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2059648 tn?1439766665

Hepatitis C - Thyroid

Does hepatitis C cause thyroid problems?  
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1815939 tn?1377991799
Thyroid disease is listed in this overview of extrahepatic manifestations of Hepatitis C:

http://www.hcvadvocate.org/hepatitis/factsheets_pdf/Extrahepatic.pdf

This is also a good article:

http://jid.oxfordjournals.org/content/early/2012/07/13/infdis.jis385.full

And in this article here is what it says about Hep C and Thyroid:

2.3. Autoimmune Thyroid DiseaseThyroid disorders are common in patients with chronic HCV infection. Approximately 10–25% of patients with persistent HCV infection have thyroid autoantibodies, including thyroid microsome autoantibodies (TMAs), thyroglobulin autoantibodies (TGAs), and antibodies to thyroid peroxidase autoantibodies (anti-TPO), regardless of the liver involvement severity [90–92]. TMAs are frequently useful to detect latent autoimmune thyroiditis in patients with CH-C prior to antiviral treatment [91]. The presence of TMAs also may predict thyroid dysfunction including hyperthyroidism and hypothyroidism [93]. Therefore, the detection of these thyroid autoantibodies is considered useful for the clinical diagnosis of concurrent autoimmune thyroid diseases in patients with HCV infection. However, HCV-associated thyroid disorders cannot be distinguished from primary thyroid disorder by the existence of these thyroid autoantibodies. The possible role of HCV in the development of thyroid disorders has not been fully understood.HCV-related thyroid disorders include Graves’ disease and Hashimoto’s thyroiditis induced by interferon (IFN) treatment [94, 95]. The discovery of anti-TPO at base-line may be regarded as a predictive factor for IFN-induced thyroid autoimmunity in patients with CH-C. A strong correlation between thyroid disorders and the presence of anti-LKM1 at base-line in patients with chronic hepatitis C was also observed [96, 97]. HCV poly protein, CYP2D6 and thyroperoxidase are likely to share epitopes encoding homologous amino acid sequences [97]. Therefore, seropositivity for anti-LKM1 is a susceptibity factor for IFN-induced autoimmune thyroid disorders in patients with HCV-related CLD.

http://www.hindawi.com/journals/cdi/2012/871401/

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Avatar universal
https://www.ncbi.nlm.nih.gov/pubmed/15210382

I liked this study, because they used over 600 people, but I still need practice, in noting the sources, etc
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Avatar universal
  Yeah, I used "metasearch" for a search engine also, and various articles came up on this topic, and I am also  planing on registering for Medscape, and then book-marking and filing this info, inspired by my Guru; Ms Pooh (I can be piglet, lol)
   Ya know...my little Sis had Thyroid Cancer, (it was removed) and I noticed her cousin also had thyroid problems, and it is thought to be genetic, thyroid problems, that it.  It also makes me want to suggest to my Sis, to get tested for Hep C...although she only snorted and smoked coke, "intra-nasal transmission" is listed as a risk. But years have gone by, and I am predicting she will react with total denial~
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2059648 tn?1439766665
The hepatitis.va.gov site state that hepatitis C can cause thyroid problem.
I was surprised by this statement.  
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