Hepatitis C Community
how long does pegintron stay in the body?
About This Community:

This forum is for questions about medical issues and research aspects of Hepatitis C such as, questions about being newly diagnosed, questions about current treatments, information and participation in discussions about research studies and clinical trials related to Hepatitis. If you would like to communicate with other people who have been touched by Hepatitis, please visit our new Hepatitis Social/Living with Hepatitis forum

Font Size:
A
A
A
Background:
Blank
Blank
Blank
Blank Blank

how long does pegintron stay in the body?

I read that it stays in the body for 5-7 days and your level may be 0 before your next weekly injection. Does anyone know for sure?
Thanks,
Dave
Related Discussions
2 Comments Post a Comment
Blank
338734_tn?1377163768
I think it depends on some individual factors, particularly renal clearance of the drug. I found this information in the drug reference:

According to the manufacturer's tests, the drug reaches maximum serum levels between 15 and 44 hours after subcutaneous injection of a single dose. The mean elimination half-life is 22 to 60 hours (mean = 40 hours). So, I would expect that after 7 days (4.2 half-lifes) that the concentration would be about 5.5% (0.5^4.2) of the maximum levels.

From the published pharmokinetic studies on Pegintron:
-----------------------------------------------------------------------------------
Pharmacokinetics
Following a single subcutaneous dose of PegIntron, the mean absorption half-life (t ½ ka) was 4.6 hours. Maximal serum concentrations (Cmax) occur between 15 and 44 hours post dose, and are sustained for up to 48 to 72 hours. The Cmax and AUC measurements of PegIntron increase in a dose-related manner. After multiple dosing, there is an increase in bioavailability of PegIntron. Week 48mean trough concentrations (320 pg/mL; range: 0, 2960) are approximately 3-fold higher than Week 4 mean trough concentrations (94 pg/mL; range: 0, 416). The mean PegIntron elimination half-life is approximately 40 hours (range: 22-60 hours) in patients with HCV infection. The apparent clearance of PegIntron is estimated to be approximately 22mL/hr·kg. Renal elimination accounts for 30%of the clearance.

Pegylation of interferon alfa-2b produces a product (PegIntron) whose clearance is lower than that of nonpegylated interferon alfa-2b. When compared to INTRON A, PegIntron (1 mcg/kg) has approximately a 7-fold lower mean apparent clearance and a 5-fold greater mean half-life, permitting a reduced dosing frequency. At effective therapeutic doses, PegIntron has approximately 10-fold greater Cmax and 50-fold greater AUC than interferon alfa-2b.
Blank
338734_tn?1377163768
P.S. The concentrations of Pegintron at 7 days post injection (the trough) would be lower early in the TX period and higher later in the TX period.
Blank
Post a Comment
To
Blank
Weight Tracker
Weight Tracker
Start Tracking Now
Hepatitis C Community Resources
RSS Expert Activity
242532_tn?1269553979
Blank
Control Emotional Eating with this ...
Sep 04 by Roger Gould, M.D.Blank
242532_tn?1269553979
Blank
Emotional Eating Control: How to St...
Aug 28 by Roger Gould, M.D.Blank
233488_tn?1310696703
Blank
New Cannabis Article from NORTH Mag...
Jul 20 by John C Hagan III, MD, FACS, FAAOBlank
Top Hepatitis Answerers
163305_tn?1333672171
Blank
orphanedhawk
Rural Mural, CA
683231_tn?1408489117
Blank
flyinlynn
Auburn, WA
446474_tn?1404424777
Blank
HectorSF
CA
1815939_tn?1377995399
Blank
pooh55811
96938_tn?1189803458
Blank
FlGuy
South, FL
Avatar_f_tn
Blank
nan535
Brooklyn, NY