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sovaldi/olysio

The past 9 weeks I treated with olysio and sovaldi. They stopped at 9 weeks. The test came back at week 8 still positive.Tx was stopped. Geno 1A, Past biopsies showed stage 1 mild fibrosis. In 2010 they didn't get a good sample but told me it was probably still stage 1, but not sure. Now after an ultrasound that's "suggestive" of cirrhosis I fear after failed tx the progression will bring me down even quicker.Anybody have any GOOD info that olysio/sovaldi speeds up the virus progression? Dr.says no. Have been positive for 50 years. Since 1999 I have lived a very healthy lifestyle. For most of the years I supplemented and took the herbs to keep my liver in as good of shape as I could until a "cure" came along. So much for that idea. I never did the interf/riba. The past couple years for some reason I stopped taking my supplements, (glutathione raising supplts etc) I used to be a member of a group that was alternative oriented, then I stopped that. I did the q80 variance test and it was positive, and so I went ahead with the tx. My question is: Is this new drug coming out only for those who weren't sensitive to the q80? Or is it supposed to take care of tough bugs like mine? Im hopeful I will be elegible for the new tx. Im 68 now. I am starting to experience symptoms, unpleasant symptoms. Good days/bad days. Sorry for rambling but I saw Bluemetals comment about disease progression after failed tx and it kinda spooked me.
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317787 tn?1473358451
Hello there!  Pooh has given you great advice, places to look.
I wanted to add that I don't believe the tx can make you worse.
I treated and relapsed in 2009, while my numbers did look bad at first my Hepatologist assured me that my body would normalize.
I went for a second opinion, he said the same thing.  My numbers did normalize and both doctors said I had given my liver a break from the HCV for the 35 weeks I was UND
Hang in there
Dee
Helpful - 0
1815939 tn?1377991799
Here is a link to several articles you can read about Sofosbuvir and Ledispavir. You can see it has very high cure rates.

http://hepatitiscnewdrugresearch.com/sofosbuvir-gs-7977ledipasvir-gs-5885.html
Helpful - 0
1815939 tn?1377991799
"Anybody have any GOOD info that olysio/sovaldi speeds up the virus progression? "
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No, there is no credible or documented evidence that olysio/sovaldi speeds up the virus progression.

There is no research data that was done by credible research scientists that states olysio/sovaldi speeds up the virus progression.

There is no documented research data or evidence that olysio/sovaldi speeds up the liver fibrosis progression.


"Is this new drug coming out only for those who weren't sensitive to the q80?"
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The new drugs coming out have nothing to do with the Q80 polymorphism. The Q80 polymorphism is resistant to protease inhibitors like Olysio.

The new all-oral combination of the  nucleotide polymerase inhibitor sofosbuvir and the NS5A inhibitor ledipasvir acts in a dufferent manner. Sofosbuvir is a nucleotide polymerase inhibitor and Ledispavir a NS5A inhibitor. They are NOT protease inhibitors so the Q80 polymorphism is not resistant to Sofosbuvir and Ledispavir..

"Or is it supposed to take care of tough bugs like mine?"
---------------------------------------------
Yes, it is supposed to cure bugs like yours.


Just hang in there. The new treatments will be out soon and you will be able to treat again.

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