treatment for failure to respond on interferon therapy for chronic hepatitis c

[momdadmev3]

my mom is suffering from chronic hepatitis c and she was diagnosed by routine screening and there were no symptoms at that time, her PCR quantitative was done and the conts were 5,856,721 copies/ml
she was started with simple interferon and ribavirin therapy for 6 months after which her PCR was repeated which came out as 68,000 copies/ml.
after which she was adviced to continue treatment for further six months
her counts turned out to be 274,200 copies/ml after six months.
now she was offered pegylated interferon with ribavirin, after three months her counts by PCR[ Amplicor] technique came out as 8.31 * 10 *2
GENOTYPE 1b
Now at this stage her t/m was stopped due to thrombocytopenia ( platelet counts 117,000)
can u please tell me what t/m should be offered to her

[momdadmev3]

Thanks for giving ur opinion.
Actually she is being treated in Pakistan.
she is treated by GI  doctor and let me tell u her genotype is 1b.

[Bill1954]

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[Bill1954]

Unfortunately, if the numbers you mention above are correct, your mom shouldn’t have been advised to continue interferon-ribavirin treatment at the initial six-month treatment juncture. Her viral load of 68,000 copies at six months indicates she was a non-responder to the treatment, and had an extremely low chance of succeeding.

The second treatment you mention thrombocytopenia cited at 117,000? Generally, doctors that are current with HCV treatment will allow their patients to continue with treatment until platelets reach ~40-50,000, when they are dose reduced, not pulled from treatment entirely.

Is your mom under the treatment of a GI doc or a hepatologist? Is she treating in Europe or north America?

Bill