse of both alcohol and marijuana together is not an uncommon behavior. Also, individuals who are moderate and heavy users of alcohol may use cannabis as a substitute to reduce their alcohol intake, especially after receiving a diagnosis like HCV, which affects their liver.
Researchers found a significant association between daily versus non-daily cannabis use and moderate to severe fibrosis when reviewing this factor alone. Other factors contributing to increased fibrosis included age at enrollment, lifetime duration of alcohol use, lifetime duration of moderate to heavy alcohol use and necroinflammatory score (stage of fibrosis). In reviewing combined factors, there was a strong (nearly seven-fold higher risk) and independent relationship between daily cannabis use and moderate to severe fibrosis. Gender, race, body mass index, HCV viral load and genotype, HIV coinfection, source of HCV infection, and biopsy length were not significantly associated with moderate to severe fibrosis.
Of the 328 patients screened for the study, 204 patients were included in the analysis. The baseline characteristics of those included in the study were similar to those excluded with the exception of daily cannabis use (13.7 percent of those studied used cannabis daily versus 6.45 percent of those not included). Patients who used cannabis daily had a significantly lower body mass index than non-daily users (25.2 versus 26.4), were more likely to be using medically prescribed cannabis (57.1 percent versus 8.79 percent), and more likely to have HIV coinfection (39.3 percent versus 18.2 percent).
The prevalence of cannabis use amongst adults in the U.S. is estimated to be almost 4 percent. Regular use has increased in certain population subgroups, including those aged 18 to 29.
Source: American Gastroenterological Association
I wasn’t insinuating you are ignorant; that is another issue entirely :o). I was simply trying to point out the fallacy in your argument:
“…So unless those saying I'm wrong would like to find some research that contradicts what's just been said and the research in this thread, .......
I'll turn it arund and say the burden of proof that I'm wrong is on you all to prove…â€
In order to participate in civil debate, it is necessary to follow certain rules and decorum. Again, shifting the burden of proof just doesn’t hold water. Please refer to the following text for reference:
http://papyr.com/hypertextbooks/comp1/logic.htm
Bill
I think humans are incredibly resilient and even if you are one of the people that has it worse then me, with advice, support... you will handle it. The waiting is the worse. It is easy to want to go back to your old ways of making it easier for yourself (a drink or smoke). There are other ways to baby yourself through this if you need it (tylenol, anti depressants. skin lotion, ..) and I would set yourself up with everything people here and your doctor office recommends.
Everyone will tell you the waiting is worse and not smoking or drinking may be easier then you are worried about. Good luck
sorry to hear about your pot bust. you know for a 69 year old pot smoking chick, your mug photo doesn't look half bad
http://seattletimes.nwsource.com/html/localnews/
2004274692_webdawnwells11m.html.
P.S. anytime you feel like ditching gilligan and going down to the lagoon to smoke a J, let me know.
love
eric
Medical Marijuana Improves HCV Treatment Response
Medical cannabis can help people with hepatitis C stay on treatment and achieve better outcomes, according to a study in the October 2006 European Journal of Gastroenterology and Hepatology. Dr. Diana Sylvestre and colleagues studied 71 patients with HCV at OASIS (a substance use clinic in Oakland) who had been on methadone maintenance for at least three months. About one-third used marijuana while undergoing anti-HCV treatment with conventional interferon plus ribavirin. The researchers found that 54% of cannabis users had undetectable HCV six months after completing treatment, compared with 18% of non-users. While the frequency of side effects was similar in both groups, cannabis users were more likely to stay on therapy.
But this doesn’t mean hep C patients should indulge without restraint: in the OASIS study, those who used the largest amounts of cannabis did not show as much benefit as moderate users, and a previous study found that HCV positive people who smoked marijuana every day were more likely to experience rapid liver fibrosis progression. Nevertheless, in an accompanying editorial, a group of hepatitis C experts recommended that while further research is underway, “we advocate that in the interim existing barriers to cannabis use are removed for drug users undergoing HCV treatment.â€
i have occasional stomach issues that i am pretty sure were caused by tx and pot is the only thing that helps it, the fools in this country who think that marijuana has no medical value are very very wrong
He was diagnosed with HCV back in the late 1980's and I understand he had mild liver inflammation and the beginning of "peicemeal necrosis" seen in a biposy in the mid 1990's.
He had second biopsy back about 2000-2001 showed very little change.
His last biopsy showed scores of "1 and 1" for damage to the liver. He doesn't know what it means but the doctor tells him that it is the lowest level of liver damage on the scale (except of course for zero which means no damage at all).
Go figure.
cheese