GS-7977 and Ribavirin Clinical Trial

[HectorSF]

I found out today I AM UNDETECTABLE after 2 weeks of treatment with GS-7977 and Ribavirin.

Not bad for a previous null-responder to peg-INF and Ribavirin where after 12 weeks of treatment my viral load never went below 360,000.

"An Open-Label Study to Explore the Clinical Efficacy of GS 7977 With Ribavirin Administered Pre-Transplant in Preventing Hepatitis C Virus (HCV) Recurrence Post-Transplant"  ClinicalTrials.gov Identifier: NCT01559844

During screening my viral load was 1,200,000
On day 1                                         692,000
1 week                                                   581
2 week                                                   <25

COBAS TaqMan HCV Test
week 1 dropped 3.06 logs
week 2 dropped 4.44 logs

Cheers!
Happy
Hector

[revenrick]

i really had no  side effects with gs7977,normal side effects with riba ,like rash and itching,having took interferon three different  times with riba ,48 weeks each time ,over a ten year period,only to relapse each time around the six months checkup.......,the gs7977 was an open label trial,took two  200 mg each day, 400 mg total a day with riba,1200mg a little dizzy at times,but nothing like what i went thru with the  interferon,the only negative thing of gs7977 was the taste ,taste like sulfur,ill take that over interferon any day

[MeWithC]

Glad it worked for you Hector....maybe my turn will come soon.

[gerard11]

How was your treatment on the GS-7977 / RIBA ?  Side effects? If you could talk about the experience I am sure many members would appreciate it. I know I would be one. Thank you...and good luck on your upcoming transplant. I

[revenrick]

congrats hector, i my self just finished 24 weeks of gs7977 and riba,and awaiting tx ,im a type3 null responder 3 times ,over last 10 years..my viral load started at 300.000 by week 3 it was >25 undetectable ,i just moved up to #2 on tx list ,have had 3 calls for backup transplant,over last two weeks,my meld score is 25 should go to 28 next week,looks like ill have a rebirthday with a new year .... from here in texas   good luck  hectorsf     !!!!!!!!!

[LookingForward12]

I may be late to the party, but heartfelt congrats are here for you now!

You are, undoubtedly, one of the most brave and stickwithit people on this forum. When you are ready, let me know, I'll send you a bushel of onions for that new liver!

Cheers!

[GINGERPAL]

Hector....This is wonderful news.  I wish you all the best !!  You deserve it.  gingerpal