new possibilities in treathment of hepatitis c

[bforro]

          We live in Romania - in Europe. My wife works in the public health, is head surgeon's mate, on  the City central hospital surgical department. In a January last year we begin  the treatment therapy for the hepatitis C  onto the treatment of virus  with a Rosch firm's products (interferon pegasys and ribavirin in dosage:  pegasys 1 ampoule 180 micrograms /weeks  and ribavirin 4 tablets of day). The HCV RNS test (methods  PCR) was  950,000 at the time of the beginning of the treatment ,after three months 3400 and after 6 months  was undetectable-negative. The treatment was continued  until  11 months, in the last months was suspended  because the hematologicaly results  decay . The HCV RNS test was repeated in the 13. month  (methods PCR) and showed a high value in scale  980,000 orders .The results of  TGG and TGO tests was  58 and 60 orders in scale.

      I'am scientific researcher in phisycs.The science that I do is not help me, I would like to get concrete information to  receive actual informations from you.. Is possible, exists that the result of the HCV RNS test  after 6 months was undetectable and after treatment to reach a value so high as the original.? Think we should repeat the analysis.

      If  repeat the analysis it and confirm  continued high value as the original versions of which way are followed?  I talked with colleagues across borders  about a continuation of the treatment with PEG-intron  (Schering-Plough)  whit combination ribavirin (Rebetol).

Please respect has told me about in a few words about investigations, about the possibilities for new drugs  in hepatitis c treatment, alternative treatments to date ,new drugs, etc.



With great respect,

[copyman]

I agree, great advice Jim

[Mary4now]

Oh,  thank you
your response was clear and logical and should be saved somewhere for reference.

[Mary4now]

What a great response Jim,

[jmjm530]

Yes, it's possibly. You had a two-log drop at week 12 but you were not Undetectible. Ideally you would have been undetectible at week 4 if you were genotype 2 or 3 and no later than week 12 if you were genotype 1. Genotype 1's who are still detectible at week 12 loften have to treat for 72 weeks for a reasonably good chance of SVR (cure).

I would not treat again until you identify the reason for failed treatment. Reasons could vary from non-compliance to under-dosing ribavirin, to negative pre-treatment predictor such as IR (insulin resistance), obesity, cirrhosis, etc. In your case, assuming you were a genotype 1, it seems you were not treated long enough but I'm only working from limited information.

Also, is it possible to get a liver biospy or perhaps you already have? If you do no have significant liver damage you reasonably have time to wait for the more efficient and newer drugs now in trial called PIs (protease inhibitors). Two such promising drugs are Telaprevir and Boceprevir.

We could probably be a bit more helpful if you shared more of your statistics such as genotype, age, height, weight, stage (assuming you had a biopsy), and if you have been tested for IR (insulin resistance) or have a history of diabetes. If you didn't have a biopsy have you had an ultrasound and did it show normal spleen size? Do you know your pre-treatment ALT, AST, INR and Platelet count?

You should understand that there are no doctors here. We're all HCV patients or former patients. We do have a doctor in our professional forum who takes questions for a fee of around 20 dollars, U.S.

All the best,

-- Jim