Aa
therapeutic vaccine decreases fibrosis - early trials
What follows is an extract from a press relese by Innogenetics
The full release can be found at
http://www.innogenetics.be/site/newspressrecent.asp?id=126
Seems like some good news to me - but don't get too excited as these things don't always work out
Innogenetics today announced the 3-year histology data of its ongoing phase 2a study in hepatitis C (HCV) patients, which started in early 2001. After 4 courses of HCV E1-based therapeutic vaccine injections given over a 3-year period in 23 patients, liver fibrosis on average showed significant improvement compared to baseline.
The key finding that has now emerged is a regression (improvement) of liver fibrosis averaging minus 0.43 points (95% confidence interval [-0.82, -0.05]) on the Ishak fibrosis scale. This result constitutes a significant decrease (p = 0.044) from baseline. No less than 87% (20/23) of the patients either improved (10/23) or remained stable (10/23) in their Ishak liver fibrosis score. This group of patients (mean age at entry 53 years, HCV genotype 1, with active liver disease) were, for the most part, non-responders to previous interferon-based therapy. Such patients would be expected to show a marked progression in liver fibrosis of about + 0.60 to about + 0.99 points on average...
The full release can be found at
http://www.innogenetics.be/site/newspressrecent.asp?id=126
Seems like some good news to me - but don't get too excited as these things don't always work out
Innogenetics today announced the 3-year histology data of its ongoing phase 2a study in hepatitis C (HCV) patients, which started in early 2001. After 4 courses of HCV E1-based therapeutic vaccine injections given over a 3-year period in 23 patients, liver fibrosis on average showed significant improvement compared to baseline.
The key finding that has now emerged is a regression (improvement) of liver fibrosis averaging minus 0.43 points (95% confidence interval [-0.82, -0.05]) on the Ishak fibrosis scale. This result constitutes a significant decrease (p = 0.044) from baseline. No less than 87% (20/23) of the patients either improved (10/23) or remained stable (10/23) in their Ishak liver fibrosis score. This group of patients (mean age at entry 53 years, HCV genotype 1, with active liver disease) were, for the most part, non-responders to previous interferon-based therapy. Such patients would be expected to show a marked progression in liver fibrosis of about + 0.60 to about + 0.99 points on average...
I noticed the WAS 1b thingy. I guess once 1b NOT ALWAYS 1b!
felicitazioni! felitations! felicidades! etc etc
felicitazioni! felitations! felicidades! etc etc
I AM SO THRILLED FOR YOU!!!!!!!!!!!!!!!!
OH HAPPY DAYS R HERE AGAIN!!!!!!!!!!!
U CAN NOW KICK BACK AND JUST ENJOY...
BE WELL ALWAYS,
LIZE :O)
OH HAPPY DAYS R HERE AGAIN!!!!!!!!!!!
U CAN NOW KICK BACK AND JUST ENJOY...
BE WELL ALWAYS,
LIZE :O)
Congratulations to the both of you!!
It is a happy day indeed. It gives hope to the rest of us on or contemplating tx.
It is a happy day indeed. It gives hope to the rest of us on or contemplating tx.
Happy Day for you! As a 1B, you have certainly given me encouragement to finish my next 38 weeks. I go for my 12 weeks PCR on April 9 and am anxiously awaiting getting the results already. But hearing that you made it through to the other side makes the wait bearable. I am so happy for you! Thanks for all your contributions to this Board. Celebrate Life!
Glad to hear from you and that your recovery is going reasonably well. Bummer about the Orange not making it to the final four this year...
Congratulations on your excellent news. I'm very pleased for you. Will you be serving your customers champagne at the salon today?
hey way to go!!! all your hard work paid off!!!! i think we finished around the same time and im also clear 6 mon. post tx. what great news!!! to be able to tell people you are in remission or cured even!!(?) hope you continue to thrive immensely.
That's really excellent news, looks like you kicked that ol' dragon's butt for good, really gives the rest of us 1b-ers hope!!!!!!
Galen-
<B>WHOOOOPPPPIEEEE!!</B>
That's the best news I've heard all week! Another 1-B bites the dust!
Is-this-real,
Really happy to hear that you've cleared at 8 weeks. Keep up the good work!
Best to all you hep warriors out there.
newb
<B>WHOOOOPPPPIEEEE!!</B>
That's the best news I've heard all week! Another 1-B bites the dust!
Is-this-real,
Really happy to hear that you've cleared at 8 weeks. Keep up the good work!
Best to all you hep warriors out there.
newb
Congratulations girl. You have done it. That ole virus never had a chance. I am happy for you sooooo much, and you give us all hope.
By the way, I also have some news. As you remember, I am a 1a with an initial very high viral load. I started my Pegasys combo treatment on 1/16/04. Last week, I went in to my doctor for 8 week tests on 3/15/04.
After 8 weeks of the drugs, I too am undetectable. I still have 38 shots left, but this should be a breeze now.
Recent studies I have read suggest that if a geno 1 treats for 32 to 36 weeks post clearance, their SVR percentage shoudl be 80 - 90%. So, my chances are much improved now!
By the way, I also have some news. As you remember, I am a 1a with an initial very high viral load. I started my Pegasys combo treatment on 1/16/04. Last week, I went in to my doctor for 8 week tests on 3/15/04.
After 8 weeks of the drugs, I too am undetectable. I still have 38 shots left, but this should be a breeze now.
Recent studies I have read suggest that if a geno 1 treats for 32 to 36 weeks post clearance, their SVR percentage shoudl be 80 - 90%. So, my chances are much improved now!
Galan....this is great news! Feel like a new women, hum. I'm sure you've gone back to work....business must be booming since you have more energy now, and are able to get out there and advertise a little more, hum.
But tell me this Indiana and Galan......is alcohol out of the question forever for you guys?
I'm doing okay, don't have any aches or pains; I just feel a little stiffness in my liver area. Doc wants me to take an xray which isn't scheduled until 4/19. 3 Months post I was still clear, but time will only tell. Hi, MAJ Neni. Val.
But tell me this Indiana and Galan......is alcohol out of the question forever for you guys?
I'm doing okay, don't have any aches or pains; I just feel a little stiffness in my liver area. Doc wants me to take an xray which isn't scheduled until 4/19. 3 Months post I was still clear, but time will only tell. Hi, MAJ Neni. Val.
:) I'm so pleased to hear your results. I have appreciated all your support that you have given me since i first posted here last summer. As you might recall, I am also a 1 b
..........Deb
..........Deb
Great news and good luck with the rest of your "LONG LIFE"- you deserve it- you helped out alot of people tremendously on this forum when they were in real need of advice and a good friend.Can you really believe it's over- wasn't that a hell of a journey. Well at least we can say one thing for sure- we are certainly "Experts" on HCV now. See Ya Around -- Harley Dude
That's awesome news! I am so glad you posted. I was wondering how you were doing. I can't seem to get my strength back. I slept for three days already this week and seem to need between 10 and 15 hours of sleep a day. My doctor said I should be over all tx symptoms by now (4 months post tx) so I am looking for a new doctor.
Congratulations!
Barb
Congratulations!
Barb
Oh, Galen, that's just the best news! I'm so happy for you. It's good to hear you're feeling great, too!
ambush :)
ambush :)
Mikey: Thanks for the encouraging information. It's great to see the research moving forward on this terrible virus.
Galen: I'm very happy for you. Since I'm also a 1b, the success of your tx is a big encouragement. I know you lost your special kitty recently. That is a sadness I also share since we lost our cat, Keetz. She was our first family cat and we'll miss her. Pets have a special way of helping us when things get tough, don't they. My little eskie dog was there with me when I was in severe pain for months. I keep telling her she's a blessing from God and I mean it.
Wasn't going to log on tonight, but I'm glad I did. God Bless, Dave
Galen: I'm very happy for you. Since I'm also a 1b, the success of your tx is a big encouragement. I know you lost your special kitty recently. That is a sadness I also share since we lost our cat, Keetz. She was our first family cat and we'll miss her. Pets have a special way of helping us when things get tough, don't they. My little eskie dog was there with me when I was in severe pain for months. I keep telling her she's a blessing from God and I mean it.
Wasn't going to log on tonight, but I'm glad I did. God Bless, Dave
Minttwist.....it seems that every time we try to talk about alcohol and hcv, Whatever the reason, it ends up in a fight. So if you really want my thoughts on this, send me an e-mail at ***@**** I will respond. I really don't want to ruin this splendid thread.
Itr.....There is a lot of current data that says that you now have an "excellent" chance of killing The Dragon. You and I have looked at this for you for a LONG time. I am Sooooo happy that this is working so well for you now. It won't be easy.....but it WILL be worth it. I will be here ...and there... for you. You CAN do this!
Best of luck as you go through the gauntlet. We are always here for you........
Itr.....There is a lot of current data that says that you now have an "excellent" chance of killing The Dragon. You and I have looked at this for you for a LONG time. I am Sooooo happy that this is working so well for you now. It won't be easy.....but it WILL be worth it. I will be here ...and there... for you. You CAN do this!
Best of luck as you go through the gauntlet. We are always here for you........
You go, Galen. Terrific news. We really ought to get a bigger party going for some of us dragonslayers this year. Any badgers in FL?
Val, nice to catch your note. I hope you feel better soon, and that life throws fewer spit-balls at you.
I'm feeling pretty good now, 2 months after tx. My skin has recovered (exc. for seasonal trouble; Elidel rules); my hair is still thin, and it seems to be a dust-magnet. Blood counts are improving slower than we thought, so I'm using up my leftover Neupogen with the Friday Night brigade. I'm also having some joint-stuff; want to follow up on my low + RA factor.
There's an RA study going on here, I'll see if I qualify. My brain is working, except for the memory; and I have good energy until I suddenly hit empty. My appetite is sooooo good.
I finished Undetectable on Jan.23, after my 48 weeks. (1b/stage 1/grade 2, high VL to start.) I'm still negotiating for the 3-month PCR...
This whole tx business is so mental, and waiting - at every stage - is... well... you know.
I've been having computer problems, but I usually still read a couple of times a week. Greetings, folks. I hope we keep it nice here.
Majneni
Val, nice to catch your note. I hope you feel better soon, and that life throws fewer spit-balls at you.
I'm feeling pretty good now, 2 months after tx. My skin has recovered (exc. for seasonal trouble; Elidel rules); my hair is still thin, and it seems to be a dust-magnet. Blood counts are improving slower than we thought, so I'm using up my leftover Neupogen with the Friday Night brigade. I'm also having some joint-stuff; want to follow up on my low + RA factor.
There's an RA study going on here, I'll see if I qualify. My brain is working, except for the memory; and I have good energy until I suddenly hit empty. My appetite is sooooo good.
I finished Undetectable on Jan.23, after my 48 weeks. (1b/stage 1/grade 2, high VL to start.) I'm still negotiating for the 3-month PCR...
This whole tx business is so mental, and waiting - at every stage - is... well... you know.
I've been having computer problems, but I usually still read a couple of times a week. Greetings, folks. I hope we keep it nice here.
Majneni
Congrats! You have helped me and so many others here and as a 1b hope to follow in your footsteps.
dh bill
dh bill
Wonderful news, real happy for you. I'm a 1b guy with 5 shots left and I hope to be following in your footsteps!
galen: great news - congratulations on becoming an official SVR! I wish you all the best and many thanks for everything you've contributed to this forum.
mickeymike: thanks for the interesting link. Looks like taking the drug amounts to taking injections of E1, one of the virus' two envelope proteins. I wonder what's known about sides at this stage? Taking something that boosts specific immunity to HCV would seem to have lighter overall impact on the body than general-purpose immune stimulators like ifn/riba.
mickeymike: thanks for the interesting link. Looks like taking the drug amounts to taking injections of E1, one of the virus' two envelope proteins. I wonder what's known about sides at this stage? Taking something that boosts specific immunity to HCV would seem to have lighter overall impact on the body than general-purpose immune stimulators like ifn/riba.
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