what is the ideal dosage of pegintron

[spectda]

I read that the fda approved dosage is 1.5 mcg per kg. Is that the ideal dosage or is it higher? I figure at my weight of 85 kg I was getting 1.76 mcg per kg. Now I am being dose reduced to a little over 1.05 mcg per kg (the guideline for adverse event neutropenia).  There's really nothing I can do, just obsessing about the reduction. I am going to have two injections at that level before I see the doc again and hopefully go back to full dose. These will be week 8 and week 9 injections.
I know it's not good especially this early. but the one thing in my favor is I am on boceprevir and possibly it will pick up the slack.
Oh well!

[jusjames]

pegintron is 150 or 120 , then you have dialing options which alter it further
2a is stnd dose & 180

[spectda]

The dose for pegasys is 180, pegintron 150 or 1.5 per kg. I've read some studies that show much higher svr rates with pegasys and less adverse events. I also read some studies that show very similar svr rates between the two, but the pegintron generally has more sides. I think Bill was successful with pegintron on his second time, but perhaps it's the high dosing of both that and riba and the crazy length of time he endured.

[spectda]

Thanks bill, something I read did show a drop in svr, but not an enormous one from 150 to 100 when necessary for an adverse event. I hate to go through all this to jeopardize my chances, very frustrating. I still am astounded that you treated the last time for 2 years, from what I remember you were basically in treatment for almost 3.5 years between the two tx. No adverse reactions, you are a freakin rock!

[Bill1954]

Dave, I treated rather aggressively I believe; my formally assigned Pegintron dosage was 150 µg/week or roughly 1.5 µg/kg/week. However, with my doctor’s tacit approval I increased that by injecting the entire vial as I drew it up; perhaps as much as ~204 µg/week.

I imagine pcds is using Pegasys if her dosage is 180 µg/week? I think Pegasys is a ‘one size fits all’ injection.

In the past, there were trials that involved ‘induction’ method, where high initial IFN dosing is used; up to 360 µg/week for the first 12 weeks, then adjusting down for the duration. I don’t believe much came of this, honestly; I haven’t heard of any more of these trials for a while now.

--Bill

[pcds]

My injection is 180, that's the marker I set my plugger to and is the standard dose for all.  It's the ribaviron that is weight adjusted.  I'm on the 600/400 per day dosage for a wt of 125lbs.  When my WBC tanked, one option was dose reduction, the other neupogin, I went for the neupogin no question.  With genotype 1, I need all the dosage I can get.  My WBC now is acceptable.  Low, but not a great threat.  It goes as low as 2.7 right before my next neupogin shot.  Diff with you is you are on boceprevir, I wish I had that back up.