thank you dave,
medicmommy has a good point, i believe now that if i had double dosed on inf
the first week or two , i would be und already. did not have enough stomach to
do it on my first tx without hep doc support. hopefully i will never have to but
it is already noted should there be another one.
b
I hope it goes well and u get your und soon. Best of luck - Dave.
it's wonderful to hear that you are cured after what sounds like a very tough battle. It's pretty crazy what we have to put our bodies through only for a chance at svr, but of course what alternative do we really have.
I thought that riba and interferon took about a month to reach therapeutic levels and that's why they were doing 4 week lead-ins with the boceprevir trial I am currently part of. I guess if people become und after a couple of weeks it can happen much sooner.
Thank you for explaining and for sharing your experience-Dave
Hello!
I haven't visited this side much in the past year, so I don't recognize many names anymore...I became UND on tx 2 1/2 yrs ago, and SVR fro 18 months...At week #12, my HGB and HCT mostly leveled off at 8.5 and 26.5 with my Neutrophils hanging around 200...Dr didn't think rescue drugs were necessary even when things got a bit worse and I was experiencing chest pain and shortness of breath (man, if only I'd had the energy to roll some old lady for her oxygen bottle...) I look back now and realize I should have gone to the ER for care but I was afraid I'd be taken off of tx...At the time, I also had thyroiditis -caused by an uncommon side effect from the interferon that ticks off your thyroid and sends it into hyper mode. This sped up the hemolytic anemia. Without that, I'm sure my anemia would have been more stable.
Your question about pre-dosing with the Riba? Its because Riba is fat-soluble, and it takes several days to build up to theraputic effects in your body. When you finish txing, it takes several weeks (months in some) to purge it from your body. This is one of the reasons for SVR status at 6 months rather than sooner...I suspect this may also be why some people relapse within 1 year (because the riba remnants have been purged from their bodies)....Just my 2 cents-worth...MM
i know g4s that are non-responders or slow responders
would not do 24wks if i can help it , min. 36wks or 48.
i know two G4 for RVR;d and did 24 wks and got svr, so should be ok
they had higher VL than you too and did not predose or take supps
1. I am responding , good news
2. My enzymes are normal , my viral load is way down or maybe UND by now.
To me that`s all great news. One step at a time . If I am UND at 4 or 6 or 8 wk
as long as I am UND by wk12 is fine by me.
No , it is not fantastic and I saw that coming so that`s why I am doing all the extra effort
Geno 4 is not exactly considered easy and it shows.
Keep it real Bali while your waiting for 4 wk. Then maybe you can take a breath.
You started out with a low viral load and a very high dose of riba. You are responding ok, but a 1.39 log drop at 2 wks is not fantastic.
Trinity
yes i know , but you are not helping....
best thing is to see ur 4wk pcr , hopefully it will still be moving in the right direction
dont forget its a marathon not a sprint! long way to go yet
Sorry ,but your personal experience alone is not enough , I would need some more info like actual trial data....
That's what they tell me.
actually i had a 1.39 log drop from 2wks soc alone and i found a study where
2,4,8,12 pcrs were done, that said the 2wk pcr was 91% indicative of SVR
when there was a 1.39 log more drop. I don`t have wk 4 pcr yet .
I am actually pretty happy with my results so far , but it is all about SVR in the
end isn`t it ?
Bottom line, the marker is the 4 wk PCR. Shame no UND at 4 weeks but hopefully soon though eh?
quote
"again, show me some data that shows 0.41 log drop on riba alone during predose
precludes slow response"
personal experiance.......
calm down are you suffering a bit ?
again, show me some data that shows 0.41 log drop on riba alone during predose
precludes slow response.
you simply don`t know what you are talking about , fella !
well its less than half log thats all, i expect by now you are und having done 5 wks on riba plus 4 wks on combo, what was the load after your two wk PCR
"ehm yes slow responce in five weeks i would say fella, up the dose time i think"
and how exactly do you come to that conclusion ? fella !
you must have some riba predose data i am not aware of.
please share , if you will
I imagine a litigious society and obstacles involving cost as they apply to insurance companies are both very big players in these decisions? Plus, we do still practice evidence based medicine; this is probably the biggest impediment to experimental treatments like this.
“Do no harm”?
--Bill
How can they not try this with resistant people as a matter of course. I mean what is the point of being overly cautious when people are approaching or already have serious liver damage. it seems to me that it's all about liability. We should be allowed to make our own informed decisions as long as we understand the risks. Why the heck do we not have HPLC so we can get the right amount of these drugs rather then guess using side effects as a guide and putting people through repeated TX which itself carries risk. Thankfully some of you found doctors that are willing to help you do what it takes to get cured.
That makes sense ,
i am aware of the Lindahl study that`s why I am currently taking 2000-2400 mg.
doing great , minimal sx , just did shot#5. 4wk labs are being cooked.
cheers
b