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1084115 tn?1385228589

svr rates with reduced riba

hello,

i read somewhere in this forum that reduced riba after 12 weeks does not have an impact on svr rates.
but i cant no more find this posts/topic.
iam still on 800 mg(copegus) (iam 50 kg)till my hgb is stable, and my doc maybe wants me to keep on this dose.
normally i had 1000 mg.
i was UND week 4+12 and wonder if this 200 mg less will have an effect on my svr chances.

thanks for some infos or links to this topic
6 Responses
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2135877 tn?1381861126
It is posts like this that make this forum so valuable to me.  I was just riba reduced an hour ago and was concerned.  Reading your post calmed me way down.  Thank you.
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Avatar universal
"SVR rates were 76% for patients who underwent RBV dose reductions and 72% for patients who did not reduce their dose of RBV."

So would that indicate optimum RBV level dosing could be determined by HGB count?
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2004810 tn?1365153611
Hi,
that was good news to me too, after reading can-do-man's answer cause I'm waiting for my 12 weeks results to hopefully reduce on the Riba (if still UND). I'm on 800 mg now but will hopefully reduce to 600 or something.
Hgb down at 8.5 with transfusions every second week...getting a bit tired of it. But hanging in :)

good luck to you!
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1084115 tn?1385228589
thanks for the infos.

@can-do-man,
iam working on my anxiety with my doc and its getting better,slowly.
thanks a lot

Helpful - 0
Avatar universal
Guy your going to stress yourself to death.... Good luck.

In clinical trials, anemia was managed with RBV dose adjustment only; use of erythropoietin was not allowed in the studies of telaprevir. The SVR rates remained high in patients undergoing RBV dose reductions for anemia in ILLUMINATE and ADVANCE[21]; indeed, SVR rates were 76% for patients who underwent RBV dose reductions and 72% for patients who did not reduce their dose of RBV. Therefore, these data strongly indicate that the management strategy for anemia should be to first reduce RBV. Although erythropoietin was not used in the registration trials, there may also be a role for its use in patients who develop symptomatic anemia during telaprevir-based therapy, primarily to avoid treatment discontinuation or interruption due to anemia.  

http://www.clinicaloptions.com/Hepatitis/Annual%20Updates/2011%20Annual%20Update/Modules/DAA%20Naive/Pages/Page%206.aspx
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Avatar universal
As long as you are taking the Riba, the dose reduction won't matter.
Helpful - 0
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