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svr rates with reduced riba
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svr rates with reduced riba

hello,

i read somewhere in this forum that reduced riba after 12 weeks does not have an impact on svr rates.
but i cant no more find this posts/topic.
iam still on 800 mg(copegus) (iam 50 kg)till my hgb is stable, and my doc maybe wants me to keep on this dose.
normally i had 1000 mg.
i was UND week 4+12 and wonder if this 200 mg less will have an effect on my svr chances.

thanks for some infos or links to this topic
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6 Comments Post a Comment
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Avatar_f_tn
As long as you are taking the Riba, the dose reduction won't matter.
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Avatar_m_tn
Guy your going to stress yourself to death.... Good luck.

In clinical trials, anemia was managed with RBV dose adjustment only; use of erythropoietin was not allowed in the studies of telaprevir. The SVR rates remained high in patients undergoing RBV dose reductions for anemia in ILLUMINATE and ADVANCE[21]; indeed, SVR rates were 76% for patients who underwent RBV dose reductions and 72% for patients who did not reduce their dose of RBV. Therefore, these data strongly indicate that the management strategy for anemia should be to first reduce RBV. Although erythropoietin was not used in the registration trials, there may also be a role for its use in patients who develop symptomatic anemia during telaprevir-based therapy, primarily to avoid treatment discontinuation or interruption due to anemia.  

http://www.clinicaloptions.com/Hepatitis/Annual%20Updates/2011%20Annual%20Update/Modules/DAA%20Naive/Pages/Page%206.aspx
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1084115_tn?1385232189
thanks for the infos.

@can-do-man,
iam working on my anxiety with my doc and its getting better,slowly.
thanks a lot

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2004810_tn?1365157211
Hi,
that was good news to me too, after reading can-do-man's answer cause I'm waiting for my 12 weeks results to hopefully reduce on the Riba (if still UND). I'm on 800 mg now but will hopefully reduce to 600 or something.
Hgb down at 8.5 with transfusions every second week...getting a bit tired of it. But hanging in :)

good luck to you!
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Avatar_m_tn
"SVR rates were 76% for patients who underwent RBV dose reductions and 72% for patients who did not reduce their dose of RBV."

So would that indicate optimum RBV level dosing could be determined by HGB count?
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2135877_tn?1381864726
It is posts like this that make this forum so valuable to me.  I was just riba reduced an hour ago and was concerned.  Reading your post calmed me way down.  Thank you.
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