Aa
eating on triple tx
I am starting my tx soon, I think I read you should eat 20 grams of fat 1 half an hr before meds, if this is right should you also eat 20 grams with riba 30 minutes prior to riba meds also, this is my 2nd time treating do not want to make mistakes if I can help it. Thanks Stalion
Best Answer
Correction: "I also 'take' the Ribavirin with a meal containing 20 grams of fat." (I am still on Ribavirin so past tense is not appropriate. Wishful thinking, lol.)
My understanding is that if you are taking Incivek you take the Incivek within 30 minutes after eating a meal containing 20 grams of fat.
"How should I take INCIVEK?"
"Take INCIVEK exactly as your healthcare provider tells you. Take 2 INCIVEK pills 3 times a day, 7 to 9 hours apart, with food. Eat a meal or snack containing about 20 grams of fat within 30 minutes before you take each dose. Talk to your healthcare provider about examples of food you can eat."
I also took the Ribavirin with a meal containing 20 grams of fat. I read something that said the absortion and serum concentration levels were better if taken with the fat but that was a one dose deal so I don't know how valid it is. The drug info just says take Riba with a substantial meal.
"Effect of Food on Absorption of Ribavirin"
"Bioavailability of a single oral dose of Ribavirin was increased by co-administration with a high-fat meal. The absorption was slowed (Tmax was doubled) and the AUC0-192h and Cmax increased by 42% and 66%, respectively, when Ribavirin tablets were taken with a high-fat meal compared with fasting conditions [see Dosage and Administration (2.1) and Patient Counseling Information (17)]."
http://www.drugs.com/pro/ribavirin.html
Here is a link to a previous thread discussing this issue.
Hope this helps and good luck with your treatment!
"How should I take INCIVEK?"
"Take INCIVEK exactly as your healthcare provider tells you. Take 2 INCIVEK pills 3 times a day, 7 to 9 hours apart, with food. Eat a meal or snack containing about 20 grams of fat within 30 minutes before you take each dose. Talk to your healthcare provider about examples of food you can eat."
I also took the Ribavirin with a meal containing 20 grams of fat. I read something that said the absortion and serum concentration levels were better if taken with the fat but that was a one dose deal so I don't know how valid it is. The drug info just says take Riba with a substantial meal.
"Effect of Food on Absorption of Ribavirin"
"Bioavailability of a single oral dose of Ribavirin was increased by co-administration with a high-fat meal. The absorption was slowed (Tmax was doubled) and the AUC0-192h and Cmax increased by 42% and 66%, respectively, when Ribavirin tablets were taken with a high-fat meal compared with fasting conditions [see Dosage and Administration (2.1) and Patient Counseling Information (17)]."
http://www.drugs.com/pro/ribavirin.html
Here is a link to a previous thread discussing this issue.
Hope this helps and good luck with your treatment!
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The systemic exposure (AUC) to telaprevir was increased by 237% when telaprevir was administered with a standard fat meal (containing 533 kcal and 21 g fat) compared to when telaprevir was administered under fasting conditions. In addition, the type of meal significantly affects exposure to telaprevir. Relative to fasting, when telaprevir was administered with a low-fat meal (249 kcal, 3.6 g fat) and a high-fat meal (928 kcal, 56 g fat), the systemic exposure (AUC) to telaprevir was increased by approximately 117% and 330%, respectively. Doses of INCIVEK were administered within 30 minutes of completing a meal or snack containing approximately 20 grams of fat in the Phase 3 trials. Therefore, INCIVEK should always be taken with food (not low fat).
http://pi.vrtx.com/files/uspi_telaprevir.pdf
Effect of food on absorption of ribavirin:
Both AUC and C-MAX increased by seventy percent when Rebetol Capsules were administered with a high fat meal: (841 kcal, 53.8 g fat, 31.6 g protein, and 57.4 g carbohydrate) in a single-dose pharmacokinetic study
http://www.spfiles.com/pipeg-intron.pdf
If you do the math you will have to eat 26.9 grams of fat for a 35% increase in absorbtion .