teleprevir

[MedoZero]

Hi Ppl , How r every one ?? ok Lets go to my Q. what is teleprevir and is that a promissing cure ? and plz dont give me links to read as my English is bad lOL >> Just tell us ur opinion
< I hope that they Descover a cure >

Yours,
Hep.C Medo

[Willy50]

I forgot to add that the latest SVR rates that Vertex reported for naives in a European trial was over 80% for geno 1's.  They passed that on at their annual stockholders report.

Short of waiting for a trial w/o interferon you may be in for a wait.  Even trials have their own problems; not always the most ideal means of treating.

Good luck with the biopsy.  That will help point your course....

Willy

[mr.lucky66]

Thanks for the good info. Willy. Even though my liver is in good shape, I've had HVC for a long time. My GI didn't recomend Tx last year but will get a new Biopsy later this year and re evaluate. I am close to 60 and that seems to be when some folks with my same history get liver cancer, in their early 60's. Thanks

[Willy50]

No.  Teleprevir is used WITH current treatment.  Generally speaking it's 12 weeks triple dosing followed by 12 weeks current treatment (with IFN and RBV).

I think that they are working on the dosing adjustments based on viral response kinetics; fast responders might treat shorter periods of time and slower responders might extend treatment.  

There is currently no approved treatment without some variation on interferon and it could be 5 years before we see one approved...... just my guess.

best,
Willy

[mr.lucky66]

Teleprevir is the new non interfuron TX for HVC?

[Willy50]

Telaprevir is the same as VX-950.  It is in trial right now and results good but we will know much more in one month.  Last strong data was in December 2006.  Vertex announced that 88% of the trial participants had cleared the virus after about 12 weeks of treatment, but that this was a early (and NOT complete) trial result.  In one month we will have very good data.  Even with good results this drug may not be available for almost 2 years.  It's still in FDA trails.

best,
Willy

[mremeet]

I'm taking telaprevir (or did take it) and it worked really well at knocking down my virus very quickly. It did give me a bad rash, so it does cause bad side effects in some people (but not all). It's not clear if telaprevir will get approved for use in the general public (outside of a trial setting), but in my opinion based on what I know at this point, I would guess telaprevir will be approved. For most people with hep C, telaprevir should greatly contribute to the effectiveness of interferon and ribavirin treatment - which should translate into a significantly higher "cure" rate and/or a shorter course of treatment.