I was wondering whether anyone had received cautions from their physician about possible carcinogeneic effects of ribavirin. The Roche/Rebetol docs do note that it is mutagenenic and "should be considered a potential carcinogen" and recent research on its effectiveness against hcv indicates that at least one of the mechanisms is via mutagenesis ("Ribavirin's antiviral mechanism of action:lethal mutagenesis?", J. Mol. Med 80:86, 2002 on pubmed). As far as I can tell its use in HCV therapy is more common than any other use of the drug and is quite recent so there probably enough data yet (we're the test case!) but I was wondering. I'm about to ask my Dr. to up my dose to 1200mg (now at 1000 though I weigh 183lb).
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