insulin resistance and interferon

Is insulin resistance a reason for failing to clear the virus after treatment and if it is , how can I treat the insulin resistance?
Can Interferon cause Insulin Resistance?  
13 years post treatment I feel worse than ever and I do not beleive it is solely the virus.

[merryBe]

yes, Insulin resistance means there ends up being too much sugr in yur blood and ergo too much uinsulin, and the insulin cancels out the efficacy of the Interferon causing less than optimal VL responses. People with high IR clear later, and SVR far less frequently.

"CoWriter" has also compiled a list along with commentary here:
http://www.medhelp.org/user_journals/index/568322?personal_page_id=450

[portann]

There are many reasons for failing to clear the virus. You have to keep in mind that when you treated thirteen years ago, treatment was in its infancy. Do you know at what week you cleared the virus during your tx and what treatment protocol you were on at that time? Regular interferon only?

Treatment, testing and protocols have changed a lot and for the better since then. I hope you're being followed by a hepatologist (liver specialist) and having regular biopsies. You should closely monitor your liver staging and consider further treatment, either now or when new therapies are approved in the not too distant future.

A qualified and experienced hepatologist will be able to properly assess all your risk factors and tailor a  treatment plan specifically based on you. If your doctor determines you have insulin resistance, which is a risk factor, he will advise you what to do about it and how significant a role it may play in your tx.

We are not medically qualified to tell you how to treat it.

We are not medically qualified to tell you how to treat it.








At what stage in your treatment thirteen years ago did the virus become undetectable in your blood?
To ascertain whether you have insulin resistance and to treat it, you have to see a qualified medical doctor.

[Lauma]

Insulin resistance is one reason why treatment may have failed for you. If you are considering retreating insulin resistance is one of the factors you should look at to  improve your success rate. Other things also have an influence.  If you were treating with mono therapy 13 years ago  you may have a better response with pegylated combination therapy.

[portann]

Unfortunately, what trumps everything in terms of treating successfully is genotype.

If you are the most common genotype in North America, Genotype 1, you barely had a fighting chance with the protocol probably available thirteen years ago. Were you on monotherapy?

Things have improved greatly for Genotype 1's and look like they're getting better still.

You do need to put yourself into the hands of a liver specialist. Thirteen years is a long time.

[puppiepaws]

Iam insulin resisitance and i treated for 48 weeks and then relapsed, but at least my liver got a rest.. Insulin resistance can make it harder to reach where u wanna be.. Iam 2 and 2 and hep c 1A.. I feel like it nothing else i have gave my good old liver a resting time.. Have a blessed day.. Sandy

[Ealonder]

Well I'm seeing a consultant next week , see what he has to say , thanks for the help everyone.
ISomebody asked about my treatment ? I completed 24 weeks mono therapy.

I hope to get some Insulin tests done , a HOMA test or fasting Glucose and Insulin. ALso a biopsy and a repeated PCR , then I'll know more.

[Ealonder]

At what stage in your treatment thirteen years ago did the virus become undetectable in your blood?

It didn't I failed to achieve an svr.