wbc / anc fluctuations

I was diagnosed with hepatitis c with a 1B genotype. Taken 21 injections of Pegasys 180 mcg till date. i am having very wide fluctuations in WBC and ANC. The range is between 6500 and 1400 for WBC and 4700 and 260 for ANC. Doctors unable to give any explanation for such wide variations on a dose to dose basis. Till date, I have also taken 5 doses of Filgrastim - the WBC Stimulator.

Can you pleae advice possible reasons for such wide fluctuations.

Thanks and kind regards,

Raghu

[newleaf09]

The PEG can stay pretty steady for 7 days, but depending on when your bloodwork is taken in relation to shot, wbc may start to come up before next shot, when it is beat back down.  Interferon is an amazing drug with lots of far-reaching effects.  It may be unpredictable with wbc, but as long as levels stay within safe ranges, you ought to be okay, in my opinion.