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hep-c

i am currently taking suboxeon for my back pain  , in about a month im going to start the pegasys hep c treatment . my question is can i take these together .
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87972_tn?1322664839
To my knowledge there aren’t any issues with concurrent use of suboxone and IFN therapy. Good luck with your treatment,

--Bill
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Avatar_f_tn
thank you ive been a little worried about  taking them together, im sure before im done ill have more concerns its nice to get oppinions from other . thank you agian
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Avatar_m_tn
I'm now on week 22 of my pegasys/riba therapy and been taking suboxone ever since and never had any problems. I would check with my physician however just to make sure
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568322_tn?1370169040
I disagree.

Suboxone contains four parts buprenorphine and one part naloxone.  And naloxone works by blocking opioid receptors ...just like naltrexone.

And it is a well known fact that the use of naltrexone is contraindicated with interferon because it COUNTERS some of the effects of interferon.

For example....Naloxone suppresses the rising phase of fever induced by interferon-alpha.  And fever during treatment is a good thing.  

I would do some more research if I was you.  Because although suboxone may be considered safe, it may also counter the effects from the med you want working at its best.  Naloxone can also increase liver enzymes and it can interfere with Telaprevir and Boceprevir if you're planning to use triple therapy.

Co
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Avatar_f_tn
I'm currently taking pegasys injection, ribaviron, and incivek (the triple treatment) and am also taking subutex not suboxone. I need to know ASAP if this is okay to take can anyone please give me some basic info or an answer? I'm so desperately concerned about it as well as my own well being
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766573_tn?1365170066
I have seen this question asked before.I can cut and paste a few studies but truly you ought to collaborate with the doctor who prescribed the Incivek. That person needs to be aware of all meds you are taking.
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Subutex is buprenorphine. Here is an FDA article that product labeling revisions for Incivek (Teleprevir)

It says "...no dose adjustment is needed for Incivek when given with either raltegravir or buprenorphine."
http://www.fda.gov/ForConsumers/ByAudience/ForPatientAdvocates/ucm309863.htm
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Here is another:
The Effect of Telaprevir on the Pharmacokinetics of Buprenorphine in Volunteers on Stable Buprenorphine/Naloxone Maintenance Therapy

Co-administration of telaprevir did not increase withdrawal symptom frequency and there were no serious adverse events reported during or after completion of telaprevir co-administration.

===>>>Results suggest dose adjustment may not be necessary when telaprevir and buprenorphine/naloxone are co-administered.
http://aac.asm.org/content/early/2012/05/02/AAC.00077-12.abstract
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Here is a table that shows (possible) drug interactions with Telaprevir/Buprenorphine

Telaprevir Metabolic Substrate: CYP 3A4 (major) into inactive and active metabolite (30 times less active than telaprevir)

Metabolic Inhibitor: CYP 3A4 - Substrate and inhibitor of P-gp (intestinal rather than systemic and would be saturable)

Buprenorphine Metabolic Substrate: CYP 3A4>2C8 (norbuprenorphine active metabolite), UGT 1A1 and other UGT (norbuprenorphine combination and its metabolites)

===>>>Significance: Non clinically significant interaction.

http://www.hivmedicationguide.com/details.asp?ID=9363&name=Telaprevir%20/%20Buprenorphine
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