Hepatitis C Community
geno 1
About This Community:

This forum is for questions about medical issues and research aspects of Hepatitis C such as, questions about being newly diagnosed, questions about current treatments, information and participation in discussions about research studies and clinical trials related to Hepatitis. If you would like to communicate with other people who have been touched by Hepatitis, please visit our new Hepatitis Social/Living with Hepatitis forum

Font Size:
A
A
A
Background:
Blank
Blank
Blank
Blank Blank

geno 1

Is it very common to be undetectable after 4 weeks with geno 1a?  mine dropped from like 20million to 2 million so will be doing 48 weeks
4 Comments Post a Comment
Blank
766573_tn?1365170066
UND in week 4 (& remaining so in week 12) is called eRVR (Extended Rapid Virological Response)

The Inviek site says in the Advance trial says:

The majority of treatment-naïve patients (58%) and prior relapsers (78% and 76% in the Phase 2 and REALIZE trials, respectively) achieved eRVR (undetectable HCV RNA at Weeks 4 and 12). eRVR is used to determine treatment duration in appropriate patients.

So 42% do not.

In the Illuminate trial 65% achieved eRVR
_____________________


http://www.incivek.com/hcp/extended-rapid-virologic-response-ervr

Hang in there!
You will slay this beast!
Blank
1747881_tn?1358189534
I think she is on victrelis
Blank
1747881_tn?1358189534
In addition, consideration should be given to treating previously untreated patients who are poorly interferon responsive (as determined at TW4) with 4 weeks peginterferon alfa and ribavirin followed by 44 weeks of VICTRELIS 800 mg orally three times daily (every 7 to 9 hours) in combination with peginterferon alfa and ribavirin in order to maximize rates of SVR [see Clinical Studies (14)]

Previously Untreated Subjects In previously untreated subjects evaluated in SPRINT-2, interferon-responsiveness (defined as greater than or equal to 1-log10 decline in viral load at TW4) was predictive of SVR. VICTRELIS-treated subjects who demonstrated interferon responsiveness at TW4 achieved SVR rates of 81% (203/252) in VICTRELIS-RGT arm and 79% (200/254) in VICTRELIS-PR48 arm, compared to 52% (134/260) in subjects treated with PegIntron/REBETOL.  VICTRELIS-treated subjects who demonstrated poor interferon responsiveness (defined as less than 1-log10 decline in viral load at TW4), achieved SVR rates of 28% (27/97) in VICTRELIS-RGT arm and 38% (36/95) in VICTRELIS-PR48 arm, compared to 4% (3/83) in subjects treated with PegIntron/REBETOL.  Subjects with less than a 0.5-log10 decline in viral load at TW4 achieved SVR rates of 28% (13/47) in VICTRELIS-RGT arm and 30% (11/37) in VICTRELIS-PR48 arm, compared to 0% (0/25) in subjects treated with PegIntron/REBETOL. Subjects with less than a 0.5-log10 decline in viral load at TW4 with peginterferon alfa plus ribavirin therapy alone are predicted to have a null response (less than 2-log10 viral load decline at TW12) to peginterferon alfa and ribavirin.

You had a 1 log drop after the 4 week lead in
Blank
766573_tn?1365170066
Oh sorry I get the 48 weeks of treatment with barely a one log drop by the four week point.

I think the point is that in the trials a person did not have to be UND at week 4 only a 1 log drop to still have the better odds

_________________--
The very last sentence in this article says. "Highest SVR rates found in patients treated with boceprevir-based regimen who experienced ≥ 1 log10 decline in HCV RNA after 4-week pegIFN/RBV lead-in, regardless of IL28B genotype.

http://www.clinicaloptions.com/Hepatitis/Conference%20Coverage/Berlin%202011/From%20Podium%20to%20Practice/Capsules/12.aspx?lg=print

_____________________

Hang in there!!!!!
Blank
Post a Comment
To
Blank
Weight Tracker
Weight Tracker
Start Tracking Now
Hepatitis C Community Resources
RSS Expert Activity
469720_tn?1388149949
Blank
Abdominal Aortic Aneurysm-treatable... Blank
Oct 04 by Lee Kirksey, MDBlank
242532_tn?1269553979
Blank
The 3 Essentials to Ending Emotiona...
Sep 18 by Roger Gould, M.D.Blank
242532_tn?1269553979
Blank
Control Emotional Eating with this ...
Sep 04 by Roger Gould, M.D.Blank
Top Hepatitis Answerers
446474_tn?1404424777
Blank
HectorSF
CA
317787_tn?1373214989
Blank
Dee1956
DC
Avatar_f_tn
Blank
patra_
DeLand, FL
Avatar_f_tn
Blank
Livelife777
Avatar_f_tn
Blank
susan400
FL
163305_tn?1333672171
Blank
orphanedhawk
Rural Mural, CA