rashes/telaprevir

[working dog]

i'd like to know how what percent of the folks that treat with telaprevir get rashes so bad they have to stop treatments?? also how long into tx do the rashes usually start.....billy

[Clyde4360]

I am on  telaprevir 4 weeks so far no rash, I have dark hair but I'm I guess I'm fair skined I hope I don't get it later but it's great to have the name of a cream that works just in case. Thank God for this site. Good luck working dog with your treatment!!

[lapis]

Yes, the cream is called CeraVe, could only find it at the hospital phamacy but it's the one topical that was soothing and moisturizing. Hope it helps!

Lapis

[crossroadsec]

I made it thru a ruff ruff night. Trying to shake off a benedryl hangover n get ready for work. I was plum goofy last night. It was mind boggling. I think I have 5 more weeks of Telaprevir. Help me TBJ! Good luck . Lapis -can u tell me the barrier cream?
I've always had clear, good skin. I tan easily n go boating, cycling, outdoors a lot. Now I'm housebound cuz rash is worse in heat. Thanks for listening to my rant.. Hi ho! Hi ho! It's off to work... Karen

[kcing]

5 weeks in had to discontinue use, 43 yr male, fair skin, rash covering 70% of body, HORRIBLE!!!

[working dog]

thanks mike......i don't know if i have a tougher time learning the keyboard or understanding all that info on thoughs web sites...one thing for sure it's great to have you guys simplify it for folks like me....btw... i did bookmark the site to take a better look at it....anyway... looks like 1 in about 20 to 25 can't continue tx because of the rash being too severe.....billy

[lapis]

Mikesimon gave you the statistics with percentage for rash.  I can tell you my personal experience, and what I've heard from others.  It seems that people who have trouble with rashes anyway (fair skin) tend to get the worst rashes on Tela.  I've never had problems with skin rashes in the past.  While on the Tela for the first 8 wks of tx, I developed a rash which was dry, itchy, burning and sandpapery, which began at 6 or 7 wks.  It was mostly on trunk and arms and thighs.  My skin was painful to touch and the many skin creams I tried hardly made a difference, though I did finally find something, a barrier cream, that helped.  When the Tela was d/c'ed (I got placebo for 4 wks) the rash improved markedly.  I think the rash side effect is one of the reasons they were trying to reduce the time on Tela.  In my trial, people who did get it got it for 8 or 12 wks.  In my case, 8 wks worked!

[mikesimon]

Rash, pruritus, and anemia more frequent among telaprevir-treated patients vs control patients

    * Severe rash rare, but more frequent among telaprevir-treated patients vs control patients (3% to 5% vs 0%, respectively)
    * Rash maculopapular in appearance
    * Median time to rash appearance: 7-28 days

http://www.clinicaloptions.com/Hepatitis/Journal%20Options/Collections/2010%20JO%20Hepatitis%20Volume%204/Articles/McHutchison-NEJM-2010/Capsule.aspx