Hepatitis C Community
grapefruit flavionoids
About This Community:

This forum is for questions about medical issues and research aspects of Hepatitis C such as, questions about being newly diagnosed, questions about current treatments, information and participation in discussions about research studies and clinical trials related to Hepatitis. If you would like to communicate with other people who have been touched by Hepatitis, please visit our new Hepatitis Social/Living with Hepatitis forum

Font Size:
A
A
A
Background:
Blank
Blank
Blank
Blank Blank

grapefruit flavionoids

just read something about  grapefruit flavinoides inhibits hcv.
this interests me and i wonder if anyone else has heard of this??
Related Discussions
14 Comments Post a Comment
Blank
96938_tn?1189803458
Blank
Avatar_m_tn
Most articles I've read on naringenin/grapefruit juice point the research that's been done at the Massachusetts general hospital.  They've discovered it may inhibit viral replication by interfering with secretion of new virus particles from infected cells.  This compound may be able to block the secretion of the hcv virus from infected cells, a process needed to maintain chronic infection.  

Researchers at Shriners Burns Hospital/ Harvard University revealed that naringenin a metabolite of the bioflavonoid naringin gives grapefruit bitter taste, noted that it may help fight the hcv virus.  This possible reduction in viral load by inhibiting viral secretion could allow uninfected cells to regenerate, which could potentially increase overall rate of viral clearance. "  
Blank
29837_tn?1314410659
I drink a glass every single day. Get the Simply Grapefruit brand, which is pretty much juice not juice extract. You can find it at Wal-Mart and most grocery stores. Pucker up...

Magnum
Blank
87972_tn?1322664839
Julie, if you’re going to drink a lot of grapefruit juice and include it with other meds, be sure to discuss it with the doctor. Grapefruit juice can affect how your body metabolizes certain drugs, so clear it with the doc—

Bill
Blank
Avatar_n_tn
I read those articles too. Some of them forget to mention that the level of naringenin concentration needed is impossible to achieve simply by drinking the juice, or even by taking supplements. I've drank grapefruit juice for 3 months, and it made me feel great, full of energy, plus my gallstones stopped bothering me. Yet, as for HCV, my viral load actually grew by the end of the third month. This is when I agreed to start tx. Don't mean to discourage you, but I don't think grapefruit juice is helpful as far as VL reduction concerned.
Blank
Avatar_f_tn
Actually,not on any meds right now.
I have a prescription for priloseck but haven't filled it yet!
well i'm not going to start downing grapefruit ,lol!
there is a local trial i found ,considering trying to get in on it .
just not sure about being a ginnie pig,but on the other hand it's grapefruit whats the worst thing that can happen ?Still need to find out more about it before i make a real decision on it ! IT does seem a little crazy that something like grapefruit may turn into an alternitive to standard tx
                       ty-julie
Blank
Avatar_f_tn
Good link from FlGuy, which led me to this short one from Dr. Dieterich:

http://www.medhelp.org/posts/Hepatitis-C/Treatment-for-Hep-C--Grapefruit-Juice/show/542498

Blank
Avatar_f_tn
very interesting
         ty-julie
Blank
1391312_tn?1385483252
Hey Julie,
If your taking Prilosec for acid control, the last thing you want to do is put more acid in your tummy.  Drink cococut water, no acid & good for you ;)
Blank
Avatar_n_tn
From
http://www.hepatitis-central.com/mt/archives/2008/02/what_you_need_t.html

Grapefruit Warning

While just a few of grapefruit’s many health benefits are described above, there is a bittersweet side to this popular fruit. Grapefruit and its juice can be dangerous to people who take certain medications.

Amy Karch, RN, MS, of the School of Nursing at the University of Rochester Medical Center, an expert on drug interactions, explains that grapefruit juice is one of the foods most likely to cause problems with medications. The cytochrome P-450 3A4 enzyme breaks down grapefruit juice into useful components for the body, just like it breaks down dozens of medications. Grapefruit juice can block this enzyme, making it easier for medications metabolized by the same pathway to pass rapidly from the digestive system to the bloodstream. The result is blood levels of the drug rising faster and higher than normal. In some cases the abnormally high medication levels can be dangerous.

Consisting of more than 50 medications, interactions with grapefruit juice are well-known among researchers and clearly documented on warning labels. However, people commonly fail to comprehensively read the warning labels about drug-food interactions. In addition, it doesn’t take much grapefruit juice to boost the levels of drugs that are susceptible. A single glass can produce a 47 percent reduction of the intestinal enzyme that regulates absorption. Since the effect of grapefruit juice wears off slowly, a third of its impact is still evident after 24 hours.

While this list is not complete, some of the drugs interacting with grapefruit include:

· Anxiety: Xanax, Buspar, Versed, Halcion
· Depression: Luvox, Zoloft
· Allergies: Allegra
· Abnormal heart rhythm: Cordarone, quinidine
· Heart disease/stroke/blood clots: Coumadin
· Epilepsy: Tegretol
· Cancer: Cyclophosphamide, etoposide, ifosfamide,
tamoxifen, vinblastine, vincristine
· Cough: Dextromethorphan (found in many over-the-counter cold
medicines)
· HIV: Agenerase, Crixivan, Viracept, Norvir, Fortovase
· Prostate enlargement: Proscar
· Heart disease/High blood pressure: Coreg, Cardizem, Plendil, Cardene, Adalat, Procardia, Nimotop, Sular, Covera, Calan, Verelan
· Erectile dysfunction: Viagra, Cialis
· Asthma/Emphysema: Theophylline
· High cholesterol: Lipitor, Lescol, Mevacor, Zocor
· Pain: Alfenta, Duragesic, Actiq, Sufenta
· Infection: Biaxin, Sporanox, erythromycin, troleandomycin
Blank
96938_tn?1189803458
I was somewhat surprised to find that it's not blood-sugar friendly either.  After thinking about it more - it's not so surprising.  For example, a recommended response to LOW blood-sugar events is to drink orange juice.  So, even though I like grapefruit juice I avoid it like grapes, and watermelon. Plus, the medication aspect.....
Blank
Avatar_f_tn
Wow diden't know one little fruit can cause so much problems w/so many meds ! I've only heard off it reacting w/ heart meds,,as for the trial i was thinking about I found out it's a stage one and i'm not going to  be part off it ,maybe if I was  single w/ no kiddies I would consider a stage one trial,IN DESPERATION of trying to feel proactive about my disease I'm not sure grapefruit is the answer .thank you all for your informative answers
                                                     -julie:)
Blank
Avatar_f_tn
Since I'm not taking any of the above mentioned medications, I plan to add one grapefruit a day.  
Blank
96938_tn?1189803458
If you are going to eat grapefruit, please make sure it's from Florida.  We need the help.
Blank
Post a Comment
To
Blank
Weight Tracker
Weight Tracker
Start Tracking Now
Hepatitis C Community Resources
RSS Expert Activity
242532_tn?1269553979
Blank
The 3 Essentials to Ending Emotiona...
Sep 18 by Roger Gould, M.D.Blank
242532_tn?1269553979
Blank
Control Emotional Eating with this ...
Sep 04 by Roger Gould, M.D.Blank
242532_tn?1269553979
Blank
Emotional Eating Control: How to St...
Aug 28 by Roger Gould, M.D.Blank
Top Hepatitis Answerers
683231_tn?1408489117
Blank
flyinlynn
Auburn, WA
1815939_tn?1377995399
Blank
pooh55811
446474_tn?1404424777
Blank
HectorSF
CA
Avatar_m_tn
Blank
can-do-man
IN
Avatar_f_tn
Blank
nan535
Brooklyn, NY
766573_tn?1365170066
Blank
Idyllic