Hepatitis C Community
statin drugs in place of riba
About This Community:

This forum is for questions about medical issues and research aspects of Hepatitis C such as, questions about being newly diagnosed, questions about current treatments, information and participation in discussions about research studies and clinical trials related to Hepatitis. If you would like to communicate with other people who have been touched by Hepatitis, please visit our new Hepatitis Social/Living with Hepatitis forum

Font Size:
A
A
A
Background:
Blank
Blank
Blank
Blank Blank

statin drugs in place of riba

I read that there has been a study done that suggests that statin drugs such as lescol may be as or more effective than riba for tx when combined with interferon. The study was done early this year.
Has anyone heard more on this. It would certainly lessen side effects
Related Discussions
5 Comments Post a Comment
Blank
Avatar_m_tn
I haven't heard anything about this.  But I have seen trial information on Tribavirin which is used like Ribavirin for influenza and appears to have less anemia side effects that it's Riba cousin.
Blank
137025_tn?1217768341
I read a study like that also.  But statins are killer-hard for your liver to take, so it's like one step forward, two steps back.  I think they may be tried for folks with little or no damage, but those of us with beat-up broke-down livers may never get to try statins.  The thought is very exciting tho, I'm trying to follow the idea myself.

Willow
Blank
Avatar_m_tn
If it is more effective than riba, why is it not being used. The side effects have to be less.
Blank
Avatar_n_tn
A news release regarding the study results of which you speak, can be found here:

http://www.medicalnewstoday.com/medicalnews.php?newsid=46747

The findings were published in the July 2006 issue of Hepatology, the official journal of the American Association for the Study of Liver Diseases (AASLD). Published by John Wiley & Sons, Inc.,

In part, the research indicates that:

"The researchers determined that the anti-HCV activities of statins were not related to cytotoxicity, meaning they did not kill the host cell. Additional experiments also suggested that, "the statins possess the ability to inhibit the replication of HCV RNA via a specific antiviral mechanism," the authors report."

"The researchers tested the theory that certain proteins are required for HCV RNA replication and that statins block the replication by inhibiting those proteins. In support of this theory, they found that the addition of both mevalonate and geranylgeraniol restored HCV RNA replication in the statin-treated cells."

"To evaluate statins as potential replacements for ribavirin in combination therapy, the researchers tested the anti-HCV activities of each one when combined with interferon. Each combination, except the one including pravastatin, had even stronger inhibitory effects on HCV RNA replication than when the statin was used alone. Again, fluvastatin plus interferon exhibited the strongest effect. "We clearly demonstrated that co-treatment of interferon and fluvastatin was an overwhelmingly effective treatment," the authors report. This combined therapy was more effective against HCV RNA replication than interferon alone and more effective than the standard combination therapy of interferon and ribavirin."

Anecdotally, my GI doc recommended I take fluvastatin (a.k.a. Lescol, by Abbott) in order to lower my slightly elevated lipid #'s and improve my liver tests.

A question for Willows, who said:

"I read a study like that also. But statins are killer-hard for your liver to take, so it's like one step forward, two steps back."

Willow, in light of the above, would you kindly elaborte your "statins are kller-hard" statement?
Blank
Avatar_n_tn
statins have effects on ast and alt levels and must be monitored regulary statins have cautions for use in pts with impared hepatic function calling for decreased dosage and increased monitoring of liver function google lescol prescribing info . saw a more complete text of the study in sep AASLD (i think) note the lescol concentration they used to obtain these results 6.7 umol/l also note their own statement that 40 mg daily dose of lescol steady state would yeild .6 umol/l that requires a 11x increase over medium blood levels my 1st thought rhabdomyolysis high ast alt levels these thoughts didnt seem to raise any red flags to the experts so must be only in my mind
Blank
Post a Comment
To
Blank
Weight Tracker
Weight Tracker
Start Tracking Now
Hepatitis C Community Resources
RSS Expert Activity
242532_tn?1269553979
Blank
Control Emotional Eating with this ...
Sep 04 by Roger Gould, M.D.Blank
242532_tn?1269553979
Blank
Emotional Eating Control: How to St...
Aug 28 by Roger Gould, M.D.Blank
233488_tn?1310696703
Blank
New Cannabis Article from NORTH Mag...
Jul 20 by John C Hagan III, MD, FACS, FAAOBlank
Top Hepatitis Answerers
96938_tn?1189803458
Blank
FlGuy
South, FL
1747881_tn?1358189534
Blank
hrsepwrguy
Greeley, CO
317787_tn?1373214989
Blank
Dee1956
DC
Avatar_f_tn
Blank
Livelife777
Avatar_f_tn
Blank
susan400
FL
163305_tn?1333672171
Blank
orphanedhawk
Rural Mural, CA