Aa
A
A
Close
917763 tn?1311632496
helicobacter pylori and hep c treatments
Today is my last day of treatment for Helicobacter pylori. I will be starting treatment for hep c Wednesday.  Will this make me more nauasa?
Cancel
3 Answers
Page 1 of 1
9648 tn?1290094807
The hep C treatment has been tough on my tummy. No telling how yours will react. If your stomach has not yet recovered from the antibiotic regimen and the helicobacter pylori, you might wait a few weeks before starting tx for HCV.
Comment
Cancel
Comment
Avatar universal
Comment
Comment
Submit Comment
568322 tn?1370169040
Ask your doctor to test you to make sure the H.Pylori is gone.  Having H.Pylori lowers Hep C treatment success.

Co



Effect Of Helicobacter Pylori Infection on Hepatitis C Virus Infection.

H.T. El-Zimaity, B. Yoffe, T. Tabassi, B. Hollinger, S.A. Abudayyeh, Z.Z. Nurgalieva, F. Hammoud, B.S. Anand.

Background

Hepatitis C virus (HCV) is a major cause of chronic liver disease, cirrhosis and hepatocellular carcinoma (HCC).  It has been observed that African Americans (AA) have a higher infection rate, an inferior response to anti-viral treatment, and are more likely to develop HCC compared to Whites.  It is unclear why these ethnic differences occur. A possible explanation is the confounding effect of concurrent infections such as H. pylori (HP) is more prevalent in AA.  HP might influences HCV infection by altering the host immune response. Aim: To compare HCV viral load and treatment response in HP positive vs. HP negative patients.  

Methods

HCV was confirmed by positive HCV-RNA by PCR.  HCV viral load was determined at baseline (prior to treatment), after 24 and 48 weeks of treatment, and at 6 month after stopping anti-viral therapy. Sustained virology response (SVR) was defined as negative HCV-PCR 6 months post therapy. Patients were treated with interferon alone or interferon and ribavirin combination therapy.  HP status was assessed by serology (HM-CAP; Enteric Products Inc, Stony Brook, NY).  

Results

107 patients with HCV infection were included (42 received monotherapy and 65 combination therapy). 42 (39%) were HP antibody positive.  The SVR rate was lower among HP positive patients compared to HP negative patients (19% vs. 43%) (p = 0.01).  By ordered logistic regression analysis, other factors associated with a lower SVR rate were genotype 1 and being African American. The baseline viral load was also lower in HP negative patients compared to HP positive patients (p<0.001).  After treatment, the mean viral load in the non-responder patients (27 HP negative and 32 HP positive) was higher in HP positive patients (2.32 x 106 + 3.2 vs. 1.51 x 106 + 4.8 copies) (p = 0.056).

Conclusion

HP (H.Pylori) infection is associated with significantly lower sustained virologic response rate and a higher HCV viral load compared to patients without HP infection.  The lower SVR rate in AA may be explained by the higher prevalence of H. pylori infection.  Eradication of H. pylori infection might result in a significant improvement in the outcome of HCV treatment.

http://www.hcvadvocate.org/news/reports/DDW_2005/May%2017%20HCV.htm#May17_2
Comment
Cancel
Comment
Avatar universal
Comment
Comment
Submit Comment
917763 tn?1311632496
Thanks for the info I'm beening treated for both by the same Dr. So hopefully he will take that all in concerderation.

Comment
Cancel
Comment
Avatar universal
Comment
Comment
Submit Comment
Your Answer
Avatar universal
Answer
Know how to answer? Tap here to leave your answer...
Answer
Submit Answer
A
A
Recent Activity
317787 tn?1472134636
Blank
Dee1956 Meegy has 76 days, so proud... Comment
46 mins ago
317787 tn?1472134636
Blank
Dee1956 commented on meegWpaw's status
3 hrs ago
317787 tn?1472134636
Blank
Dee1956 commented on sue4hula's status
4 hrs ago
Blank
Weight Tracker
Track your weight over time
Start Tracking Now
Top Hepatitis Answerers
317787 tn?1472134636
Blank
DC
163305 tn?1333672171
Blank
Rural Mural, CA
446474 tn?1446351282
Blank
San Francisco, CA
Avatar universal
Blank
1747881 tn?1358189534
Blank
Greeley, CO
2059648 tn?1439770265
Blank
Hepatitis C Community Resources