The hep C treatment has been tough on my tummy. No telling how yours will react. If your stomach has not yet recovered from the antibiotic regimen and the helicobacter pylori, you might wait a few weeks before starting tx for HCV.
Ask your doctor to test you to make sure the H.Pylori is gone. Having H.Pylori lowers Hep C treatment success.
Effect Of Helicobacter Pylori Infection on Hepatitis C Virus Infection.
H.T. El-Zimaity, B. Yoffe, T. Tabassi, B. Hollinger, S.A. Abudayyeh, Z.Z. Nurgalieva, F. Hammoud, B.S. Anand.
Hepatitis C virus (HCV) is a major cause of chronic liver disease, cirrhosis and hepatocellular carcinoma (HCC). It has been observed that African Americans (AA) have a higher infection rate, an inferior response to anti-viral treatment, and are more likely to develop HCC compared to Whites. It is unclear why these ethnic differences occur. A possible explanation is the confounding effect of concurrent infections such as H. pylori (HP) is more prevalent in AA. HP might influences HCV infection by altering the host immune response. Aim: To compare HCV viral load and treatment response in HP positive vs. HP negative patients.
HCV was confirmed by positive HCV-RNA by PCR. HCV viral load was determined at baseline (prior to treatment), after 24 and 48 weeks of treatment, and at 6 month after stopping anti-viral therapy. Sustained virology response (SVR) was defined as negative HCV-PCR 6 months post therapy. Patients were treated with interferon alone or interferon and ribavirin combination therapy. HP status was assessed by serology (HM-CAP; Enteric Products Inc, Stony Brook, NY).
107 patients with HCV infection were included (42 received monotherapy and 65 combination therapy). 42 (39%) were HP antibody positive. The SVR rate was lower among HP positive patients compared to HP negative patients (19% vs. 43%) (p = 0.01). By ordered logistic regression analysis, other factors associated with a lower SVR rate were genotype 1 and being African American. The baseline viral load was also lower in HP negative patients compared to HP positive patients (p<0.001). After treatment, the mean viral load in the non-responder patients (27 HP negative and 32 HP positive) was higher in HP positive patients (2.32 x 106 + 3.2 vs. 1.51 x 106 + 4.8 copies) (p = 0.056).
HP (H.Pylori) infection is associated with significantly lower sustained virologic response rate and a higher HCV viral load compared to patients without HP infection. The lower SVR rate in AA may be explained by the higher prevalence of H. pylori infection. Eradication of H. pylori infection might result in a significant improvement in the outcome of HCV treatment.
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