high ggpt

what is the cure for high ggpt?

[Boobert]

Do you drink alcohol?

[SusieS2010]

It depends on what is causing the elevation. If it is alcohol or drugs, stopping will likely cure it. If it is hep C or one of the other hepatitis viruses, treating the virus successfully will cure it.

[IAmTheWalrus]

High ggt is not a disease, just an indication that something is amiss with the liver, specifically. It is often used to confirm that high ALT or AST numbers are due to liver inflamation (inflammation). These can be elevated from other sources, but the ggt is more specific to the liver.

Ditto what SusieS2010 says.

[CoWriter]

In Hep C patients an elevated GGTP is often associated with having insulin resistance.

Co


Dig Liver Dis. 2009 Aug

Elevation of serum gamma-glutamyltranspeptidase (GGTP) activity is frequent in chronic hepatitis C, and is associated with insulin resistance.

Benini F, Pigozzi MG, Pozzi A, Bercich L, Reggiani A, Quattrocchi D, Distefano L, Donati P, Cesana BM, Lanzini A.

BACKGROUND AND AIMS: Serum gamma-glutamyltranspeptidase level is often increased in patients with chronic hepatitis C, and we aimed to identify factors associated with this phenomenon in patients completely abstinent from alcohol (teetotaller). PATIENTS AND METHODS: 71 teetotaller patients have been identified by personal history, questioning of relatives, CAGE questionnaire administration and unscheduled alcoholemia measurements. RESULTS: 39 patients (55%) had elevated (>50IU/L) gamma-glutamyltranspeptidase level. Body mass index, insulin and C-peptide level, insulin resistance, piecemeal necrosis score > or =3, fibrosis score > or =2 and steatosis score > or =1 were significantly higher in these patients than in those (n=32) with normal gamma-glutamyltranspeptidase. At multiple linear regression analysis gamma-glutamyltranspeptidase level was associated with C-peptide level, insulin resistance and histopathologic grading. At multiple logistic regression analysis, C-peptide level (OR=2.13) and piecemeal necrosis score > or =3 (OR=4.59) were the only factors independently associated with elevated gamma-glutamyltranspeptidase. Sustained virological response during pegylated interferon plus ribavirine treatment was achieved by 97% and 49% patients with normal and elevated gamma-glutamyltranspeptidase, respectively (p=0.0001).

CONCLUSION: Serum gamma-glutamyltranspeptidase level is often elevated in chronic hepatitis C and is associated with metabolic and inflammatory factors; this phenomenon may contribute to explain and to predict resistance to treatment in this subgroup of patients.

[IAmTheWalrus]

CoWriter,

I did not know that. That is really good information and explains neatly my personal experience. It is one more factor that indicates that I have insulin resistance. I now think that is the single most important factor in my relapse after 84 weeks of TX.

Thank you,
Brent